劒邦夫教授が在任中の当教室の業績
研究業績に戻る

08-1 Motizuki M, Yokota S, Tsurugi K.
Effect of low pH on organization of the actin cytoskeleton in Saccharomyces cerevisiae.
Biochim Biophys Acta. 2008 Feb;1780(2):179-84.
07-5 Sun Q, Bi L, Su X, Tsurugi K, Mitsui K.
Valproate induces apoptosis by inducing accumulation of neutral lipids which was prevented by disruption of the SIR2 gene in Saccharomyces cerevisiae.
FEBS Lett. 2007 Aug 21;581(21):3991-5
07-4 Xu Z, Tsurugi K.
Destabilization of energy-metabolism oscillation in the absence of trehalose synthesis in the chemostat culture of yeast.
Arch Biochem Biophys. 2007 Aug 15;464(2):350-8.  
07-3 Yaguchi S, Shen H, Tsurugi K.
Localization of Gts1p in cortical actin patches of yeast and its possible role in endocytosis.
Eur J Cell Biol. 2007 May;86(5):275-85.  
07-2 Xu Z, Tsurugi K.
Role of Gts1p in regulation of energy-metabolism oscillation in continuous cultures of the yeast Saccharomyces cerevisiae.
Yeast. 2007 Mar;24(3):161-70.
07-1 Chen J, Shen H, Nagasawa Y, Mitsui K, Tsurugi K, Hashimoto K.
Pravastatin inhibits arrhythmias induced by coronary artery ischemia in anesthetized rats.
J Pharmacol Sci. 2007 Mar;103(3):317-22.  
06-2 Shen H, Iha H, Yaguchi S, Tsurugi K.
The mechanism by which overexpression of Gts1p induces flocculation in a FLO8-inactive strain of the yeast Saccharomyces cerevisiae.
FEMS Yeast Res. 2006 Sep;6(6):914-23. 
06-1 Xu Z, Tsurugi K.
A potential mechanism of energy-metabolism oscillation in an aerobic chemostat culture of the yeast Saccharomyces cerevisiae.
FEBS J. 2006 Apr;273(8):1696-709.
05-1  Mitsui K, Nakagawa D, Nakamura M, Okamoto T, Tsurugi K.
Valproic acid induces apoptosis dependent of Yca1p at concentrations that mildly affect the proliferation of yeast.
FEBS Lett. 2005 Jan 31;579(3):723-7.
04-2 Xu Z, Yaguchi S, Tsurugi K. 
Gts1p stabilizes oscillations in energy metabolism by activating the transcription of TPS1 encoding trehalose-6-phosphate synthase 1 in the yeast Saccharomyces cerevisiae.
Biochem J. 2004 Oct 1;383(Pt 1):171-8.
04-1 Motizuki M, Takei T, Tasaka K, Yokota S, Kojima S, Haga T, Tsurugi K.
Low pH facilitates uptake of proteins by cells through a non-endocytic pathway.
J Biochem. 2004 Jun;135(6):713-9. 
03-3 Akiyama S, Tsurugi K.
The GTS1 gene product facilitates the self-organization of the energy metabolism oscillation in the continuous culture of the yeast Saccharomyces cerevisiae.
FEMS Microbiol Lett. 2003 Nov 7;228(1):105-10. 
03-2 Abudugupur A, Xu Z, Mitsui K, Hisaki H, Ueda N, Amemiya T, Tsurugi K.
Severe reduction of superoxide dismutase activity in the yeast Saccharomyces cerevisae with the deletion or overexpression of GTS1.
FEMS Microbiol Lett. 2003 Jun 6;223(1):141-5. 
03-1 Yaguchi S, Tsurugi K.
Gts1p activates SNF1-dependent derepression of HSP104 and TPS1 in the stationary phase of yeast growth.
J Biol Chem. 2003 Aug 8;278(32):29760-8.  
02-5 Liu W, Wang J, Mitsui K, Shen H, Tsurugi K.
Interaction of the GTS1 gene product with glyceraldehyde- 3-phosphate dehydrogenase 1 required for the maintenance of the metabolic oscillations of the yeast Saccharomyces cerevisiae.
Eur J Biochem. 2002 Jul;269(14):3560-9. 
02-4 Motizuki M, Satoh T, Takei T, Itoh T, Yokota S, Kojima S, Miura K, Samejima T, Tsurugi K.
Structure-activity analysis of an antimicrobial peptide derived from bovine apolipoprotein A-II.
J Biochem. 2002 Jul;132(1):115-9. 
02-3 Saito T, Mitsui K, Hamada Y, Tsurugi K.
Regulation of the Gts1p level by the ubiquitination system to maintain metabolic oscillations in the continuous culture of yeast.
J Biol Chem. 2002 Sep 13;277(37):33624-31.  
02-2 Uno T, Wang J, Mitsui K, Umetani K, Tamura K, Tsurugi K.
Ultradian rhythm of trehalose levels coupled to heat resistance in continuous cultures of the yeast Saccharomyces cerevisiae.
Chronobiol Int. 2002 Mar;19(2):361-75. 
02-1 Abudugupur A, Mitsui K, Yokota S, Tsurugi K.
An ARL1 mutation affected autophagic cell death in yeast, causing a defect in central vacuole formation.
Cell Death Differ. 2002 Feb;9(2):158-68. 
01-3 Tonozuka H, Wang J, Mitsui K, Saito T, Hamada Y, Tsurugi K.
Analysis of the upstream regulatory region of the GTS1 gene required for its oscillatory expression.
J Biochem. 2001 Nov;130(5):589-95. 
01-2 Iha H, Tezuka H, Yaguchi S, Tsurugi K.
Functional correlation between the nuclear localization of Fht1p and its flocculation and heat tolerance activities in budding yeast Saccharomyces cerevisiae
J Biomed Sci. 2001 Sep;8(5):416-20. 
01-1 Wang J, Liu W, Mitsui K, Tsurugi K.
Evidence for the involvement of the GTS1 gene product in the regulation of biological rhythms in the continuous culture of the yeast Saccharomyces cerevisiae.
FEBS Lett. 2001 Jan 26;489(1):81-6. 
00-3 Iha H, Kasai T, Kibler KV, Iwanaga Y, Tsurugi K, Jeang KT.
Pleiotropic effects of HTLV type 1 Tax protein on cellular metabolism: mitotic checkpoint abrogation and NF-kappaB activation.
AIDS Res Hum Retroviruses. 2000 Nov 1;16(16):1633-8. 
00-2 Wang J, Liu W, Uno T, Tonozuka H, Mitsui K, Tsurugi K.
Cellular stress responses oscillate in synchronization with the ultradian oscillation of energy metabolism in the yeast Saccharomyces cerevisiae.
FEMS Microbiol Lett. 2000 Aug 1;189(1):9-13.
00-1 Yaguchi S, Mitsui K, Iha H, Tsurugi K.
Phosphorylation of the GTS1 gene product of the yeast Saccharomyces cerevisiae and its effect on heat tolerance and flocculation.
FEMS Microbiol Lett. 2000 Jun 15;187(2):179-84. 
99-3 Xu Z, Mitsui K, Motizuki M, Yaguchi SI, Tsurugi K.
The DLP1 mutant of the yeast Saccharomyces cerevisiae with an increased copy number of the 2micron plasmid shows a shortened lifespan.
Mech Ageing Dev. 1999 Oct 1;110(1-2):119-29. 
99-2 Motizuki M, Itoh T, Satoh T, Yokota S, Yamada M, Shimamura S, Samejima T, Tsurugi K.
Lipid-binding and antimicrobial properties of synthetic peptides of bovine apolipoprotein A-II.
Biochem J. 1999 Aug 15;342 ( Pt 1):215-21. 
99-1 Kawabata K, Mitsui K, Uno T, Tamura K, Tsurugi K.
Protein interactions of Gts1p of Saccharomyces cerevisiae throughout a region similar to a cytoplasmic portion of some ATP-binding cassette transporters.
Eur J Biochem. 1999 Jan;259(1-2):112-9.
98-3 Iha H, Tsurugi K.
Shuttle-vector system for Saccharomyces cerevisiae designed to produce C-terminal-Myc-tagged fusion proteins.
Biotechniques. 1998 Dec;25(6):936-8.  
98-2 Motizuki M, Itoh T, Yamada M, Shimamura S, Tsurugi K.
Purification, primary structure, and antimicrobial activities of bovine apolipoprotein A-II.
J Biochem. 1998 Apr;123(4):675-9. 
98-1 Wang J, Mitsui K, Tsurugi K.
The GTS1 gene product influences the ultradian oscillation of glycolysis in cell suspension of the yeast Saccharomyces cerevisiae.
Biochem Biophys Res Commun. 1998 Mar 6;244(1):239-42. 
97-1 Yaguchi S, Mitsui K, Tsurugi K.
Reexamination of the nucleotide sequence of GTS1, a candidate clocl gene of Saccharomyces cerevisiae.
Biochem Arch. 13:97-105 
96-1 Yaguchi S, Mitsui K, Kawabata K, Xu Z, Tsurugi K.
The pleiotropic effect of the GTS1 gene product on heat tolerance, sporulation and the life span of Saccharomyces cerevisiae.
Biochem Biophys Res Commun. 1996 Jan 5;218(1):234-7. 
95-2 Motizuki M, Yokota S, Tsurugi K.
Autophagic death after cell cycle arrest at the restrictive temperature in temperature-sensitive cell division cycle and secretory mutants of the yeast Saccharomyces cerevisiae.
Eur J Cell Biol. 1995 Nov;68(3):275-87. 
95-1 Ueda H, Kobayashi T, Mitsui K, Tsurugi K, Tsukahara S, Ohno S.
Dystrophin localization at presynapse in rat retina revealed by immunoelectron microscopy.
Invest Ophthalmol Vis Sci. 1995 Oct;36(11):2318-22. 
94-2 Saito T, Ikeda M, Endo T, Tsurugi K, Onaya T.
Increased expression of acidic ribosomal protein (P0) mRNA after phorbol ester treatment of cultured rat thyroid (FRTL-5) cells.
Biochem Biophys Res Commun. 1994 Sep 15;203(2):780-8. 
94-1 Mitsui K, Yaguchi S, Tsurugi K.
The GTS1 gene, which contains a Gly-Thr repeat, affects the timing of budding and cell size of the yeast Saccharomyces cerevisiae.
Mol Cell Biol. 1994 Aug;14(8):5569-78. 
93-2 Endo Y, Oka T, Yokota S, Tsurugi K, Natori Y.
The biosynthesis of a cytotoxic protein, alpha-sarcin, in a mold of Aspergillus giganteus. II. Maturation of precursor form of alpha-sarcin in vivo.
Tokushima J Exp Med. 1993 Jun;40(1-2):7-12. 
93-1 Endo Y, Oka T, Tsurugi K, Natori Y.
The biosynthesis of a cytotoxic protein, alpha-sarcin, in a mold Aspergillus giganteus. I. Synthesis of prepro- and pro-alpha-sarcin in vitro.
Tokushima J Exp Med. 1993 Jun;40(1-2):1-6. 
92-3 Motizuki M, Tsurugi K.
The effect of aging on protein synthesis in the yeast Saccharomyces cerevisiae.
Mech Ageing Dev. 1992 Jul 15;64(3):235-45. 
92-2 Motizuki M, Tsurugi K.
Effect of 17 beta-estradiol on the generation time of old cells of the yeast Saccharomyces cerevisiae.
Biochem Biophys Res Commun. 1992 Mar 31;183(3):1191-6. 
92-1 Tsurugi K.
Hydrophobic zippers and hook-and-eye: evolutionarily conserved protein sequence motifs in eukaryotic acidic ribosomal proteins which are assumed to be involved in the association of the protein family.
Protein Seq Data Anal. 1992;5(1):33-8. 
91-2 Ikeda M, Saito T, Endo T, Tsurugi K, Onaya T.
Thyrotropin stimulates the expression of an acidic ribosomal protein, P0, messenger ribonucleic acid in cultured rat thyroid (FRTL) cells.
Endocrinology. 1991 May;128(5):2540-7. 
91-1

Tsurugi K, Mitsui K.
Bilateral hydrophobic zipper as a hypothetical structure which binds acidic ribosomal protein family together on ribosomes in yeast Saccharomyces cerevisiae.
Biochem Biophys Res Commun. 1991 Feb 14;174(3):1318-23. 

90-2 Oka T, Natori Y, Tanaka S, Tsurugi K, Endo Y.
Complete nucleotide sequence of cDNA for the cytotoxin alpha sarcin.
Nucleic Acids Res. 1990 Apr 11;18(7):1897 
90-1 Endo Y, Gl端ck A, Chan YL, Tsurugi K, Wool IG.
RNA-protein interaction. An analysis with RNA oligonucleotides of the recognition by alpha-sarcin of a ribosomal domain critical for function.
J Biol Chem. 1990 Feb 5;265(4):2216-22. 
89-4 Mitsui K, Nakagawa T, Tsurugi K.
The gene and the primary structure of acidic ribosomal protein A0 from yeast Saccharomyces cerevisiae which shows partial homology to bacterial ribosomal protein L10.
J Biochem. 1989 Aug;106(2):223-7.
89-3 Mitsui K, Tsurugi K.
Identification of A1 protein as the fourth member of 13 kDa-type acidic ribosomal protein family in yeast Saccharomyces cerevisiae.
Biochem Biophys Res Commun. 1989 Jun 30;161(3):1001-6. 
89-2 Endo Y, Oka T, Tsurugi K, Franz H.
The mechanism of action of the cytotoxic lectin from Phoradendron californicum: the RNA N-glycosidase activity of the protein.
FEBS Lett. 1989 May 8;248(1-2):115-8. 
89-1

Shiokawa K, Yamazaki T, Fu YC, Tashiro K, Tsurugi K, Motizuki M, Ikegami Y, Araki E, Andoh T, Hosokawa K.
Persistence and expression of circular DNAs encoding Drosophila amylase, bacterial chloramphenicol acetyltransferase, and others in Xenopus laevis embryos.
Cell Struct Funct. 1989 Apr;14(2):261-9. 

88-13 Mitsui K, Nakagawa T, Tsurugi K.
On the size and the role of a free cytosolic pool of acidic ribosomal proteins in yeast Saccharomyces cerevisiae.
J Biochem. 1988 Dec;104(6):908-11. 
88-12 Motizuki M, Kohno H, Tsurugi K.
A study on the identities of the three species of chromatin-associated proteinases in a mutant of Saccharomyces cerevisiae which lacks four major vacuolar proteinases.
J Biochem. 1988 Aug;104(2):192-5. 
88-11 Endo Y, Tsurugi K.
The RNA N-glycosidase activity of ricin A-chain. The characteristics of the enzymatic activity of ricin A-chain with ribosomes and with rRNA.
J Biol Chem. 1988 Jun 25;263(18):8735-9. 
88-10 Endo Y, Chan YL, Lin A, Tsurugi K, Wool IG.
The cytotoxins alpha-sarcin and ricin retain their specificity when tested on a synthetic oligoribonucleotide (35-mer) that mimics a region of 28 S ribosomal ribonucleic acid.
J Biol Chem. 1988 Jun 15;263(17):7917-20. 
88-9 Endo Y, Tsurugi K, Ebert RF.
The mechanism of action of barley toxin: a type 1 ribosome-inactivating protein with RNA N-glycosidase activity.
Biochim Biophys Acta. 1988 May 18;954(2):224-6. 
88-8 Endo Y, Tsurugi K, Franz H.
The site of action of the A-chain of mistletoe lectin I on eukaryotic ribosomes. The RNA N-glycosidase activity of the protein.
FEBS Lett. 1988 Apr 25;231(2):378-80. 
88-7 Mitsui K, Tsurugi K.
cDNA and deduced amino acid sequence of acidic ribosomal protein A2 from Saccharomyces cerevisiae.
Nucleic Acids Res. 1988 Apr 25;16(8):3575.  
88-6 Mitsui K, Tsurugi K.
cDNA and deduced amino acid sequence of acidic ribosomal protein A1 from Saccharomyces cerevisiae.
Nucleic Acids Res. 1988 Apr 25;16(8):3574.  
88-5 Mitsui K, Tsurugi K.
cDNA and deduced amino acid sequence of 38 kDa-type acidic ribosomal protein A0 from Saccharomyces cerevisiae.
Nucleic Acids Res. 1988 Apr 25;16(8):3573.
88-4 Endo Y, Tsurugi K, Lambert JM.
The site of action of six different ribosome-inactivating proteins from plants on eukaryotic ribosomes: the RNA N-glycosidase activity of the proteins.
Biochem Biophys Res Commun. 1988 Feb 15;150(3):1032-6.
88-3 Endo Y, Tsurugi K, Yutsudo T, Takeda Y, Ogasawara T, Igarashi K.
Site of action of a Vero toxin (VT2) from Escherichia coli O157:H7 and of Shiga toxin on eukaryotic ribosomes. RNA N-glycosidase activity of the toxins.
Eur J Biochem. 1988 Jan 15;171(1-2):45-50. 
88-2 Tsurugi K, Motizuki M, Mitsui K, Endo Y, Shiokawa K.
The metabolism of ribosomal proteins microinjected into the oocytes of Xenopus laevis.
Exp Cell Res. 1988 Jan;174(1):177-87. 
88-1 Endo Y, Tsurugi K.
The RNA N-glycosidase activity of ricin A-chain.
Nucleic Acids Symp Ser. 1988;(19):139-42. 
87-3 Mitsui K, Motizuki M, Endo Y, Yokota S, Tsurugi K.
Characterization of a novel acidic protein of 38 kDa, A0, in yeast ribosomes which immunologically cross-reacts with the 13 kDa acidic ribosomal proteins, A1/A2.
J Biochem. 1987 Dec;102(6):1565-70. 
87-2 Endo Y, Tsurugi K.
RNA N-glycosidase activity of ricin A-chain. Mechanism of action of the toxic lectin ricin on eukaryotic ribosomes.
J Biol Chem. 1987 Jun 15;262(17):8128-30. 
87-1 Endo Y, Mitsui K, Motizuki M, Tsurugi K.
The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins.
J Biol Chem. 1987 Apr 25;262(12):5908-12. 
86-2 Motizuki M, Mitsui K, Endo Y, Tsurugi K.
Detection and partial characterization of the chromatin-associated proteases of yeast Saccharomyces cerevisiae.
Eur J Biochem. 1986 Jul 15;158(2):345-50.
86-1 Endo Y, Tsurugi K.
Mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes.
Nucleic Acids Symp Ser. 1986;(17):187-90. 

山梨大学医学部・大学院総合研究部・医学域 生化学講座第2教室

フレーム版Home