Publications
ここでは当講座の所属員として論文がpublishされたもののみをリストアップしています。
宮澤の着任前のものも含むpublicationはこちら
2007年3月に定年退職された、前任の劒邦夫教授が主宰していた時のpublicationは
こちら 
2019  
19-02 Sakai S, Ohhata T, Kitagawa K, Uchida C, Aoshima T, Niida H, Suzuki T, Inoue Y, Miyazawa K, Kitagawa M.
Long noncoding RNA ELIT-1 acts as a Smad3 cofactor to facilitate TGF-β/Smad signaling and promote epithelial-mesenchymal transition.

Cancer Res. 2019 Apr 5. pii: canres.3210.2018.

19-01 Tsuzuki K, Itoh Y, Inoue Y, Hayashi H.
TRB1 negatively regulatesgluconeogenesis by suppressing the transcriptional activity of FOXO1.

FEBS Lett. 2019 Feb;593(3):369-380.

2018  
18-04 Suzuki K, Kawataki T, Endo K, Miyazawa K, Kinouchi H, Saitoh M.
Expression of ZEBs in gliomas is associated with invasive properties and histopathological grade.

Oncol Lett. 2018 Aug;16(2):1758-1764.

18-03 Nakamura R, Ishii H, Endo K, Hotta A, Fujii E, Miyazawa K, Saitoh M.
Reciprocal expression of Slug and Snail in human oral cancer cells.

PLoS One. 2018 Jul 3;13(7):e0199442.

18-02 Saitoh M.
Involvement of partial EMT in cancer progression.

J Biochem. 2018 Oct 1;164(4):257-264.

18-01 Itoh Y, Saitoh M, Miyazawa K.
Smad3-STAT3 crosstalk in pathophysiological contexts.

Acta Biochim Biophys Sin (Shanghai). 2018 Jan 1;50(1):82-90.

2017  
17-06  Furuya S, Endo K, Takahashi A, Miyazawa K,Saitoh M.
Snail suppresses cellular senescence and promotes fibroblast-led cancer cell invasion.

FEBS Open Bio. 2017 Sep 11;7(10):1586-1597.

17-05  Hayakawa A, Saitoh M, Miyazawa K.
Dual Roles for Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) in Cancer Progression.

Adv Exp Med Biol. 2017 Jun;925:33-40.

17-04  Sinh ND, Endo K, Miyazawa K, Saitoh M.
Ets1 and ESE1 reciprocally regulate expression of ZEB1/ZEB2, dependently on ERK1/2 activity, in breast cancer cells.

Cancer Sci.2017 May;108(5):952-960.

17-03  Okita Y, Kimura M, Xie R, Chen C, Shen LT, Kojima Y, Suzuki H, Muratani M, Saitoh M, Semba K, Heldin CH, Kato M.
The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB.

Sci Signal. 2017 Apr 11;10(474)

17-02  Makino Y, Yoon JH, Bae E, Kato M, Miyazawa K, Ohira T, Ikeda N, Kuroda M, Mamura M.
Repression of Smad3 by Stat3 and c-Ski/SnoN induces gefitinib resistance in lung adenocarcinoma.

Biochem Biophys Res Commun. 2017 Mar 4;484(2):269-277.

17-01  Miyazawa K, Miyazono K.
Regulation of TGF-β Family Signaling by Inhibitory Smads.

Cold Spring Harb Perspect Biol. 2017 Mar 1;9(3). a022095.

2016  
16-03  Kayamori K, Katsube K, Sakamoto K, Ohyama Y, Hirai H, Yukimori A, Ohata Y, Akashi T, Saitoh M, Harada K, Harada H, Yamaguchi A.
NOTCH3 Is Induced in Cancer-Associated Fibroblasts and Promotes Angiogenesis in Oral Squamous Cell Carcinoma.

PLoS One. 2016 Apr 28;11(4):e0154112.

16-02  Saitoh M, Endo K, Furuya S, Minami M, Fukasawa A, Imamura T, Miyazawa K
STAT3 integrates cooperative Ras and TGF-β signals that induce Snail expression.

Oncogene. 2016 Feb 25;35(8):1049-57

16-01  Hoshi Y, Endo K, Shirakihara T, Fukagawa A, Miyazawa K, Saitoh M
The potential role of regulator of G-protein signaling 16 in cell motility mediated by ヲトEF1 family proteins.

FEBS Lett. 2016 Jan;590(2):270-8.

2015  
15-05  Motizuki M, Saitoh M, Miyazawa K
Maid is a negative regulator of transforming growth factor-β-induced cell migration.

J Biochem. 2015 Nov;158(5):435-44.

15-04  Tsubakihara Y, Hikita A, Yamamoto S, Matsushita S, Matsushita N, Oshima Y,Miyazawa K, Imamura T
Arkadia enhances BMP signaling through ubiquitylation and degradation of Smad6.

J Biochem. 2015 Jul;158(1):61-71.

15-03  Saitoh M
Epithelial-mesenchymal transition is regulated at post-transcriptional levels by transforming growth factor-β signaling during tumor progression.

Cancer Sci. 2015 May;106(5):481-8.

15-02  Kawasaki T, Ishida M, Tada T, Matsuya H, Saitoh M, Sato A, Suzuki M, Sugimoto R, Mue Y, Uesugi N, Ishida K, Ishida K, Ariga H, Ichihara S, Sugai T, Sapino A.
Well-differentiated neuroendocrine tumor of the breast with recurrence due to needle tract seeding.

Virchows Arch. 2015 Apr;466(4):479-81.

15-01  Fukagawa A, Ishii H, Miyazawa K, Saitoh M.
δEF1 associates with DNMT1 and maintains DNA methylation of the E-cadherin promoter in breast cancer cells.

Cancer Med. 2015 Jan;4(1):125-35.

2014  
14-03  Ishii H, Saitoh M, Sakamoto K, Kondo T, Katoh R, Tanaka S, Motizuki M, Masuyama K, Miyazawa K.
Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) Suppress Cancer Cell Motility via Different Mechanisms.

J Biol Chem. 2014 Oct 3;289(40):27386-99.

14-02  Isogaya K, Koinuma D, Tsutsumi S, Saito RA, Miyazawa K, Aburatani H, Miyazono K.
A Smad3 and TTF-1/NKX2-1 complex regulates Smad4-independent gene expression.

Cell Res. 2014 Aug;24(8):994-1008.

14-01  Huang M, Xu Q, Mitsui K,Xu Z.
PSK1 regulates expression of SOD1 involved in oxidative stress tolerance in yeast.

FEMS Microbiol Lett. 2014 Jan;350(2):154-60.

2013  
13-05  Sakata K, Hara M, Terada T, Watanabe N, Takaya D, Yaguchi S, Matsumoto T, Matsuura T, Shirouzu M, Yokoyama S, Yamaguchi T, Miyazawa K , Aizaki H, Suzuki T, Wakita T, Imoto M, Kojima S.
HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-β type I receptor.

Sci Rep. 2013 Nov 22;3:3243.

13-04  Shirakihara T, Kawasaki T, Fukagawa A, Semba K, Sakai R, Miyazono K, Miyazawa K, Saitoh M.
Identification of integrin α3 as a molecular marker of cells undergoing EMT and of cancer cells with aggressive phenotypes.

Cancer Sci. 2013 Sep;104(9):1189-97.

13-03  Motizuki M, Isogaya K, Miyake K, Ikushima H, Kubota T, Miyazono K, Saitoh M, Miyazawa K.
Oligodendrocyte transcription factor 1 (Olig1) is a Smad cofactor involved in cell motility induced by transforming growth factor-β

J Biol Chem. 2013 Jun 28;288(26):18911-22.

13-02  Saitoh M, Shirakihara T, Fukasawa A, Horiguchi K, Sakamoto K, Sugiya H, Beppu H, Fujita Y, Morita I, Miyazono K, Miyazawa K.
Basolateral BMP Signaling in Polarized Epithelial Cells.

PLoS One. 2013 May 13;8(5):e62659.

13-01  Miyazawa K.
Phosphoinositide 5-phosphatases: How do they affect tumourigenesis?

J Biochem. 2013 Jan;153(1):1-3. [Commentary]

2012  
12-05  Miyazawa K.
A negative regulator or just an unconcerned passerby: phosphoinositide 3-kinase signalling in IL-12 production.

J Biochem. 2012 Dec;152(6):497-9. [Commentary]

12-04  Saitoh M, Miyazawa K.
Transcriptional and post-transcriptional regulation in TGF-β-mediated epithelial-mesenchymal transition.

J Biochem. 2012 Jun;151(6): 563-571. [Review]

12-03  Horiguchi K, Sakamoto K, Koinuma D, Semba K, Inoue A, Inoue S, Fujii H, Yamaguchi A, Miyazawa K, Miyazono K, Saitoh M.
TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP.

Oncogene. 2012 Jun 28;31(26):3190-201.

12-02  Miyazawa K.
Phosphorylation in the activation loop as the finishing touch in c-Kit activation.

J Biochem. 2012 May;151(5):457-9. [Commentary]

12-01  Ishii R, Isogaya K, Seto A, Koinuma D, Watanabe Y, Arisaka F, Yaguchi SI, Ikushima H, Dohmae N, Miyazono K, Miyazawa K, Ishitani R, Nureki O.
Structure of a dominant-negative helix-loop-helix transcriptional regulator suggests mechanisms of autoinhibition.
EMBO J. 2012 Mar 27;31(11):2541-52.

2011  
11-07  Ikushima H, Todo T, Ino Y, Takahashi M, Saito N, Miyazawa K, Miyazono K.
Glioma-initiating Cells Retain Their Tumorigenicity through Integration of the Sox Axis and Oct4 protein.

J. Biol. Chem. 2011 Dec 2;286(48):41434-41.

11-06  Kawasaki K, and Miyazawa K.
Dissecting the signal transduction pathway that directs endothelial differentiation using embryonic stem cell-derived vascular progenitor cells.

Embryonic Stem Cells -- Differentiation and Pluripotent Alternatives (ed. ByMichael S. Kallos) pp245-266, In Tech, Rijeka (Croatia), 2011 [book chapter]

11-05  Koinuma D, Shinozaki M, Nagano Y, Ikushima H, Horiguchi K, Goto K, Chano T, Saitoh M, Imamura T, Miyazono K, Miyazawa K.
RB1CC1 protein positively regulates transforming growth factor-beta signaling through the modulation of Arkadia E3 ubiquitin ligase activity.

J Biol Chem. 2011 Sep 16;286(37):32502-12.

11-04  Miyazawa K.
Encountering unpredicted off-target effects of pharmacological inhibitors.

J Biochem. 2011 Jul;150(1):1-3. [Commentary]

11-03  Ouyang Y, Xu Q, Mitsui K, Motizuki M, Xu Z.
PSK2 coordinates glucose metabolism and utilization to maintain Ultradian clock-coupled respiratory oscillation in Saccharomyces cerevisiae yeast.

Arch Biochem Biophys. 2011 May 1;509(1):52-8.

11-02  Inoue Y, Iemura SI, Natsume T, Miyazawa K, Imamura T.
Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1.

J Biol Chem. 2011 Feb 25;286(8):6311-20.

11-01 Shirakihara T, Horiguchi K, Miyazawa K, Ehata S, Shibata T, Morita I, Miyazono K, Saitoh M.
TGF-beta regulates FGF receptor isoform switching and epithelial-mesenchymal transition.
EMBO J. 2011 Feb 16;30(4):783-95.

2010  
10-05  Mizutani A, Saitoh M, Imamura T, Miyazawa K, Miyazono K.
Arkadia complexes with clathrin adaptor AP2 and regulates EGF signalling.
J Biochem. 2010 Dec;148(6):733-41.

10-04  Kamiya Y, Miyazono K, Miyazawa K.
Smad7 inhibits transforming growth factor-beta family type i receptors through two distinct modes of interaction.

J Biol Chem. 2010 Oct 1;285(40):30804-13.

10-03 Nagata M, Nagata S, Yuki K, Isogaya K, Saitoh M, Miyazono K, Miyazawa K.
Identification of a phosphorylation site in c-Ski as serine 515.
J Biochem. 2010 Oct;148(4):423-7.

10-02 Miyazawa K.
Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor.
FEBS J. 2010 May;277(10):2208-14.
 [Review]


10-01  Nagano Y, Koinuma D, Miyazawa K, Miyazono K.
Context-dependent regulation of the expression of c-Ski protein by Arkadia in human cancer cells.

J Biochem. 2010 Apr;147(4):545-54.

2009  
 09-03 Hanyu A, Kojima K, Hatake K, Nomura K, Murayama H, Ishikawa Y, Miyata S, Ushijima M, Matsuura M, Ogata E, Miyazawa K, Imamura T.
Functional in vivo optical imaging of tumor angiogenesis, growth and metastasis prevented by administration of anti-human VEGF antibody in xenograft model of human fibrosarcoma HT1080 cells.
Cancer Sci. 2009 Nov;100(11):2085-92.


 09-02 Motizuki M. and Xu Z.
Importance of polarisome proteins in reorganization of actin cytoskelton at low pH in Sacchromyces cerevisiae.
J Biochem. 2009 Nov;146(5):705-12.

 09-01 Ouyang Y, Xu Q, Mitsui K, Motizuki M, Xu Z.
Human trehalase is a stress responsive protein in Saccharomyces cerevisiae.
Biochem Biophys Res Commun. 2009 Feb 6;379(2):621-5.

山梨大学医学部・大学院総合研究部・医学域 生化学講座第2教室

Home