| Publications ここでは当講座の所属員として論文がpublishされたもののみをリストアップしています。 2007年3月に定年退職された、前任の劒邦夫教授が主宰していた時のpublicationはこちら |
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| 2023 | |
| 23-02 | Yokoyama T, Kuga T, Itoh Y, Otake S, Omata C, Saitoh M, Miyazawa K. Smad2Δexon3 and Smad3 have distinct properties in signal transmission leading to TGF-β-induced cell motility. J Biol Chem. 2023 Feb;299(2):102820. |
| 23-01 | Itoh Y, Sawaguchi T, Fu H, Omata C, Saitoh M, Miyazawa K. Indole-derived compound SIS3 targets a subset of activated Smad complexes. J Biochem. 2023 Mar 31;173(4):283-291. |
| 2022 | |
| 22-04 | Yan X, Zhang L, Miyazawa K, Ten Dijke P. Editorial: TGF-β and BMP signaling in cancer. Front Cell Dev Biol. 2022 Sep 2;10:1012326. |
| 22-03 | Ichikawa MK, Endo K, Itoh Y, Osada AH, Kimura Y, Ueki K, Yoshizawa K, Miyazawa K, Saitoh M. Ets family proteins regulate the EMT transcription factors Snail and ZEB in cancer cells. FEBS Open Bio. 2022 Jul;12(7):1353-1364. |
| 22-02 | Ogami T, Tamura Y, Toss K, Yuki K, Morikawa M, Tsutsumi S, Aburatani H, Miyazawa K, Miyazono K, Koinuma D. MAB21L4 regulates the TGF-β-induced expression of target genes in epidermal keratinocytes. J Biochem. 2022 Mar 31;171(4):399-410. |
| 22-01 | Fujioka D, Watanabe Y, Nakamura T, Yokoyama T, Miyazawa K, Murakami M, Kugiyama K. Group V Secretory Phospholipase A2 Regulates Endocytosis of Acetylated LDL by Transcriptional Activation of PGK1 in RAW264.7 Macrophage Cell Line. Atheroscler Thromb. 2022 May 1;29(5):692-718. |
| 2021 | |
| 21-04 | Motizuki M, Koinuma D, Yokoyama T, Itoh Y, Omata C, Miyazono K, Saitoh M, Miyazawa K. TGF-β-induced cell motility requires down-regulation of ARHGAPs to sustain Rac1 activity. J Biol Chem. 2021 Mar 16:100545. |
| 21-03 | Sakamoto K, Endo K, Sakamoto K, Kayamori K, Ehata S, Ichikawa J, Ando T, Nakamura R, Kimura Y,
Yoshizawa K, Masuyama K, Kawataki T, Miyake K, Ishii H, Kawasaki T, Miyazawa K, Saitoh M. EHF suppresses cancer progression by inhibiting ETS1-mediated ZEB expression. Oncogenesis. 2021 Mar 12;10(3):26. |
| 21-02 | Otake S, Itoh Y, Omata C, Saitoh M, Miyazawa K. ZEB1 and oncogenic Ras constitute a regulatory switch for stimulus-dependent E-cadherin downregulation. Cancer Sci. 2021 Jan;112(1):205-216. |
| 21-01 | Takahashi K, Ehata S, Miyauchi K, Morishita Y, Miyazawa K, Miyazono K. Neurotensin receptor 1 signaling promotes pancreatic cancer progression. Mol Oncol. 2021 Jan;15(1):151-166. |
| 2020 | |
| 20-05 | Murayama K, Kato-Murayama M, Itoh Y, Miyazono K, Miyazawa K, Shirouzu M. Structural basis for inhibitory effects of Smad7 on TGF-β family signaling. J Struct Biol. 2020 Dec 1;212(3):107661. |
| 20-04 | Ichikawa J, Ando T, Kawasaki T, Sasaki T, Shirai T, Tsukiji N, Kimura Y, Aoki K, Hayakawa K, Suzuki-Inoue K, Saitoh M, Haro H. Role of Platelet C-Type Lectin-Like Receptor 2 in Promoting Lung Metastasis in Osteosarcoma. J Bone Miner Res. 2020 Sep;35(9):1738-1750. |
| 20-03 | Nakano N, Sakata N, Katsu Y, Nochise D, Sato E, Takahashi Y, Yamaguchi S, Haga Y, Ikeno S, Motizuki M, Sano K, Yamasaki K, Miyazawa K, Itoh S. Dissociation of the AhR/ARNT complex by TGF-β/Smad signaling represses CYP1A1 gene expression and inhibits benze[a]pyrene-mediated cytotoxicity. J Biol Chem. 2020 Jul 3;295(27):9033-9051. |
| 20-02 | Shibata N, Ohoka N, Tsuji G, Demizu Y, Miyawaza K, Ui-Tei K, Akiyama T, Naito M. Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells. Oncogene. 2020;39(19):3867‐3878. |
| 20-01 | Ishii H, Saitoh M, Sakamoto K, Sakamoto K, Saigusa D, Kasai H, Ashizawa K, Miyazawa K, Takeda S, Masuyama K, Yoshimura K. Lipidome-based rapid diagnosis with machine learning for detection of TGF-β signalling activated area in head and neck cancer. Br J Cancer. 2020 Mar;122(7):995-1004. |
| 2019 | |
| 19-06 | Stinchfield MJ, Miyazawa K, Newfeld SJ. Transgenic Analyses in Drosophila Reveal That mCORL1 Is Functionally Distinct from mCORL2 and dCORL. G3 (Bethesda). 2019 Nov 5;9(11):3781-3789. |
| 19-05 | Osada AH, Endo K, Kimura Y, Sakamoto K, Nakamura R, Sakamoto K, Ueki K, Yoshizawa K, Miyazawa K, Saitoh M. Addiction of mesenchymal phenotypes on the FGF/FGFR axis in oral squamous cell carcinoma cells. PLoS One. 2019 Nov 4;14(11):e0217451. |
| 19-04 | Itoh Y, Koinuma D, Omata C, Ogami T, Motizuki M, Yaguchi SI, Itoh T, Miyake K, Tsutsumi S, Aburatani H, Saitoh M, Miyazono K, Miyazawa K. A comparative analysis of Smad-responsive motifs identifies multiple regulatory inputs for TGF-β transcriptional activation. J Biol Chem. 2019 Oct 18;294(42):15466-15479. |
| 19-03 | Nishikawa S, Itoh Y, Tokugawa M, Inoue Y, Nakashima KI, Hori Y, Miyajima C, Yoshida K, Morishita D, Ohoka N, Inoue M, Mizukami H, Makino T, Hayashi H. Kurarinone from Sophora Flavescens Roots Triggers ATF4 Activation and Cytostatic Effects Through PERK Phosphorylation. Molecules. 2019 Aug 27;24(17); E3110. |
| 19-02 | Sakai S, Ohhata T, Kitagawa K, Uchida C, Aoshima T, Niida H, Suzuki T, Inoue Y, Miyazawa K, Kitagawa M. Long noncoding RNA ELIT-1 acts as a Smad3 cofactor to facilitate TGF-β/Smad signaling and promote epithelial-mesenchymal transition. Cancer Res. 2019 Jun 1;79(11):2821-2838. |
| 19-01 | Tsuzuki K, Itoh Y, Inoue Y, Hayashi H. TRB1 negatively regulatesgluconeogenesis by suppressing the transcriptional activity of FOXO1. FEBS Lett. 2019 Feb; 593(3):369-380. |
| 2018 | |
| 18-04 | Suzuki K, Kawataki T, Endo K, Miyazawa K, Kinouchi H, Saitoh M. Expression of ZEBs in gliomas is associated with invasive properties and histopathological grade. Oncol Lett. 2018 Aug;16(2):1758-1764. |
| 18-03 | Nakamura R, Ishii H, Endo K, Hotta A, Fujii E, Miyazawa K, Saitoh M. Reciprocal expression of Slug and Snail in human oral cancer cells. PLoS One. 2018 Jul 3;13(7):e0199442. |
| 18-02 | Saitoh M. Involvement of partial EMT in cancer progression. J Biochem. 2018 Oct 1;164(4):257-264. |
| 18-01 | Itoh Y, Saitoh M, Miyazawa K. Smad3-STAT3 crosstalk in pathophysiological contexts. Acta Biochim Biophys Sin (Shanghai). 2018 Jan 1;50(1):82-90. |
| 2017 | |
| 17-06 | Furuya S, Endo K, Takahashi A, Miyazawa K,Saitoh M. Snail suppresses cellular senescence and promotes fibroblast-led cancer cell invasion. FEBS Open Bio. 2017 Sep 11;7(10):1586-1597. |
| 17-05 | Hayakawa A, Saitoh M, Miyazawa K. Dual Roles for Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) in Cancer Progression. Adv Exp Med Biol. 2017 Jun;925:33-40. |
| 17-04 | Sinh ND, Endo K, Miyazawa K, Saitoh M. Ets1 and ESE1 reciprocally regulate expression of ZEB1/ZEB2, dependently on ERK1/2 activity, in breast cancer cells. Cancer Sci.2017 May;108(5):952-960. |
| 17-03 | Okita Y, Kimura M, Xie R, Chen C, Shen LT, Kojima Y, Suzuki H, Muratani M, Saitoh M, Semba K, Heldin CH, Kato M. The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB. Sci Signal. 2017 Apr 11;10(474) |
| 17-02 | Makino Y, Yoon JH, Bae E, Kato M, Miyazawa K, Ohira T, Ikeda N, Kuroda M, Mamura M. Repression of Smad3 by Stat3 and c-Ski/SnoN induces gefitinib resistance in lung adenocarcinoma. Biochem Biophys Res Commun. 2017 Mar 4;484(2):269-277. |
| 17-01 | Miyazawa K, Miyazono K. Regulation of TGF-β Family Signaling by Inhibitory Smads. Cold Spring Harb Perspect Biol. 2017 Mar 1;9(3). a022095. |
| 2016 | |
| 16-03 | Kayamori K, Katsube K, Sakamoto K, Ohyama Y, Hirai H, Yukimori A, Ohata Y, Akashi T, Saitoh M, Harada K, Harada H, Yamaguchi A. NOTCH3 Is Induced in Cancer-Associated Fibroblasts and Promotes Angiogenesis in Oral Squamous Cell Carcinoma. PLoS One. 2016 Apr 28;11(4):e0154112. |
| 16-02 | Saitoh M, Endo K, Furuya S, Minami M, Fukasawa A, Imamura T, Miyazawa K STAT3 integrates cooperative Ras and TGF-β signals that induce Snail expression. Oncogene. 2016 Feb 25;35(8):1049-57 |
| 16-01 | Hoshi Y, Endo K, Shirakihara T, Fukagawa A, Miyazawa K, Saitoh M The potential role of regulator of G-protein signaling 16 in cell motility mediated by ｦﾄEF1 family proteins. FEBS Lett. 2016 Jan;590(2):270-8. |
| 2015 | |
| 15-05 | Motizuki M, Saitoh M, Miyazawa K Maid is a negative regulator of transforming growth factor-β-induced cell migration. J Biochem. 2015 Nov;158(5):435-44. |
| 15-04 | Tsubakihara Y, Hikita A, Yamamoto S, Matsushita S, Matsushita N, Oshima Y,Miyazawa K, Imamura T Arkadia enhances BMP signaling through ubiquitylation and degradation of Smad6. J Biochem. 2015 Jul;158(1):61-71. |
| 15-03 | Saitoh M Epithelial-mesenchymal transition is regulated at post-transcriptional levels by transforming growth factor-β signaling during tumor progression. Cancer Sci. 2015 May;106(5):481-8. |
| 15-02 | Kawasaki T, Ishida M, Tada T, Matsuya H, Saitoh M, Sato A, Suzuki M, Sugimoto R, Mue Y, Uesugi N, Ishida K, Ishida K, Ariga H, Ichihara S, Sugai T, Sapino A. Well-differentiated neuroendocrine tumor of the breast with recurrence due to needle tract seeding. Virchows Arch. 2015 Apr;466(4):479-81. |
| 15-01 | Fukagawa A, Ishii H, Miyazawa K, Saitoh M. δEF1 associates with DNMT1 and maintains DNA methylation of the E-cadherin promoter in breast cancer cells. Cancer Med. 2015 Jan;4(1):125-35. |
| 2014 | |
| 14-03 | Ishii H, Saitoh M, Sakamoto K, Kondo T, Katoh R, Tanaka S, Motizuki M, Masuyama K, Miyazawa K. Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) Suppress Cancer Cell Motility via Different Mechanisms. J Biol Chem. 2014 Oct 3;289(40):27386-99. |
| 14-02 | Isogaya K, Koinuma D, Tsutsumi S, Saito RA, Miyazawa K, Aburatani H, Miyazono K. A Smad3 and TTF-1/NKX2-1 complex regulates Smad4-independent gene expression. Cell Res. 2014 Aug;24(8):994-1008. |
| 14-01 | Huang M, Xu Q, Mitsui K,Xu Z. PSK1 regulates expression of SOD1 involved in oxidative stress tolerance in yeast. FEMS Microbiol Lett. 2014 Jan;350(2):154-60. |
| 2013 | |
| 13-05 | Sakata K, Hara M, Terada T, Watanabe N, Takaya D, Yaguchi S, Matsumoto T, Matsuura T, Shirouzu M, Yokoyama S, Yamaguchi T, Miyazawa K , Aizaki H, Suzuki T, Wakita T, Imoto M, Kojima S. HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-β type I receptor. Sci Rep. 2013 Nov 22;3:3243. |
| 13-04 | Shirakihara T, Kawasaki T, Fukagawa A, Semba K, Sakai R, Miyazono K, Miyazawa K, Saitoh M. Identification of integrin α3 as a molecular marker of cells undergoing EMT and of cancer cells with aggressive phenotypes. Cancer Sci. 2013 Sep;104(9):1189-97. |
| 13-03 | Motizuki M, Isogaya K, Miyake K, Ikushima H, Kubota T, Miyazono K, Saitoh M, Miyazawa K. Oligodendrocyte transcription factor 1 (Olig1) is a Smad cofactor involved in cell motility induced by transforming growth factor-β J Biol Chem. 2013 Jun 28;288(26):18911-22. |
| 13-02 | Saitoh M, Shirakihara T, Fukasawa A, Horiguchi K, Sakamoto K, Sugiya H, Beppu H, Fujita Y, Morita I, Miyazono K, Miyazawa K. Basolateral BMP Signaling in Polarized Epithelial Cells. PLoS One. 2013 May 13;8(5):e62659. |
| 13-01 | Miyazawa K. Phosphoinositide 5-phosphatases: How do they affect tumourigenesis? J Biochem. 2013 Jan;153(1):1-3. [Commentary] |
| 2012 | |
| 12-05 | Miyazawa K. A negative regulator or just an unconcerned passerby: phosphoinositide 3-kinase signalling in IL-12 production. J Biochem. 2012 Dec;152(6):497-9. [Commentary] |
| 12-04 | Saitoh M, Miyazawa K. Transcriptional and post-transcriptional regulation in TGF-β-mediated epithelial-mesenchymal transition. J Biochem. 2012 Jun;151(6): 563-571. [Review] |
| 12-03 | Horiguchi K, Sakamoto K, Koinuma D, Semba K, Inoue A, Inoue S, Fujii H,
Yamaguchi A, Miyazawa K, Miyazono K, Saitoh M. TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP. Oncogene. 2012 Jun 28;31(26):3190-201. |
| 12-02 | Miyazawa K. Phosphorylation in the activation loop as the finishing touch in c-Kit activation. J Biochem. 2012 May;151(5):457-9. [Commentary] |
| 12-01 | Ishii R, Isogaya K, Seto A, Koinuma D, Watanabe Y, Arisaka F, Yaguchi SI, Ikushima H, Dohmae N, Miyazono K, Miyazawa K, Ishitani R, Nureki O. Structure of a dominant-negative helix-loop-helix transcriptional regulator suggests mechanisms of autoinhibition. EMBO J. 2012 Mar 27;31(11):2541-52. |
| 2011 | |
| 11-07 | Ikushima H, Todo T, Ino Y, Takahashi M, Saito N, Miyazawa K, Miyazono K. Glioma-initiating Cells Retain Their Tumorigenicity through Integration of the Sox Axis and Oct4 protein. J. Biol. Chem. 2011 Dec 2;286(48):41434-41. |
| 11-06 | Kawasaki K, and Miyazawa K. Dissecting the signal transduction pathway that directs endothelial differentiation using embryonic stem cell-derived vascular progenitor cells. Embryonic Stem Cells -- Differentiation and Pluripotent Alternatives (ed. ByMichael S. Kallos) pp245-266, In Tech, Rijeka (Croatia), 2011 [book chapter] |
| 11-05 | Koinuma D, Shinozaki M, Nagano Y, Ikushima H, Horiguchi K, Goto K, Chano
T, Saitoh M, Imamura T, Miyazono K, Miyazawa K. RB1CC1 protein positively regulates transforming growth factor-beta signaling through the modulation of Arkadia E3 ubiquitin ligase activity. J Biol Chem. 2011 Sep 16;286(37):32502-12. |
| 11-04 | Miyazawa K. Encountering unpredicted off-target effects of pharmacological inhibitors. J Biochem. 2011 Jul;150(1):1-3. [Commentary] |
| 11-03 | Ouyang Y, Xu Q, Mitsui K, Motizuki M, Xu Z. PSK2 coordinates glucose metabolism and utilization to maintain Ultradian clock-coupled respiratory oscillation in Saccharomyces cerevisiae yeast. Arch Biochem Biophys. 2011 May 1;509(1):52-8. |
| 11-02 | Inoue Y, Iemura SI, Natsume T, Miyazawa K, Imamura T. Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1. J Biol Chem. 2011 Feb 25;286(8):6311-20. |
| 11-01 | Shirakihara T, Horiguchi K, Miyazawa K, Ehata S, Shibata T, Morita I, Miyazono K, Saitoh M. TGF-beta regulates FGF receptor isoform switching and epithelial-mesenchymal transition. EMBO J. 2011 Feb 16;30(4):783-95. |
| 2010 | |
| 10-05 | Mizutani A, Saitoh M, Imamura T, Miyazawa K, Miyazono K. Arkadia complexes with clathrin adaptor AP2 and regulates EGF signalling. J Biochem. 2010 Dec;148(6):733-41. |
| 10-04 | Kamiya Y, Miyazono K, Miyazawa K. Smad7 inhibits transforming growth factor-beta family type i receptors through two distinct modes of interaction. J Biol Chem. 2010 Oct 1;285(40):30804-13. |
| 10-03 | Nagata M, Nagata S, Yuki K, Isogaya K, Saitoh M, Miyazono K, Miyazawa K. Identification of a phosphorylation site in c-Ski as serine 515. J Biochem. 2010 Oct;148(4):423-7. |
| 10-02 | Miyazawa K. Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor. FEBS J. 2010 May;277(10):2208-14. [Review] |
| 10-01 | Nagano Y, Koinuma D, Miyazawa K, Miyazono K. Context-dependent regulation of the expression of c-Ski protein by Arkadia in human cancer cells. J Biochem. 2010 Apr;147(4):545-54. |
| 2009 | |
| 09-03 | Hanyu A, Kojima K, Hatake K, Nomura K, Murayama H, Ishikawa Y, Miyata S,
Ushijima M, Matsuura M, Ogata E, Miyazawa K, Imamura T. Functional in vivo optical imaging of tumor angiogenesis, growth and metastasis prevented by administration of anti-human VEGF antibody in xenograft model of human fibrosarcoma HT1080 cells. Cancer Sci. 2009 Nov;100(11):2085-92. |
| 09-02 | Motizuki M. and Xu Z. Importance of polarisome proteins in reorganization of actin cytoskelton at low pH in Sacchromyces cerevisiae. J Biochem. 2009 Nov;146(5):705-12. |
| 09-01 | Ouyang Y, Xu Q, Mitsui K, Motizuki M, Xu Z. Human trehalase is a stress responsive protein in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2009 Feb 6;379(2):621-5. |
山梨大学医学部・大学院総合研究部・医学域 生化学講座第２教室