17-01  Makino Y, Yoon JH, Bae E, Kato M, Miyazawa K, Ohira T, Ikeda N, Kuroda M, Mamura M.
Repression of Smad3 by Stat3 and c-Ski/SnoN induces gefitinib resistance in lung adenocarcinoma.

Biochem Biophys Res Commun. 2017 Jan 20. pii: S0006-291X(17)30143-2.

16-04  Miyazawa K, Miyazono K.
Regulation of TGF-β Family Signaling by Inhibitory Smads.

Cold Spring Harb Perspect Biol. 2016 Dec 5.

16-03  Hayakawa A, Saitoh M, Miyazawa K.
Dual Roles for Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) in Cancer Progression.

Adv Exp Med Biol. 2016 Jul 12.

16-02  Saitoh M, Endo K, Furuya S, Minami M, Fukasawa A, Imamura T, Miyazawa K
STAT3 integrates cooperative Ras and TGF-β signals that induce Snail expression.

Oncogene. 2016 Feb 25;35(8):1049-57

16-01  Hoshi Y, Endo K, Shirakihara T, Fukagawa A, Miyazawa K, Saitoh M
The potential role of regulator of G-protein signaling 16 in cell motility mediated by δEF1 family proteins.

FEBS Lett. 2016 Jan;590(2):270-8.

15-05  Motizuki M, Saitoh M, Miyazawa K
Maid is a negative regulator of transforming growth factor-β-induced cell migration.

J Biochem. 2015 Nov;158(5):435-44.

15-04  Tsubakihara Y, Hikita A, Yamamoto S, Matsushita S, Matsushita N, Oshima Y,Miyazawa K, Imamura T
Arkadia enhances BMP signaling through ubiquitylation and degradation of Smad6.

J Biochem. 2015 Jul;158(1):61-71.

15-03  Saitoh M
Epithelial-mesenchymal transition is regulated at post-transcriptional levels by transforming growth factor-β signaling during tumor progression.

Cancer Sci. 2015 May;106(5):481-8.

15-02  Kawasaki T, Ishida M, Tada T, Matsuya H, Saitoh M, Sato A, Suzuki M, Sugimoto R, Mue Y, Uesugi N, Ishida K, Ishida K, Ariga H, Ichihara S, Sugai T, Sapino A.
Well-differentiated neuroendocrine tumor of the breast with recurrence due to needle tract seeding.

Virchows Arch. 2015 Apr;466(4):479-81.

15-01  Fukagawa A, Ishii H, Miyazawa K, Saitoh M.
δEF1 associates with DNMT1 and maintains DNA methylation of the E-cadherin promoter in breast cancer cells.

Cancer Med. 2015 Jan;4(1):125-35.

14-03  Ishii H, Saitoh M, Sakamoto K, Kondo T, Katoh R, Tanaka S, Motizuki M, Masuyama K, Miyazawa K.
Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) Suppress Cancer Cell Motility via Different Mechanisms.

J Biol Chem. 2014 Oct 3;289(40):27386-99.

14-02  Isogaya K, Koinuma D, Tsutsumi S, Saito RA, Miyazawa K, Aburatani H, Miyazono K.
A Smad3 and TTF-1/NKX2-1 complex regulates Smad4-independent gene expression.

Cell Res. 2014 Aug;24(8):994-1008.

14-01  Huang M, Xu Q, Mitsui K,Xu Z.
PSK1 regulates expression of SOD1 involved in oxidative stress tolerance in yeast.

FEMS Microbiol Lett. 2014 Jan;350(2):154-60.

13-05  Sakata K, Hara M, Terada T, Watanabe N, Takaya D, Yaguchi S, Matsumoto T, Matsuura T, Shirouzu M, Yokoyama S, Yamaguchi T, Miyazawa K , Aizaki H, Suzuki T, Wakita T, Imoto M, Kojima S.
HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-β type I receptor.

Sci Rep. 2013 Nov 22;3:3243.

13-04  Shirakihara T, Kawasaki T, Fukagawa A, Semba K, Sakai R, Miyazono K, Miyazawa K, Saitoh M.
Identification of integrin α3 as a molecular marker of cells undergoing EMT and of cancer cells with aggressive phenotypes.

Cancer Sci. 2013 Sep;104(9):1189-97.

13-03  Motizuki M, Isogaya K, Miyake K, Ikushima H, Kubota T, Miyazono K, Saitoh M, Miyazawa K.
Oligodendrocyte transcription factor 1 (Olig1) is a Smad cofactor involved in cell motility induced by transforming growth factor-β

J Biol Chem. 2013 Jun 28;288(26):18911-22.

13-02  Saitoh M, Shirakihara T, Fukasawa A, Horiguchi K, Sakamoto K, Sugiya H, Beppu H, Fujita Y, Morita I, Miyazono K, Miyazawa K.
Basolateral BMP Signaling in Polarized Epithelial Cells.

PLoS One. 2013 May 13;8(5):e62659.

13-01  Miyazawa K.
Phosphoinositide 5-phosphatases: How do they affect tumourigenesis?

J Biochem. 2013 Jan;153(1):1-3. [Commentary]

12-05  Miyazawa K.
A negative regulator or just an unconcerned passerby: phosphoinositide 3-kinase signalling in IL-12 production.

J Biochem. 2012 Dec;152(6):497-9. [Commentary]

12-04  Saitoh M, Miyazawa K.
Transcriptional and post-transcriptional regulation in TGF-β-mediated epithelial-mesenchymal transition.

J Biochem. 2012 Jun;151(6): 563-571. [Review]

12-03  Horiguchi K, Sakamoto K, Koinuma D, Semba K, Inoue A, Inoue S, Fujii H, Yamaguchi A, Miyazawa K, Miyazono K, Saitoh M.
TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP.

Oncogene. 2012 Jun 28;31(26):3190-201.

12-02  Miyazawa K.
Phosphorylation in the activation loop as the finishing touch in c-Kit activation.

J Biochem. 2012 May;151(5):457-9. [Commentary]

12-01  Ishii R, Isogaya K, Seto A, Koinuma D, Watanabe Y, Arisaka F, Yaguchi SI, Ikushima H, Dohmae N, Miyazono K, Miyazawa K, Ishitani R, Nureki O.
Structure of a dominant-negative helix-loop-helix transcriptional regulator suggests mechanisms of autoinhibition.
EMBO J. 2012 Mar 27;31(11):2541-52.

11-07  Ikushima H, Todo T, Ino Y, Takahashi M, Saito N, Miyazawa K, Miyazono K.
Glioma-initiating Cells Retain Their Tumorigenicity through Integration of the Sox Axis and Oct4 protein.

J. Biol. Chem. 2011 Dec 2;286(48):41434-41.

11-06  Kawasaki K, and Miyazawa K.
Dissecting the signal transduction pathway that directs endothelial differentiation using embryonic stem cell-derived vascular progenitor cells.

Embryonic Stem Cells -- Differentiation and Pluripotent Alternatives (ed. ByMichael S. Kallos) pp245-266, In Tech, Rijeka (Croatia), 2011 [book chapter]

11-05  Koinuma D, Shinozaki M, Nagano Y, Ikushima H, Horiguchi K, Goto K, Chano T, Saitoh M, Imamura T, Miyazono K, Miyazawa K.
RB1CC1 protein positively regulates transforming growth factor-beta signaling through the modulation of Arkadia E3 ubiquitin ligase activity.

J Biol Chem. 2011 Sep 16;286(37):32502-12.

11-04  Miyazawa K.
Encountering unpredicted off-target effects of pharmacological inhibitors.

J Biochem. 2011 Jul;150(1):1-3. [Commentary]

11-03  Ouyang Y, Xu Q, Mitsui K, Motizuki M, Xu Z.
PSK2 coordinates glucose metabolism and utilization to maintain Ultradian clock-coupled respiratory oscillation in Saccharomyces cerevisiae yeast.

Arch Biochem Biophys. 2011 May 1;509(1):52-8.

11-02  Inoue Y, Iemura SI, Natsume T, Miyazawa K, Imamura T.
Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1.

J Biol Chem. 2011 Feb 25;286(8):6311-20.

11-01 Shirakihara T, Horiguchi K, Miyazawa K, Ehata S, Shibata T, Morita I, Miyazono K, Saitoh M.
TGF-beta regulates FGF receptor isoform switching and epithelial-mesenchymal transition.
EMBO J. 2011 Feb 16;30(4):783-95.

10-05  Mizutani A, Saitoh M, Imamura T, Miyazawa K, Miyazono K.
Arkadia complexes with clathrin adaptor AP2 and regulates EGF signalling.
J Biochem. 2010 Dec;148(6):733-41.

10-04  Kamiya Y, Miyazono K, Miyazawa K.
Smad7 inhibits transforming growth factor-beta family type i receptors through two distinct modes of interaction.

J Biol Chem. 2010 Oct 1;285(40):30804-13.

10-03 Nagata M, Nagata S, Yuki K, Isogaya K, Saitoh M, Miyazono K, Miyazawa K.
Identification of a phosphorylation site in c-Ski as serine 515.
J Biochem. 2010 Oct;148(4):423-7.

10-02 Miyazawa K.
Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor.
FEBS J. 2010 May;277(10):2208-14.

10-01  Nagano Y, Koinuma D, Miyazawa K, Miyazono K.
Context-dependent regulation of the expression of c-Ski protein by Arkadia in human cancer cells.

J Biochem. 2010 Apr;147(4):545-54.

 09-03 Hanyu A, Kojima K, Hatake K, Nomura K, Murayama H, Ishikawa Y, Miyata S, Ushijima M, Matsuura M, Ogata E, Miyazawa K, Imamura T.
Functional in vivo optical imaging of tumor angiogenesis, growth and metastasis prevented by administration of anti-human VEGF antibody in xenograft model of human fibrosarcoma HT1080 cells.
Cancer Sci. 2009 Nov;100(11):2085-92.

 09-02 Motizuki M. and Xu Z.
Importance of polarisome proteins in reorganization of actin cytoskelton at low pH in Sacchromyces cerevisiae.
J Biochem. 2009 Nov;146(5):705-12.

 09-01 Ouyang Y, Xu Q, Mitsui K, Motizuki M, Xu Z.
Human trehalase is a stress responsive protein in Saccharomyces cerevisiae.
Biochem Biophys Res Commun. 2009 Feb 6;379(2):621-5.

山梨大学医学部・大学院総合研究部・医学域 生化学講座第2教室