Publications (Keiji Miyazawa) 劒邦夫教授が在任中の当教室の業績
124 Nakamura R, Ishii H, Endo K, Hotta A, Fujii E, Miyazawa K, Saitoh M.
Reciprocal expression of Slug and Snail in human oral cancer cells.
PLoS One. 2018 Jul 3;13(7):e0199442.
123 Itoh Y, Saitoh M, Miyazawa K.
Smad3-STAT3 crosstalk in pathophysiological contexts.
Acta Biochim Biophys Sin (Shanghai). 2018 Jan 1;50(1):82-90.
122 Furuya S, Endo K, Takahashi A, Miyazawa K, Saitoh M.
Snail suppresses cellular senescence and promotes fibroblast-led cancer cell invasion.
FEBS Open Bio. 2017 Sep 11;7(10):1586-1597.
121 Hayakawa A, Saitoh M, Miyazawa K.
Dual Roles for Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) in Cancer Progression.
Adv Exp Med Biol. 2017 Jun;925:33-40.
120 Sinh ND, Endo K, Miyazawa K, Saitoh M.
Ets1 and ESE1 reciprocally regulate expression of ZEB1/ZEB2, dependently on ERK1/2 activity, in breast cancer cells.
Cancer Sci.2017 May;108(5):952-960.
119 Makino Y, Yoon JH, Bae E, Kato M, Miyazawa K, Ohira T, Ikeda N, Kuroda M, Mamura M.
Repression of Smad3 by Stat3 and c-Ski/SnoN induces gefitinib resistance in lung adenocarcinoma.
Biochem Biophys Res Commun. 2017 Jan 20. pii: S0006-291X(17)30143-2.
118 Miyazawa K, Miyazono K.
Regulation of TGF-ヲツ Family Signaling by Inhibitory Smads.
Cold Spring Harb Perspect Biol. 2016 Dec 5.
117 Hayakawa A, Saitoh M, Miyazawa K.
Dual Roles for Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) in Cancer Progression.
Adv Exp Med Biol. 2016 Jul 12.
116 Saitoh M, Endo K, Furuya S, Minami M, Fukasawa A, Imamura T, Miyazawa K.
STAT3 integrates cooperative Ras and TGF-ヲツ signals that induce Snail expression.
Oncogene. 2016 Feb 25;35(8):1049-57
115 Hoshi Y, Endo K, Shirakihara T, Fukagawa A, Miyazawa K, Saitoh M.
The potential role of regulator of G-protein signaling 16 in cell motility mediated by ヲトEF1 family proteins.
FEBS Lett. 2016 Jan;590(2):270-8.
114 Motizuki M, Saitoh M, Miyazawa K.
Maid is a negative regulator of transforming growth factor-ヲツ-induced cell migration.
J Biochem. 2015 Nov;158(5):435-44.
113 Tsubakihara Y, Hikita A, Yamamoto S, Matsushita S, Matsushita N, Oshima Y,Miyazawa K, Imamura T.
Arkadia enhances BMP signaling through ubiquitylation and degradation of Smad6.
J Biochem. 2015 Jul;158(1):61-71.
112 Fukagawa A, Ishii H, Miyazawa K, Saitoh M.
ヲトEF1 associates with DNMT1 and maintains DNA methylation of the E-cadherin promoter in breast cancer cells.
Cancer Med. 2015 Jan;4(1):125-35.
111 Ishii H, Saitoh M, Sakamoto K, Kondo T, Katoh R, Tanaka S, Motizuki M, Masuyama K, Miyazawa K.
Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) Suppress Cancer Cell Motility via Different Mechanisms.
J Biol Chem. 2014 Oct 3;289(40):27386-99.
110 Isogaya K, Koinuma D, Tsutsumi S, Saito RA, Miyazawa K, Aburatani H, Miyazono K.
A Smad3 and TTF-1/NKX2-1 complex regulates Smad4-independent gene expression.
Cell Res. 2014 Aug;24(8):994-1008.
109 Sakata K, Hara M, Terada T, Watanabe N, Takaya D, Yaguchi S, Matsumoto T, Matsuura T, Shirouzu M, Yokoyama S, Yamaguchi T, Miyazawa K , Aizaki H, Suzuki T, Wakita T, Imoto M, Kojima S.
HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-ヲツ type I receptor.
Sci Rep. 2013 Nov 22;3:3243.
108 Shirakihara T, Kawasaki T, Fukagawa A, Semba K, Sakai R, Miyazono K, Miyazawa K, Saitoh M.
Identification of integrin ヲチ3 as a molecular marker of cells undergoing EMT and of cancer cells with aggressive phenotypes.
Cancer Sci. 2013 Sep;104(9):1189-97.
107 Motizuki M, Isogaya K, Miyake K, Ikushima H, Kubota T, Miyazono K, Saitoh M, Miyazawa K.
Oligodendrocyte transcription factor 1 (Olig1) is a Smad cofactor involved in cell motility induced by transforming growth factor-ヲツ
J Biol Chem. 2013 Jun 28;288(26):18911-22.
106 Saitoh M, Shirakihara T, Fukasawa A, Horiguchi K, Sakamoto K, Sugiya H, Beppu H, Fujita Y, Morita I, Miyazono K, Miyazawa K.
Basolateral BMP Signaling in Polarized Epithelial Cells.
PLoS One. 2013 May 13;8(5):e62659.
105 Miyazawa K.
Phosphoinositide 5-phosphatases: How do they affect tumourigenesis?
J Biochem. 2013 Jan;153(1):1-3. [Commentary]
104 Miyazawa K.
A negative regulator or just an unconcerned passerby: phosphoinositide 3-kinase signalling in IL-12 production.
J Biochem. 2012 Dec;152(6):497-9. [Commentary]
103

Saitoh M, Miyazawa K.
Transcriptional and post-transcriptional regulation in TGF-ヲツ-mediated epithelial-mesenchymal transition.

J Biochem. 2012 Jun;151(6): 563-571. [Review]

102

Ishii R, Isogaya K, Seto A, Koinuma D, Watanabe Y, Arisaka F, Yaguchi SI, Ikushima H, Dohmae N, Miyazono K, Miyazawa K, Ishitani R, Nureki O.
Structure of a dominant-negative helix-loop-helix transcriptional regulator suggests mechanisms of autoinhibition.

EMBO J. 2012 Mar 27;31(11):2541-52.

101

Miyazawa K.
Phosphorylation in the activation loop as the finishing touch in c-Kit activation.

J Biochem. 2012 May;151(5):457-9.

100

Horiguchi K, Sakamoto K, Koinuma D, Semba K, Inoue A, Inoue S, Fujii H, Yamaguchi A, Miyazawa K, Miyazono K, Saitoh M.
TGF-ヲツ drives epithelial-mesenchymal transition through ヲトEF1-mediated downregulation of ESRP.

Oncogene. 2011 Oct 31.

99

Ikushima H, Todo T, Ino Y, Takahashi M, Saito N, Miyazawa K, Miyazono K.
Glioma-initiating Cells Retain Their Tumorigenicity through Integration of the Sox Axis and Oct4.

J. Biol. Chem. 2011 Dec 2;286(48):41434-41.

98

Kawasaki K, and Miyazawa K.
Dissecting the signal transduction pathway that directs endothelial differentiation using embryonic stem cell-derived vascular progenitor cells.

Embryonic Stem Cells -- Differentiation and Pluripotent Alternatives (ed. ByMichael S. Kallos) pp245-266, In Tech, Rijeka (Croatia), 2011 [book chapter]

97

Koinuma D, Shinozaki M, Nagano Y, Ikushima H, Horiguchi K, Goto K, Chano T, Saitoh M, Imamura T, Miyazono K, Miyazawa K.
RB1CC1 protein positively regulates transforming growth factor-beta signaling through the modulation of Arkadia E3 ubiquitin ligase activity.

J Biol Chem. 2011 Sep 16;286(37):32502-12.

96

Miyazawa K.
Encountering unpredicted off-target effects of pharmacological inhibitors.

J Biochem. 2011 Jul;150(1):1-3. [Commentary]

95

Inoue Y, Iemura SI, Natsume T, Miyazawa K, Imamura T.
Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1.
J Biol Chem. 2011 Feb 25;286(8):6311-20.

94 Shirakihara T, Horiguchi K, Miyazawa K, Ehata S, Shibata T, Morita I, Miyazono K, Saitoh M.
TGF-beta regulates FGF receptor isoform switching and epithelial-mesenchymal transition.
EMBO J. 2011 Feb 16;30(4):783-95.
93

Mizutani A, Saitoh M, Imamura T, Miyazawa K, Miyazono K.
Arkadia complexes with clathrin adaptor AP2 and regulates EGF signalling.
J Biochem. 2010 Dec;148(6):733-41.

92

Kamiya Y, Miyazono K, Miyazawa K.
Smad7 inhibits transforming growth factor-beta family type i receptors through two distinct modes of interaction.
J Biol Chem. 2010 Oct 1;285(40):30804-13.

91 Nagata M, Nagata S, Yuki K, Isogaya K, Saitoh M, Miyazono K, Miyazawa K.
Identification of a phosphorylation site in c-Ski as serine 515.
J Biochem. 2010 Oct;148(4):423-7. 
90 Miyazawa K.
Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor.
FEBS J. 2010 May;277(10):2208-14.
 [Review]
89 Nagano Y, Koinuma D, Miyazawa K, Miyazono K.
Context-dependent regulation of the expression of c-Ski protein by Arkadia in human cancer cells.
J Biochem. 2010 Apr;147(4):545-54.
88 Ikushima H, Todo T, Ino T, Takahashi T, Miyazawa K, Miyazono K.
Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors.
Cell Stem Cell. 2009 Nov 6;5(5):504-14.
87 Hanyu A, Kojima K, Hatake K, Nomura K, Murayama H, Ishikawa Y, Miyata S, Ushijima M, Matsuura M, Ogata E, Miyazawa K, Imamura T.
Functional in vivo optical imaging of tumor angiogenesis, growth and metastasis prevented by administration of anti-human VEGF antibody in xenograft model of human fibrosarcoma HT1080 cells.
Cancer Sci. 2009 Nov;100(11):2085-92.
86 Sase, H. Watabe, T., Kawasaki, K., Miyazono, K., Miyazawa, K.
VEGFR2-PLCgamma axisis is essential for endothelial specification of VEGFR2+ vascular progenitor cells.
J Cell Sci. 2009 Sep 15;122(Pt 18):3303-11.
85 Nakano A, Koinuma D, Miyazawa K, Uchida T, Saitoh M, Kawabata M, Hanai J, Akiyama H, Abe M, Miyazono K, Matsumoto T, Imamura T.
Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins.

J Biol Chem. 2009 Mar 6;284(10):6109-15.
84 Feng SM, Muraoka-Cook RS, Hunter D, Sandahl MA, Caskey LS, Miyazawa K, Atfi A, Earp HS 3rd.
The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation.
Mol Cell Biol. 2009 Feb;29(3):892-906.  
83 Takahata M, Inoue Y, Tsuda H, Imoto I, Koinuma D, Hayashi M, Ichikura T, Yamori T, Nagasaki K, Yoshida M, Matsuoka M, Morishita K, Yuki K, Hanyu A, Miyazawa K, Inazawa J, Miyazono K, Imamura T.
SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells.
J Biol Chem. 2009 Jan 30;284(5):3334-44.  
82 Koinuma D, Tsutsumi S, Kamimura N, Taniguchi H, Miyazawa K, Sunamura M, Imamura T, Miyazono K, Aburatani H.
Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling.
Mol Cell Biol. 2009 Jan;29(1):172-86. 
81 Seto A, Ikushima H, Suzuki T, Sato Y, Fukai S, Yuki K, Miyazawa K, Miyazono K, Ishitani R, Nureki O.
Crystallization and preliminary X-ray diffraction analysis of GCIP/HHM transcriptional regulator.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jan 1;65(Pt 1):21-4.  
80 Yuzawa H, Koinuma D, Maeda S, Yamamoto K, Miyazawa K, Imamura T.
Arkadia represses the expression of myoblast differentiation markers through degradation of Ski and the Ski-bound Smad complex in C2C12 myoblasts.
Bone. 2009 Jan;44(1):53-60.  
79 Fukunaga E, Inoue Y, Komiya S, Horiguchi K, Goto K, Saitoh M, Miyazawa K, Koinuma D, Hanyu A, Imamura T.
Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells.
J Biol Chem. 2008 Dec 19;283(51):35660-7.  
78 Ikushima H, Komuro A, Isogaya K, Shinozaki M, Hellman U, Miyazawa K, Miyazono K.
An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-beta signalling.
EMBO J. 2008 Nov 19;27(22):2955-65. 
77 Kamiya Y, Miyazono K, Miyazawa K.
Specificity of the inhibitory effects of Dad on TGF-beta family type I receptors, Thickveins, Saxophone, and Baboon in Drosophila.
FEBS Lett. 2008 Jul 23;582(17):2496-500.  
76 Nagai M, Takahashi N, Miyazawa K, Kawaguchi M, Chijiiwa K, Kataoka H.
Activation of MET receptor tyrosine kinase in ulcer surface epithelial cells undergoing restitution.
Pathol Int. 2008 Jul;58(7):462-4.  
75 Miyazono K, Kamiya Y, Miyazawa K.
SUMO amplifies TGF-beta signalling.
Nat Cell Biol. 2008 Jun;10(6):635-7. [News & Views] 
74 Kawasaki K, Watabe T, Sase H, Hirashima M, Koide H, Morishita Y, Yuki K, Sasaoka T, Suda T, Katsuki M, Miyazono K, Miyazawa K.
Ras signaling directs endothelial specification of VEGFR2+ vascular progenitor cells.
J Cell Biol. 2008 Apr 7;181(1):131-41. 
73 Hayakawa M, Matsushima M, Hagiwara H, Oshima T, Fujino T, Ando K, Kikugawa K, Tanaka H, Miyazawa K, Kitagawa M.
Novel insights into FGD3, a putative GEF for Cdc42, that undergoes SCF(FWD1/beta-TrCP)-mediated proteasomal degradation analogous to that of its homologue FGD1 but regulates cell morphology and motility differently from FGD1.
Genes Cells. 2008 Apr;13(4):329-42. 
72 Nakamura Y, Matsubara D, Goto A, Ota S, Sachiko O, Ishikawa S, Aburatani H, Miyazawa K, Fukayama M, Niki T.
Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines.
Cancer Sci. 2008 Jan;99(1):14-22. 
71 Ehata S, Hanyu A, Hayashi M, Aburatani H, Kato Y, Fujime M, Saitoh M, Miyazawa K, Imamura T, Miyazono K.
Transforming growth factor-beta promotes survival of mammary carcinoma cells through induction of antiapoptotic transcription factor DEC1.
Cancer Res. 2007 Oct 15;67(20):9694-703. 
70 Goto K, Kamiya Y, Imamura T, Miyazono K, Miyazawa K.
Selective inhibitory effects of Smad6 on bone morphogenetic protein type I receptors.
J Biol Chem. 2007 Jul 13;282(28):20603-11.  
 69 Nagano Y, Mavrakis KJ, Lee KL, Fujii T, Koinuma D, Sase H, Yuki K, Isogaya K, Saitoh M, Imamura T, Episkopou V, Miyazono K, Miyazawa K.
Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling.
J Biol Chem. 2007 Jul 13;282(28):20492-501.  
 68 Nakamura Y, Niki T, Goto A, Morikawa T, Miyazawa K, Nakajima J, Fukayama M.
c-Met activation in lung adenocarcinoma tissues: an immunohistochemical analysis.
Cancer Sci. 2007 Jul;98(7):1006-13.
 67 Kobayashi N, Goto K, Horiguchi K, Nagata M, Kawata M, Miyazawa K, Saitoh M, Miyazono K.
c-Ski activates MyoD in the nucleus of myoblastic cells through suppression of histone deacetylases.
Genes Cells. 2007 Mar;12(3):375-85. 
66 Nagata M, Goto K, Ehata S, Kobayashi N, Saitoh M, Miyoshi H, Imamura T, Miyazawa K, Miyazono K.
Nuclear and cytoplasmic c-Ski differently modulate cellular functions.
Genes Cells. 2006 Nov;11(11):1267-80. 
65 Maemura M, Yoshimoto A, Tsukada Y, Morishita Y, Miyazawa K, Tanaka T, Kitamura N.
Inhibitory effect of c-Met mutants on the formation of branching tubules by a porcine aortic endothelial cell line.
Cancer Sci. 2006 Dec;97(12):1343-50.  
64 Kano MR, Morishita Y, Iwata C, Iwasaka S, Watabe T, Ouchi Y, Miyazono K, Miyazawa K.
VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B-PDGFRbeta signaling.
J Cell Sci. 2005 Aug 15;118(Pt 16):3759-68. 
63 Tanaka H, Nagaike K, Takeda N, Itoh H, Kohama K, Fukushima T, Miyata S, Uchiyama S, Uchinokura S, Shimomura T, Miyazawa K, Kitamura N, Yamada G, Kataoka H.
Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is required for branching morphogenesis in the chorioallantoic placenta.
Mol Cell Biol. 2005 Jul;25(13):5687-98. 
62 Suzuki H, Watabe T, Kato M, Miyazawa K, Miyazono K.
Roles of vascular endothelial growth factor receptor 3 signaling in differentiation of mouse embryonic stem cell-derived vascular progenitor cells into endothelial cells.
Blood. 2005 Mar 15;105(6):2372-9.  
61 Kuratomi G, Komuro A, Goto K, Shinozaki M, Miyazawa K, Miyazono K, Imamura T.
NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor.
Biochem J. 2005 Mar 15;386(Pt 3):461-70. 
60 Hayakawa M, Kitagawa H, Miyazawa K, Kitagawa M, Kikugawa K.
The FWD1/beta-TrCP-mediated degradation pathway establishes a 'turning off switch' of a Cdc42 guanine nucleotide exchange factor, FGD1.
Genes Cells. 2005 Mar;10(3):241-51. 
59 Tsukada Y, Tanaka T, Miyazawa K, Kitamura N.
Involvement of down-regulation of Cdk2 activity in hepatocyte growth factor-induced cell cycle arrest at G1 in the human hepatocellular carcinoma cell line HepG2.
J Biochem. 2004 Nov;136(5):701-9. 
58 Itoh H, Naganuma S, Takeda N, Miyata S, Uchinokura S, Fukushima T, Uchiyama S, Tanaka H, Nagaike K, Shimomura T, Miyazawa K, Yamada G, Kitamura N, Koono M, Kataoka H.
Regeneration of injured intestinal mucosa is impaired in hepatocyte growth factor activator-deficient mice.
Gastroenterology. 2004 Nov;127(5):1423-35. 
57 Inoue T, Kataoka H, Goto K, Nagaike K, Igami K, Naka D, Kitamura N, Miyazawa K.
Activation of c-Met (hepatocyte growth factor receptor) in human gastric cancer tissue.
Cancer Sci. 2004 Oct;95(10):803-8. 
56 Komuro A, Imamura T, Saitoh M, Yoshida Y, Yamori T, Miyazono K, Miyazawa K.
Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).
Oncogene. 2004 Sep 9;23(41):6914-23. 
55 Suzuki H, Yagi K, Kondo M, Kato M, Miyazono K, Miyazawa K.
c-Ski inhibits the TGF-beta signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements.
Oncogene. 2004 Jun 24;23(29):5068-76. 
54 Takeda M, Mizuide M, Oka M, Watabe T, Inoue H, Suzuki H, Fujita T, Imamura T, Miyazono K, Miyazawa K.
Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski.
Mol Biol Cell. 2004 Mar;15(3):963-72.  
53 Hori T, Ido A, Uto H, Hasuike S, Moriuchi A, Hayashi K, Nakagawa S, Miyazawa K, Kitamura N, Tsubouchi H.
Activation of hepatocyte growth factor in monkey stomach following gastric mucosal injury.
J Gastroenterol. 2004;39(2):133-9. 
52 Watabe T, Nishihara A, Mishima K, Yamashita J, Shimizu K, Miyazawa K, Nishikawa S, Miyazono K.
TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells.
J Cell Biol. 2003 Dec 22;163(6):1303-11.  
51 Koinuma D, Shinozaki M, Komuro A, Goto K, Saitoh M, Hanyu A, Ebina M, Nukiwa T, Miyazawa K, Imamura T, Miyazono K.
Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7.
EMBO J. 2003 Dec 15;22(24):6458-70. 
50 Kaneko T, Kumasaka T, Ganbe T, Sato T, Miyazawa K, Kitamura N, Tanaka N.
Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain.
J Biol Chem. 2003 Nov 28;278(48):48162-8.  
49 Matsuyama S, Iwadate M, Kondo M, Saitoh M, Hanyu A, Shimizu K, Aburatani H, Mishima HK, Imamura T, Miyazono K, Miyazawa K.
SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells.
Cancer Res. 2003 Nov 15;63(22):7791-8. 
48 Inomata H, Nakamura Y, Hayakawa A, Takata H, Suzuki T, Miyazawa K, Kitamura N.
A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1.
J Biol Chem. 2003 Jun 20;278(25):22946-55.
47 Mizuide M, Hara T, Furuya T, Takeda M, Kusanagi K, Inada Y, Mori M, Imamura T, Miyazawa K, Miyazono K.
Two short segments of Smad3 are important for specific interaction of Smad3 with c-Ski and SnoN.
J Biol Chem. 2003 Jan 3;278(1):531-6.  
46 Miyazawa K, Shinozaki M, Hara T, Furuya T, Miyazono K.
Two major Smad pathways in TGF-beta superfamily signalling.
Genes Cells. 2002 Dec;7(12):1191-204. [Review]  
45 Ota T, Fujii M, Sugizaki T, Ishii M, Miyazawa K, Aburatani H, Miyazono K.
Targets of transcriptional regulation by two distinct type I receptors for transforming growth factor-beta in human umbilical vein endothelial cells.
J Cell Physiol. 2002 Dec;193(3):299-318. 
44 Miyazono K, Miyazawa K.
Id: a target of BMP signaling.
Sci STKE. 2002 Sep 24;2002(151):PE40. [Review] 
43 Kaibori M, Inoue T, Sakakura Y, Oda M, Nagahama T, Kwon AH, Kamiyama Y, Miyazawa K, Okumura T.
Impairment of activation of hepatocyte growth factor precursor into its mature form in rats with liver cirrhosis.
J Surg Res. 2002 Jul;106(1):108-14. 
42 Denda K, Shimomura T, Kawaguchi T, Miyazawa K, Kitamura N.
Functional characterization of Kunitz domains in hepatocyte growth factor activator inhibitor type 1.
J Biol Chem. 2002 Apr 19;277(16):14053-9. 
41 Kaibori M, Inoue T, Oda M, Naka D, Kawaguchi T, Kitamura N, Miyazawa K, Kwon AH, Kamiyama Y, Okumura T.
Exogenously administered HGF activator augments liver regeneration through the production of biologically active HGF.
Biochem Biophys Res Commun. 2002 Jan 11;290(1):475-81. 
40 Kataoka H, Itoh H, Shimomura T, Nuki Y, Naganuma S, Miyazawa K.
Regulation of hepatocyte growth factor (HGF) activation on cell surface: Insights into an emerging class of cell surface protease inhibitors.
Int Arch Biosci. 2001 1036-1042 [Review]
39 Tsukada Y, Miyazawa K, Kitamura N.
High intensity ERK signal mediates hepatocyte growth factor-induced proliferation inhibition of the human hepatocellular carcinoma cell line HepG2.
J Biol Chem. 2001 Nov 2;276(44):40968-76.  
38 Itoh H, Kataoka H, Yamauchi M, Naganuma S, Akiyama Y, Nuki Y, Shimomura T, Miyazawa K, Kitamura N, Koono M.
Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes.
Biochem Biophys Res Commun. 2001 Oct 26;288(2):390-9. 
37 Kataoka H, Shimomura T, Kawaguchi T, Hamasuna R, Itoh H, Kitamura N, Miyazawa K, Koono M.
Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment.
J Biol Chem. 2000 Dec 22;275(51):40453-62. 
36 Kato M, Miyazawa K, Kitamura N.
A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP.
J Biol Chem. 2000 Dec 1;275(48):37481-7. 
35 Itoh H, Hamasuna R, Kataoka H, Yamauchi M, Miyazawa K, Kitamura N, Koono M.
Mouse hepatocyte growth factor activator gene: its expression not only in the liver but also in the gastrointestinal tract.
Biochim Biophys Acta. 2000 Apr 25;1491(1-3):295-302. 
34 Leppテ、nen O, Miyazawa K, Bテ、ckstrテカm G, Pietras K, Sjテカblom T, Heldin CH, Ostman A.
Predimerization of recombinant platelet-derived growth factor receptor extracellular domains increases antagonistic potency.
Biochemistry. 2000 Mar 7;39(9):2370-5. 
33 Shimomura T, Denda K, Kawaguchi T, Matsumoto K, Miyazawa K, Kitamura N.
Multiple sites of proteolytic cleavage to release soluble forms of hepatocyte growth factor activator inhibitor type 1 from a transmembrane form.
J Biochem. 1999 Nov;126(5):821-8. 
32 Kurioka K, Nakagawa K, Denda K, Miyazawa K, Kitamura N.
Molecular cloning and characterization of a novel protein serine/threonine kinase highly expressed in mouse embryo.
Biochim Biophys Acta. 1998 Dec 22;1443(3):275-84. 
31 Miyazawa K, Wang Y, Minoshima S, Shimizu N, Kitamura N.
Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene--phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue-type plasminogen activator.
Eur J Biochem. 1998 Dec 1;258(2):355-61. 
30 Miyazawa K, Bテ、ckstrテカm G, Leppテ、nen O, Persson C, Wernstedt C, Hellman U, Heldin CH, Ostman A.
Role of immunoglobulin-like domains 2-4 of the platelet-derived growth factor alpha-receptor in ligand-receptor complex assembly.
J Biol Chem. 1998 Sep 25;273(39):25495-502. 
29 Omura T, Miyazawa K, Ostman A, Heldin CH.
Identification of a 190-kDa vascular endothelial growth factor 165 cell surface binding protein on a human glioma cell line.
J Biol Chem. 1997 Sep 12;272(37):23317-22.
28 Kawaguchi T, Shimomura T, Denda K, Kitamura A, Kondo J, Kito M, Kagaya S, Qin L, Takata H, MIyazawa K, Kitamura N.
Purification and characterization of a novel protease inhibitor specific to hepatocyte growth factor activator.
Animal Cell Technology: Basic & Applied Aspects, Vol. 8. (Funatsu, K. et al. eds.), pp403-407, Kluwer Academic Publishers. 1997 [Proceedings] 
27 Shimomura T, Denda K, Kitamura A, Kawaguchi T, Kito M, Kondo J, Kagaya S, Qin L, Takata H, Miyazawa K, Kitamura N.
Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor.
J Biol Chem. 1997 Mar 7;272(10):6370-6. 
26 Kinoshita Y, Kishi K, Asahara M, Matasushima Y, Wang HY, Miyazawa K, Kitamura N, Chiba T.
Production and activation of hepatocyte growth factor during the healing of rat gastric ulcers.
Digestion. 1997;58(3):225-31. 
25 Okajima A, Miyazawa K, Naitoh Y, Inoue K, Kitamura N.
Induction of hepatocyte growth factor activator messenger RNA in the liver following tissue injury and acute inflammation.
Hepatology. 1997 Jan;25(1):97-102. 
24 Takeuchi K, Shibamoto S, Hayakawa M, Hori T, Miyazawa K, Kitamura N, Ito F.
Hepatocyte growth factor (HGF)-induced cell migration is negatively modulated by epidermal growth factor through tyrosine phosphorylation of the HGF receptor.
Exp Cell Res. 1996 Mar 15;223(2):420-5
23 Nagamine K, Shibamoto S, Takeuchi K, Miyazawa K, Kitamura N, Chatani Y, Kohno M, Ito F.
Dissociation of c-fos induction and mitogen-activated-protein kinase activation from the hepatocyte-growth-factor-induced motility response in human gastric carcinoma cells.
Eur J Biochem. 1996 Mar 1;236(2):476-81. 
22 Miyazawa K, Shimomura T, Kitamura N.
Activation of hepatocyte growth factor in the injured tissues is mediated by hepatocyte growth factor activator.
J Biol Chem. 1996 Feb 16;271(7):3615-8. 
21 Tang W, Miyazawa K, Kitamura N.
Hepatocyte growth factor remains as an inactive single chain after partial hepatectomy or unilateral nephrectomy.
FEBS Lett. 1995 Apr 3;362(2):220-4. 
20 Shimomura T, Miyazawa K, Komiyama Y, Hiraoka H, Naka D, Morimoto Y, Kitamura N.
Activation of hepatocyte growth factor by two homologous proteases, blood-coagulation factor XIIa and hepatocyte growth factor activator.
Eur J Biochem. 1995 Apr 1;229(1):257-61. 
19 Shibamoto S, Hayakawa M, Takeuchi K, Hori T, Miyazawa K, Kitamura N, Johnson KR, Wheelock MJ, Matsuyoshi N, Takeichi M, Ito F. 
Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes.
J Cell Biol. 1995 Mar;128(5):949-57.
18 Miyazawa K, Shimomura T, Naka D, Kitamura N.
Proteolytic activation of hepatocyte growth factor in response to tissue injury.
J Biol Chem. 1994 Mar 25;269(12):8966-70. 
17 Shibamoto S, Hayakawa M, Takeuchi K, Hori T, Oku N, Miyazawa K, Kitamura N, Takeichi M, Ito F.
Tyrosine phosphorylation of beta-catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cells.
Cell Adhes Commun. 1994 Jan;1(4):295-305. 
16 Hori T, Shibamoto S, Hayakawa M, Takeuchi K, Oku N, Miyazawa K, Kitamura N, Ito F.
Stimulation of prostaglandin production by hepatocyte growth factor in human gastric carcinoma cells.
FEBS Lett. 1993 Nov 22;334(3):331-4. 
15 Shimomura T, Kondo J, Ochiai M, Naka D, Miyazawa K, Morimoto Y, Kitamura N.
Activation of the zymogen of hepatocyte growth factor activator by thrombin.
J Biol Chem. 1993 Oct 25;268(30):22927-32. 
14 Miyazawa K, Shimomura T, Kitamura A, Kondo J, Morimoto Y, Kitamura N.
Molecular cloning and sequence analysis of the cDNA for a human serine protease reponsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII.
J Biol Chem. 1993 May 15;268(14):10024-8. 
13 Okajima A, Miyazawa K, Kitamura N.
Characterization of the promoter region of the rat hepatocyte-growth-factor/scatter-factor gene.
Eur J Biochem. 1993 Apr 1;213(1):113-9. 
12 Kitamura N, Miyazawa K, Uehara Y, Komada M, Okajima A, Okigaki M, Kitamura A.
Gene expression and regulation of HGF-SF.
Hepatocyte Growth Factor-Scatter Factor (HGF-SF) and the c-Met Receptor. (ed. by Goldberg and Rosen), pp49-65, Birkhauser Verkag, Basel, 1993 [Review] 
11

Okigaki M, Komada M, Uehara Y, Miyazawa K, Kitamura N.
Functional characterization of human hepatocyte growth factor mutants obtained by deletion of structural domains.
Biochemistry. 1992 Oct 13;31(40):9555-61.

10 Naka D, Ishii T, Yoshiyama Y, Miyazawa K, Hara H, Hishida T, Kitamura N.
Activation of hepatocyte growth factor by proteolytic conversion of a single chain form to a heterodimer.
J Biol Chem. 1992 Oct 5;267(28):20114-9. 
9 Shibamoto S, Hayakawa M, Hori T, Oku N, Miyazawa K, Kitamura N, Ito F.
Hepatocyte growth factor and transforming growth factor-beta stimulate both cell growth and migration of human gastric adenocarcinoma cells.
Cell Struct Funct. 1992 Jun;17(3):185-90. 
8 Gohda E, Hayashi Y, Miyazawa K, Kitamura N, Yamamoto I.
Hepatocyte growth factor in blood and liver in mice treated with hepatotoxins
Frontiers of mucosal immunology Vol. 1 (Tsuchiya et al. eds.) pp101-104, Elsevior Science Publishers, Amsterdam, 1992 [Proceedings]
7 Komada M, Miyazawa K, Ishii T, Kitamura N.
Characterization of hepatocyte-growth-factor receptors on Meth A cells.
Eur J Biochem. 1992 Mar 1;204(2):857-64. 
6 Miyazawa K, Kitamura A, Kitamura N.
Structural organization and the transcription initiation site of the human hepatocyte growth factor gene.
Biochemistry. 1991 Sep 24;30(38):9170-6. 
5 Miyazawa K, Kitamura A, Naka D, Kitamura N.
An alternatively processed mRNA generated from human hepatocyte growth factor gene.
Eur J Biochem. 1991 Apr 10;197(1):15-22. 
4 Okajima A, Miyazawa K, Kitamura N.
Primary structure of rat hepatocyte growth factor and induction of its mRNA during liver regeneration following hepatic injury.
Eur J Biochem. 1990 Oct 24;193(2):375-81. 
3 Miyazawa K, Inoue K.
Complement activation induced by human C-reactive protein in mildly acidic conditions.
J Immunol. 1990 Jul 15;145(2):650-4. 
2 Miyazawa K, Tsubouchi H, Naka D, Takahashi K, Okigaki M, Arakaki N, Nakayama H, Hirono S, Sakiyama O, Takahashi K, Goda E, Daikuhara Y, Kitamura N.
Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor.
Biochem Biophys Res Commun. 1989 Sep 15;163(2):967-73. 
 1 Miyazawa K, Kiyono S, Inoue K.
Modulation of stimulus-dependent human platelet activation by C-reactive protein modified with active oxygen species.
J Immunol. 1988 Jul 15;141(2):570-4. 

山梨大学医学部・大学院総合研究部・医学域 生化学講座第2教室

生化学講座第2教室Home