代表的文献

 
  1. 1.Kitamura, K., Tokunaga, M., Iwane A. H. & Yanagida, T. : A single myosin head moves along an actin filament with regular steps of 5.3 nanometres. Nature 397: 129-134 (1999).

  2. 2.Kitamura, K., Tokunaga, M., Esaki, S., Iwane, A. H. & Yanagida, T. : Mechanism of muscle contraction based on stochastic properties of single actomyosin motors observed in vitro. BIOPHYSICS 1: 1-21 (2005).

  3. 3.Kitamura, K., Judkewitz, B., Kano, M., Denk, W. & Hausser, M.: Targeted patch-clamp recordings and single-cell electroporation of unlabeled neurons in vivo. Nat. Methods 5: 61-67 (2008).

  4. 4.Kitamura K & Häusser M: Dendritic Calcium Signaling Triggered by Spontaneous and Sensory-Evoked Climbing Fiber Input to Cerebellar Purkinje Cells In Vivo. J. Neurosci. 31: 10847-10858 (2011).

  5. 5.Takahashi N, Kitamura K, Matsuo N, Mayford M, Kano M, Matsuki N & Ikegaya Y: Locally synchronized synaptic inputs. Science 335: 353-356 (2012).

  6. 6.Kawamura, Y., Nakayama, H., Hashimoto, K., Sakimura, K., Kitamura, K. & Kano, M.: Spike timing-dependent selective strengthening of single climbing fiber inputs to Purkinje cells during cerebellar development. Nature Commun. 4: 2732 (2013).

  7. 7.Tsutsumi, S., Yamazaki, M., Miyazaki, T., Watanabe, M., Sakimura, K., Kano, M., Kitamura, K.: Structure-function relationships between aldolase C/zebrin II expression and complex spike synchrony in the cerebellum. J. Neurosci., 35, 843-852 (2015).

  8. 8.Inoue M, Takeuchi A, Manita S, Horigane S-i, Sakamoto M, Kawakami R, Yamaguchi K, Otomo K, Yokoyama H, Kim R, Yokoyama T, Takemoto-Kimura S, Abe M, Okamura M, Kondo Y, Quirin S, Ramakrishnan C, Imamura T, Sakimura K, Nemoto T, Kano M, Fujii H, Deisseroth K, Kitamura K, Bito H.: Rational engineering of XCaMPs, a multicolor GECI suite for in vivo imaging of complex brain circuit dynamics. Cell 177: 1346-1360 (2019).

  9. 9.Tsutsumi S, Hidaka N, Isomura Y, Matsuzaki M, Sakimura K, Kano M, Kitamura K. Modular organization of cerebellar climbing fiber inputs during goal-directed behavior. eLife 8:e47021 (2019).

Full Publications (since 1997)

<2019>

Tsutsumi S, Hidaka N, Isomura Y, Matsuzaki M, Sakimura K, Kano M, Kitamura K. Modular organization of cerebellar climbing fiber inputs during goal-directed behavior. eLife 8:e47021 (2019). doi: 10.7554/eLife.47021.


Nakao H, Kishimoto Y, Hashimoto K, Kitamura K, Yamasaki M, Nakao K, Watanabe M, Kano M, Kirino Y, Aiba A. mGluR1 in cerebellar Purkinje cells is essential for the formation but not expression of associative eyeblink memory. Sci Rep. 9(1):7353 (2019). doi: 10.1038/s41598-019-43744-z.


Inoue M, Takeuchi A, Manita S, Horigane S-i, Sakamoto M, Kawakami R, Yamaguchi K, Otomo K, Yokoyama H, Kim R, Yokoyama T, Takemoto-Kimura S, Abe M, Okamura M, Kondo Y, Quirin S, Ramakrishnan C, Imamura T, Sakimura K, Nemoto T, Kano M, Fujii H, Deisseroth K, Kitamura K, Bito H. Rational engineering of XCaMPs, a multicolor GECI suite for in vivo imaging of complex brain circuit dynamics. Cell 177: 1346-1360 (2019). doi: 10.1016/j.cell.2019.04.007.



<2018>

Mizuno H, Ikezoe K, Nakazawa S, Sato T, Kitamura K, Iwasato T.  Patchwork-Type Spontaneous Activity in Neonatal Barrel Cortex Layer 4 Transmitted via Thalamocortical Projections. Cell Rep. 22, 123-135. doi: 10.1016/j.celrep.2017.12.012.



<2017>

Good J-M, Mahoney M, Miyazaki M, Tanaka KF, Sakimura K, Watanabe M, Kitamura K, Kano M. Maturation of Cerebellar Purkinje Cell Population Activity during Postnatal Refinement of Climbing Fiber Network. Cell Rep. 21, 2066-2073 (2017). doi.org/10.1016/j.celrep.2017.10.101


Nakai N, Nagano M, Saitow F, Watanabe Y, Kawamura Y, Kawamoto A, Tamada K, Mizuma H, Onoe H, Watanabe Y, Monai H, Hirase H, Nakatani J, Inagaki H, Kawada T, Miyazaki T, Watanabe M, Sato Y, Okabe S, Kitamura K, Kano M, Hashimoto K, Suzuki H, Takumi T.  Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice.  Sci Adv. 3:e1603001 (2017). doi: 10.1126/sciadv.1603001.


Manita, S., Miyakawa, H., Kitamura, K., Murayama, M.  Dendritic Spikes in Sensory Perception. Front. Cell Neurosci. 11:29 (2017). doi: 10.3389/fncel.2017.00029



<2015>


Tsutsumi, S., Yamazaki, M., Miyazaki, T., Watanabe, M., Sakimura, K., †Kano, M. & †Kitamura, K.: Structure-function relationships between aldolase C/zebrin II expression and complex spike synchrony in the cerebellum. J. Neurosci., 35, 843-852 (2015). doi: 10.1523/JNEUROSCI.2170-14.2015


Inoue, M., Takeuchi, A., Horigane, S.I., Ohkura, M., Gengyo-Ando, K., Fujii, H., Kamijo, S., Takemoto-Kimura, S., Kano, M., †Nakai, J., †Kitamura, K. & †Bito, H.: Rational design of a high-affinity, fast, red calcium indicator R-CaMP2. Nat. Methods 12, 64-70 (2015). doi: 10.1038/nmeth.3185.



<2014>

Masamizu, Y., Tanaka, Y.R., Tanaka, Y.H., Hira, R., Ohkubo, F., Kitamura, K., Isomura, Y., Okada, T. & Matsuzaki, M.: Two distinct layer-specific dynamics of cortical ensembles during learning of a motor task. Nat. Neurosci., 17, 987-994 (2014). doi: 10.1038/nn.3739


Tada, M., Takeuchi, A., Hashizume, M., Kitamura, K. & Kano, M.: A highly sensitive fluorescent indicator dye for calcium imaging of neural activity in vitro and in vivo. Eur. J. Neurosci., 39: 1720 - 1728 (2014).


Wang, J., Qin, L., Chimoto, S., Tazunoki, S. and Sato, Y.: Response characteristics of primary auditory cortex neurons underlying perceptual asymmetry of ramped and damped sounds. Neuroscience, 256, 309-321, 2014



<2013>

Kawamura, Y., Nakayama, H., Hashimoto, K., Sakimura, K., Kitamura, K. & Kano, M.: Spike timing-dependent selective strengthening of single climbing fiber inputs to Purkinje cells during cerebellar development. Nature Commun. 4: 2732 (2013).


Ikezoe, K., Mori, Y., Kitamura, K., Tamura, H. & Fujita, I.: Relationship between the local structure of orientation map and the strength of orientation tuning of neurons in monkey V1: a 2-photon calcium imaging study. J. Neurosci., 33, 16818-16827 (2013).


Kitamura, K. & Kano, M.: Dendritic calcium signaling in cerebellar Purkinje cell. Neural Networks 47: 11-17 (2013).


Hashizume, M., Miyazaki, T., Sakimura, K., Watanabe, M., Kitamura, K. & Kano, M.: Disruption of cerebellar microzonal organization in GluD2 (GluRδ2) knockout mouse. Front. Neural Circuits 7: 130 (2013).


Kawashima T, Kitamura K, Suzuki K, Nonaka M, Kamijo S, Takemoto-Kimura S, Kano M, Okuno H, Ohki K, Bito H: Functional labeling of neurons and their projections using a synthetic activity-dependent promoter E-SARE. Nat. Meth. 10: 889-895 (2013).


Fujii H, Inoue M, Okuno H, Sano Y, Takemoto-Kimura S, Kitamura K, Kano M & Bito H: Nonlinear decoding and asymmetric representation of neuronal input information by CaMKIIα and calcineurin. Cell Rep. 3: 978-987 (2013).


Hira R, Ohkubo F, Ozawa K, Isomura Y, Kitamura K, Kano M, Kasai H & Matsuzaki M: Spatiotemporal dynamics of functional clusters of neurons in the mouse motor cortex during a voluntary movement. J. Neurosci. 33: 1377-1390 (2013).


Kano M, Nakayama H, Hashimoto K, Kitamura K, Sakimura K, Watanabe M:  Calcium-dependent regulation of climbing fiber synapse elimination during postnatal cerebellar development. J. Physiol. (Lond)  591, 3151-3158 (2013).



<2012>

Kimura, R., Saiki, A., Fujiwara-Tsukamoto, Y., Ohkubo, F., Kitamura, K., Matsuzaki, M., Sakai, Y. & Isomura, Y.: Reinforcing operandum: rapid and reliable learning of skilled forelimb movements by head-fixed rodents. J. Neurophysiol., 108, 1781-1792 (2012).


Nakayama H, Miyazaki T, Kitamura K, Hashimoto K, Yanagawa Y, Obata K, Sakimura K, Watanabe M & Kano M: GABAergic inhibition regulates developmental synapse elimination in the cerebellum. Neuron 74: 384-396 (2012).


Takahashi, N., Kitamura, K., Matsuo, N., Mayford, M., Kano, M., Matsuki, N. & Ikegaya, Y.: Locally synchronized synaptic inputs. Science 335, 353-356 (2012).


Chimoto, S., Wang, J., Liu, Y., Qin, L., Nakamoto, K., and Sato, Y.: Stimulus parameters effective to evoke detection behaviors in the primary auditory cortex. Proc. Auditory Res. Meeting, the Acoustical Society of Japan, 42, 633-635, 2012


Wang, J., Liu, Y., Qin, L., Chimoto, S., Nakamoto, K., and Sato, Y.: Chronic microstimulation of cat auditory cortex effective to evoke detection behaviors. Neuroscience, 206: 81-88, 2012




<2011>

Kitamura K & Häusser M: Dendritic Calcium Signaling Triggered by Spontaneous and Sensory-Evoked Climbing Fiber Input to Cerebellar Purkinje Cells In Vivo. J. Neurosci. 31: 10847-10858 (2011).


Hashimoto K, Tsujita M, Miyazaki T, Kitamura K, Yamazaki M, Shin H-S, Watanabe M, Sakimura K, Kano M: Postsynaptic P/Q-type Ca2+ channel in Purkinje cell mediates synaptic competition and elimination in developing cerebellum. Proc Natl Acad Sci USA  108: 9987-9992, (2011).


Noguchi J, Nagaoka A, Watanabe S, Ellis-Davies GC, Kitamura K, Kano M, Matsuzaki M, Kasai H: In vivo two-photon uncaging of glutamate revealing the structure-function relationships of dendritic spines in the neocortex of adult mice.  J. Physiol. 589: 2447-2457 (2011).



<2009>

Hashimoto, K., Ichikawa, R., Kitamura, K., Watanabe, M. & Kano, M.: Translocation of a "winner" climbing fiber to the Purkinje cell dendrite and subsequent elimination of "losers" from the soma in developing cerebellum. Neuron  63: 106-118, (2009).


Schultz, S. R., Kitamura, K., Post-Uiterweer, A., Krupic, J. & Häusser, M.: Spatial pattern coding of sensory information by climbing-fiber evoked calcium signals in networks of neighboring cerebellar Purkinje cell. J. Neurosci., 29, 8005-8015 (2009).


Judkewitz, B., Rizzi, M., Kitamura, K. & Häusser, M.: Targeted in vivo single-cell electroporation. Nat. Protoc. 4: 862 - 869 (2009).


Sakai, M., Chimoto, S., Qin, L., Wang, J., and Sato, Y.: Differential representation of spectral and temporal information by primary auditory cortex neurons in awake cats: relevance to auditory scene analysis. Brain Research, 1265:80-92, 2009


Sakai, M., Chimoto, S., Qin, L., Wang, J., and Sato, Y.: Neural mechanisms of interstimulus interval-dependent responses in the primary auditory cortex of awake cats. BMC Neuroscience, 10:10, 2009


Ozawa, K., Koike, Y., Wakagi, H., Sato, Y., and Chimoto, S.: Modeling the slope sensitivity of primary auditory cortex neurons in awake cats. Proc. of the 20th IASTED International Conference on Modeling and Simulation (MS 2009), 106-111, 2009



<2008>

Kitamura, K., Judkewitz, B., Kano, M., Denk, W. & Hausser, M.: Targeted patch-clamp recordings and single-cell electroporation of unlabeled neurons in vivo. Nat. Methods 5: 61-67 (2008).



<2007>

Tsukasaki, Y., Kitamura, K., Shimizu, K., Iwane, A. H., Takai, Y. & Yanagida, T.: Role of multiple bonds between the single cell adhesion molecules, nectin and cadherin, revealed by high sensitive force measurements. J. Mol. Biol. 367, 996-1006 (2007).


Okada, T., Tanaka, H., Iwane, A. H., Kitamura, K., Ikebe, M. & Yanagida, T.: The diffusive search mechanisms of processive myosin class-V motor involves directional steps along actin subunits. Biochem. Biophys. Res. Commun., 354, 379-384 (2007).


Qin, L., Chimoto, S., Sakai, M., Wang, J., and Sato, Y.: Comparison between offset and onset responses of primary auditory cortex on-off neurons in awake cats. J. Neurophysiol., 97: 3421-3431, 2007



<2006>

Chimoto, S., Qin, L., Sakai, M., and Sato, Y.: Cortical processing of the slope and level of the sound envelope in awake cats. International conference on the auditory cortex, the listening brain A40 P83, 2006



<2005>

Loewenstein, Y., Mahon, S., Chadderton, P.,  Kitamura, K., Somopolinsky, H., Yarom, Y. & Hausser, M : Bistability of cerebellar Purkinje cells modulated by sensory stimulation. Nat. Neurosci. 8: 201-211 (2005).


Kitamura, K., Tokunaga, M., Esaki, S., Iwane, A. H. & Yanagida, T. : Mechanism of muscle contraction based on stochastic properties of single actomyosin motors observed in vitro. BIOPHYSICS 1: 1-21 (2005).


Qin, L., Sakai, M., Chimoto, S., and Sato, Y.: Interaction of excitatory and inhibitory frequency-receptive fields in determining fundamental frequency sensitivity of primary auditory cortex neurons in awake cats. Cereb Cortex. 15(9):1371-83, 2005



<2004>

Qin, L., Chimoto, S., Sakai, M., and Sato, Y.: Spectral-shape preference of primary auditory cortex neurons in awake cats. Brain Research, 1024: 167-175, 2004


Niwa, M., Chimoto, S., Iwamoto, Y. and Yoshida, K.: Vertical eye movement-related type II neurons with downward on-directions in the vestibular nucleus in alert cats. Exp Brain Res. 155(4): 401-12, 2004


Qin, L., Sakai, M., Chimoto, S. and Sato, Y.: Spectral-edge sensitivity of primary auditory cortex neurons in alert cats. Brain Research, 1014: 1-13, 2004



<2003>

Kitamura, K & Yanagida, T. : Stochastic properties of actomyosin motor. Biosystems 71: 101-10 (2003).


Ishii, Y., Kitamura, K., Tanaka, H. & Yanagida, T. : Molecular motors and single-molecule enzymology. Methods Enzymol. 361: 228-245 (2003).


Chimoto, S., Qin, L., Kitama, T., Sakai, M. and Sato, Y.: Tonal rise-time sensitivity of the primary auditory cortex neurons in alert cat. Proceedings of the international conference on auditory cortex. Towards a synthesis of human and animal research, 19, 2003


Qin, L., Kitama, T., Chimoto, S., Sakayori, S. and Sato, Y.: Time course of tonal frequency-response-area of primary auditory cortex neurons in alert cats. Neuroscience Research, 46: 145-152, 2003



<2002>

Chimoto, S., Kitama, T., Qin, L., Sakayori, S. and Sato, Y.: Tonal response patterns of primary auditory cortex neurons in alert cats. Brain Research, 934: 34-42, 2002


Sakayori, S., Kitama, T., Chimoto, S., Qin, L. and Sato, Y.: Critical spectral regions for vowel identification. Neuroscience Research, 43: 155-162, 2002


Kodaka, Y., Chimoto, S. and Kawano, K.: Neuronal Activity in monkey cortical area 6 during the initial phase of smooth pursuit against a stationary background. Neurobiology of eye movements from molecules to behavior. Annals of the New York academy of science, 956: 460-463, 2002



<2001>

Kitamura, K., Ishijima, A., Tokunaga, M. & Yanagida, T. : Single-Molecule Nanobiotechnology. JSAP International 4: 4-9 (2001).


Yoshida, K., Iwamoto, Y., Chimoto, S. and Shimazu H.: Disynaptic inhibition of omnipause neurons following electrical stimulation of the superior colliculus in alert cats. J. Neurophysiol., 85: 2639-2642, 2001




<2000>

Yanagida, T., Kitamura, K., Tanaka, H., Iwane A. H. & Esaki, S.: Single molecule analysis of the actomyosin motor Cur. Opin. Cell Biol. 12: 20-25 (2000).


Yanagida, T., Esaki, S., Iwane, A. H., Inoue, Y., Ishijima, A., Kitamura, K., Tanaka H. & Tokunaga, M.: Single-motor mechanics and models of the myosin motor. Phil. Trans. R. Soc. Lond. B 355: 441-447 (2000).


Ishii, Y.,  Kimura, Y., Kitamura, K., Tanaka, H., Wazawa T., & Yanagida, T.: Imaging and Nano-manipulation of Single Actomyosin Motors at Work. Clin. Exp. Pharm. Physiol. 27: 229-237 (2000).



<1999>

Kitamura, K., Tokunaga, M., Iwane A. H. & Yanagida, T. : A single myosin head moves along an actin filament with regular steps of 5.3 nanometres. Nature 397: 129-134 (1999).


Yoshida, K., Iwamoto, Y., Chimoto, S. and Shimazu H.: Saccade-related inhibitory input to pontine omnipause neurons: An intracellular study in alert cats. J. Neurophysiol., 82: 1198-1208, 1999


Chimoto, S., Iwamoto, Y. and Yoshida, K.: Projections and firing properties of vertical eye movement-related neurons with downward on-directions in the interstitial nucleus of Cajal in cat.  J. Neurophysiol. 81: 1199-1211, 1999



<1997>

Tokunakga, M., Kitamura, K., Saito, K., Iwane, A. H. & Yanagida, T. : Single Molecule Imaging of Fluorophores and Enzymatic Reactions Achieved by Objective-type Total Internal Reflection Fluorescence Microscopy. Biochem. Biophys. Res. Commun. 235: 47-53 (1997).


Iwane, A. H., Kitamura, K., Tokunakga M., & Yanagida, T. : Myosin Subfragment-1 Is Fully Equipped with Factors Essential for Motor Function. Biochem. Biophys. Res. Commun. 230: 76-80 (1997).


Aoki, T., Hiroshima, M., Kitamura, K., Tokunaga, M. & Yanagida, T. : Non-contact scanning probe microscopy with sub-piconewton force sensitivity. Ultramicroscopy 70: 45-55 (1997).


Tokunaga, M., Aoki, T., Hiroshima, M., Kitamura, K. & Yanagida, T. : Subpiconewton Intermolecular Force Microscopy. Biochem. Biophys. Res. Commun. 231: 566-569 (1997).




Chimoto, S., Iwamoto, Y., Shimazu, H. and Yoshida, K.: Monosynaptic activation of medium-lead burst neurons from the superior colliculus in the alert cat. J. Neurophysiol. Vol.75, No.6, 2658-2661, 1996


Chimoto, S., Iwamoto, Y., Shimazu, H. and Yoshida, K.: Functional connectivity of the superior colliculus with saccade-related brain stem neurons in the cat. In: Extrageniculostriate Mechanisms Underlying Visually-guided Orientation Behavior (Eds.) M. Norita, T. Bando and B. E. H. Stein, Progress in Brain Research, Elsevier, Amsterdam, Vol.112, 157-165, 1996


Chimoto, S., Iwamoto, Y. and Yoshida, K.: Projections of vertical eye movement-related neurons in the interstitial nucleus of Cajal to the vestibular nucleus in the cat.  Neuroscience Research, 15:293-298, 1992