Research Achievement

Research Achievement in 2020

English Medical Articles

  1. RIP3 as a diagnostic and severity marker for Stevens-Johnson syndrome and toxic epidermal necrolysis. Hasegawa A, Shinkuma S, Hayashi R, Hama N, Watanabe H, Kinoshita M, Ogawa Y, Abe R.
    Journal of Allergy and Clinical Immunology-In Practice. 8(5):1768-1771 2020
  2. Japanese Dermatological Association Guidelines: Outlines of guidelines for cutaneous melanoma 2019. Nakamura Y, Asai J, Igaki H, Inozume T, Namikawa K, Hayashi A, et al.
    JOURNAL OF DERMATOLOGY 47(2):89-103 2020

Research Achievement in 2019

English Medical Articles

  1. Downregulation of integrin-αvβ6 on keratinocytes in the scar of lichen planopilaris and folliculitis decalvans: Relevance for the disappearance of epidermal Langerhans cells. Kinoshita M, Ogawa Y, Yamamoto S, Simada S, Harada K, Kawamura T. J Dermatol. 46(7) 2019
  2. Galectin-7 as a potential biomarker of Stevens-Johnson syndrome/toxic epidermal necrolysis: identification by targeted proteomics using causative drug-exposed peripheral blood cells. Hama N, Nishimura K, Hasegawa A, Yuki A, Kume H, Adachi J, Kinoshita M, Ogawa Y, Nakajima S, Nomura T, Watanabe H, Mizukawa Y, Tomonaga T, Shimizu H, Abe R. J Allergy Clin Immunol Pract. 5 (19) 2019
  3. Biotin Is Required for the Zinc Homeostasis in the Skin. Ogawa Y, Kinoshita M, Sato T, Shimada S, Kawamura T. Nutrients. 24;11(4) 2019
  4. Zinc transporters in the epidermis. Ogawa Y, Kinoshita M, Shimada S, Kambe T, Kawamura T. J Dermatol. 5(30) 2019
  5. Zinc deficiency exacerbates pressure ulcers by increasing oxidative stress and ATP in the skin. Nakamura H, Sekiguchi A, Ogawa Y, Kawamura T, Akai R, Iwawaki T, Makiguchi T, Yokoo S, Ishikawa O, Motegi SI. JOURNAL OF DERMATOLOGICAL SCIENCE
    95/ 2, 62-69 2019
  6. Presence of a Family History and Excessive Pressure on the First Toe Pad During Walking in Female Subjects With Pincer Nails. Makino K, Ogawa Y, Kanagawa T, Matsuzawa M, Yamamoto S, Yamada K, Shimada S, Kawamura T, Terada H. Japanese journal of dermatology
    46/ 7, 631-633 2019
  7. Acute Generalized Exanthematous Pustulosis Associated With Anti-Interferon-γ Neutralizing Autoantibody-Positive Disseminated Nontuberculous Mycobacterial Infection. Ogawa Y, Hasebe R, Ohnuma T, Sano S, Mitsui H, Shimada S, Ishihara H, Sakagami T, Kawamura T. European journal of dermatology
    29/ 3, 339-341 2019
  8. Epidermal keratinocytes need zinc. Y.Ogawa BRITISH JOURNAL OF DERMATOLOGY
    180/ 4, 707-709 2019
  9. Autoantibodies Detected in Patients With Vitiligo Vulgaris but Not in Those With Rhododendrol-Induced Leukoderma Arase N, Tanemura A, Jin H, Nishioka M, Aoyama Y, Oiso N, Matsunaga K, Suzuki T, Nishigori C, Kawamura T, Shimizu T, Ito A, Fukai K, Abe Y, Yang L, Tsuruta D, Takeoka K, Iwatani Y, Hidaka Y, Nishida M, Yamauchi-Takihara K, Arase H, Fujimoto M, Katayama I. Journal of dermatological science
    95/ 2, 80-83 2019
  10. eccrine angiomatous hamartoma. Mitsui H, Sano S, Shimada S, Kawamura T. Practical Dermatology 29/ 1, 93-94 2019
  11. Coexistence of anti-topoisomerase I and anti-RNA polymerase III antibody in a patient with overlap syndrome. Shimizu T, Ogawa Y, Tomita O, Asano Y, Shimada S, Kawamura T. EUROPEAN JOURNAL OF DERMATOLOGY 29/ 1, 93-94 2019
  12. Analysis of the tumor reactivity of tumor-infiltrating lymphocytes in a metastatic melanoma lesion that lost MHC class I expression after anti-PD-1 therapy. Inozume T, Yaguchi T, Ariyasu R, Togashi Y, Ohnuma T, Honobe A, Nishikawa H, Kawakami Y, Kawamura T. JOURNAL OF INVESTIGATIVE DERMATOLOGY 139/ 7, 1490-1496 2019
  13. Cytotoxic T-lymphocyte-associated protein 4 expressed by melanoma cells does not affect melanoma-specific cytotoxic T lymphocytes in the effector phase. JOURNAL OF DERMATOLOGY. Inozume T, Hanada KI, Takeda K, Maeda T, Harada K, Kawamura T.46/ 1, 52-56 2019

Research Achievement in 2018

English Medical Articles

  1. Differential Day-Night Outcome to HSV-2 Cutaneous Infection. Matsuzawa T, Nakamura Y, Ogawa Y, Ishimaru K, Goshima F, Shimada S, Nakao A, Kawamura T. J Invest Dermatol. 138(1):233-236 2018.
  2. Zinc and Skin Disorders. Ogawa Y, Kinoshita M, Shimada S, Kawamura T. Nutrients. 11;10(2) :E199 2018.
  3. DLX3-dependent STAT3 signaling in keratinocytes regulates skin immune homeostasis. Bhattacharya S, Kim JC, Ogawa Y, Nakato G, Nagle V, Brooks SR, Udey MC, Morasso MI. J Invest Dermatol. 138(5):1052-1061 2018
  4. Zinc in Keratinocytes and Langerhans Cells: Relevance to the Epidermal Homeostasis. Ogawa Y, Kinoshita M, Shimada S, Kawamura T. J Immunol Res. 11(9) 2018
  5. Impetigo herpetiformis with IL-36RN mutation successfully treated with secukinumab. Kinoshita M, Ogawa Y, Takeichi T, Okamoto T, Osada A, Shimada S, Sugiura K, Akiyama M, Kawamura T, Tsukamoto K. Eur J Dermatol. 1;28(3):381-382 2018
  6. Purinergic Molecules in the Epidermis. Ogawa Y, Kinoshita M, Mizumura N, Miyazaki S, Aoki R, Momosawa A, Shimada S, Kambe T, Kawamura T. J Invest Dermatol. 138(11):2486-2488 2018
  7. Deficiency of the interleukin-36 receptor antagonist dramatically improved by secukinumab. Kinoshita M, Okamoto T, Sano S, Mitsui H, Takeichi T, Sugiura K, Akiyama M, Shimada S, Kawamura T. J Dermatol. 45(10):280-281 2018
  8. Dyschromatosis symmetrica hereditaria may be successfully controlled by topical sunscreen. Kono M, Okamoto T, Takeichi T, Muro Y, Akiyama M. Eur J Dermatol. 2018 Dec 1;28(6):840-841.
  9. Novel immune signatures associated with dysplastic naevi and primary cutaneous melanoma in human skin. Yan BY, Garcet S, Gulati N, Mitsui H, et al
    EXPERIMENTAL DERMATOLOGY 28(1):35-44 2018

Research Achievement in 2017

English Medical Articles

  1. Increased Soluble CD226 in Sera of Patients with Cutaneous T-Cell Lymphoma Mediates Cytotoxic Activity against Tumor Cells via CD155. Takahashi N, Sugaya M, Suga H, Oka T, Kawaguchi M, Miyagaki T, Fujita H, Inozume T, Sato S. J Invest Dermatol. 137(8):1766-1773 2017.
  2. Phase 1b study of pembrolizumab (MK-3475; anti-PD-1 monoclonal antibody) in Japanese patients with advanced melanoma (KEYNOTE-041). Yamazaki N, Takenouchi T, Fujimoto M, Ihn H, Uchi H, Inozume T, Kiyohara Y, Uhara H, Nakagawa K, Furukawa H, Wada H, Noguchi K, Shimamoto T, Yokota K. Cancer Chemother Pharmacol. 79(4):651-660 2017.
  3. Efficacy of topical tacrolimus for treating Kyrle's disease. Kinoshita M, Ogawa Y, Kawamura T, Shimada S. J Dermatol. 44(5):e81-e82 2017.
  4. Immunological function of Langerhans cells in HIV infection. Matsuzawa T, Ogawa Y, Moriishi K, Shimada S, Kawamura T. J Dermatol Sci. 87(2):159-167 2017.
  5. Case of anal adenocarcinoma in situ with pagetoid spread but without macroscopic abnormality in anal mucosa. Shimizu T, Inozume T, Takaki M, Ohnuma T, Sano S, Kawamura T, Shimada S. J Dermatol. 44(9):1076-1077 2017.

Research Achievement in 2016

English Medical Articles

  1. Takaki M, Inozume T, Sano S, Mitsui H, Kawamura T, Shimada S. Case of giant cell arteritis as a manifestation of immunoglobulin G4-related disease. J Dermatol. 2016 Oct;43(10):1248-1249
  2. Inozume T, Yaguchi T, Furuta J, Harada K, Kawakami Y, Shimada S. Melanoma Cells Control Antimelanoma CTL Responses via Interaction between TIGIT and CD155 in the Effector Phase. J Invest Dermatol. 2016 Jan;136(1):255-63.
  3. Matsuzawa M, Inozume T, Sano S, Ando N, Onuma T, Harada K, Kawamura T, Shimada S. A case of recurrent squamous cell carcinoma of the vulva successfully treated by combination therapy with cetuximab and paclitaxel. Br J Dermatol. 2016 Mar;174(3):677-8.
  4. Aoki R, Kawamura T, Goshima F, Ogawa Y, Nakae S, Moriishi K, Nakao A, Shimada S. The Alarmin IL-33 Derived from HSV-2-Infected Keratinocytes Triggers Mast Cell-Mediated Antiviral Innate Immunity. J Invest Dermatol. 2016 Jun;136(6):1290-1292
  5. Kinoshita M, Ogawa Y, Kawamura T, Kirito K, Shimada S. Case of disseminated molluscum contagiosum caused by ruxolitinib, a Janus kinase 1 and 2 inhibitor. J Dermatol. 2016 Nov;43(11):1387-1388
  6. Ogawa, Y.*, Kawamura, T., Shimada, S. Zinc and skin biology. Arch Biochem Biophys. 2016 611:113-119
  7. Kinoshita, M., Ogawa, Y.*, Kawamura, T, Shimada, S. Efficacy of topical tacrolimus for treating Kyrle's disease. J Dermatol. 2016 in press

Research Achievement in 2015

English Medical Articles

  1. Ando N, Nakamura Y, Ishimaru K, Ogawa H, Okumura K, Shimada S, Nakao A. Allergen-specific basophil reactivity exhibits daily variations in seasonal allergic rhinitis. Allergy. 70(3):319-22.
  2. Matsuzawa M, Harada K, Hosomura N, Amemiya H, Ando N, Inozume T, Kawamura T, Shibagaki N, Shimada S. Non-occlusive mesenteric ischemia after chemotherapy for metastatic melanoma. The Journal of Dermatology. 42(1):105-106.
  3. Matsuzawa T, Kawamura T, Ogawa Y, Maeda K, Nakata H, Moriishi K, Koyanagi Y, Gatanaga H, Shimada S, Mitsuya H. EFdA, a reverse transcriptase inhibitor, potently blocks HIV-1 ex vivo infection of Langerhans cells within epithelium. Journal of Investigative Dermatology. 134(4):1158-1161.
  4. Ahmed Z, Kawamura T, Shinji Shimada, Piguet V. The role of human dendritic cells in HIV-1 infection, co-Infection and as targets for HIV-1 vaccine development.
    Journal of Investigative Dermatology. 135:1225-1233
  5. Harada K, Yamaguchi M, Kawamura T, Shibagaki N, Shimada S. A case of 4-related syndrome presenting with a fibroma molle-like nodule　International Journal Dermatology. 54:163-165
  6. Matsuzawa M, Inozume T, Sano S, Ando N, Onuma T, Harada K, Kawamura T, Shimada S. A case of recurrent squamous cell carcinoma of the vulva successfully treated by combination therapy with cetuximab and paclitaxel.
    British Journal of Dermatology. 174(3):677-678
  7. Matsuzawa T, Inozume T, Takaki M, Harada K, Kawamura T, Shibagaki N, Shimada S. Case of folliculotropic mycosis fungoides with prominent loss of T-cell antigens CD7 and CD26 in blood T cells. J Dermatol. 2015 Jan;42(1):108-109.
  8. Ando N, Nakamura Y, Aoki R, Ishimaru K, Ogawa H, Okumura K, Shibata S, Shimada S, Nakao A. Circadian Gene Clock Regulates Psoriasis-Like Skin Infammation in Mice. Journal of Investigative Dermatology. 135(12):3001-3008
  9. Inozume T. Yaguchi T. Furuta J. Harada K. Kawakami Y. Shimada S. Melanoma Cell Control Anti-Melanoma CTL Responses via Interaction between TIGIT and CD155 in the Effector Phase. The Journal of Investigative Dermatology. 136(1):255-263
  10. Ando N. Nakamura Y. Ishimaru K. Ogawa H. Okumura K. Shimada S. Nakao A.
    Allergen-specific basophil reactivity exhibits daily variations in seasonal allergic rhinitis. Allergy. 70(3):319-322

Research Achievement in 2014

English Medical Articles

  1. Mitsui H, Suarez-Farinas M, Gulati N, Shah KR, Cannizzaro MV, Coats I, Felsen D, Krueger JG, Carucci JA. Gene expression profiling of the leading edge of cutaneous squamous cell carcinoma (SCC): IL-24 driven MMP-7. J Invest Dermatol, 2014 May; 134 (5), 1418-1427
  2. Chiricozzi A, Nograles KE, Johnson-Huang LM, Fuentes-Duculan J, Cardinale I, Bonifacio KM, Gulati N, Mitsui H, Guttman-Yassky E, Suarez-Farinas M, Krueger JG. IL-17 Induces an Expanded Range of Downstream Genes in Reconstituted Human Epidermis Model. PLoS ONE, 2014 Feb; 9 (2), e90284
  3. Furuta J, Inozume T, Harada K, Shimada S. CD271 on Melanoma Cell Is an IFN-γ-Inducible Immunosuppressive Factor that Mediates Downregulation of Melanoma Antigens. J Invest Dermatol. 2014 134:1369-1377
  4. Matsuzawa T, Kawamura T, Ogawa Y, Maeda K, Nakata H, Moriishi K, Koyanagi Y, Gatanaga H, Shimada S, Mitsuya H. EFdA, a Reverse Transcriptase Inhibitor, Potently Blocks HIV-1 Ex Vivo Infection of Langerhans Cells within Epithelium. J Invest Dermatol 2014 134:1158-1161
  5. Inozume T, Nakazawa R, Tanaka K, Harada K, Kawamura T, Shibagaki N, Shimada S. A case of oral mucosal fixed eruption caused by methacrylate. Contact Dermatitis, in press
  6. Ito T, Furukawa F, Iwatsuki K, Matsue H, Shimada S, Takigawa M, Tokura Y. Efficacious treatment of psoriasis with low-dose and intermittent cyclosporin microemulsion therapy. J Dermatol. 2014 Mar 15. 1346-8138.12455. [Epub ahead of print]
  7. Hamada T, Nakamura S, Ko YH, Yoshino T, Ohshima K, Matsuzawa T, Miura K, Takahashi T, Nomura H, Hoshino T, Suzuki D, Shimada S, Iwatsuki K. Epstein-Barr virus-associated T/natural killer-cell lymphomas in the elderly: The first consensus meeting in Kofu 2013. J Dermatol 2014 41:40-42
  8. Inozume T, Nakazawa R, Tanaka K, Harada K, Kawamura T, Shibagaki N, Shimada S. Case of primary cutaneous peripheral T-cell lymphoma, not otherwise specified, with characteristics of follicular helper T cells. The Journal of Dermatology. 41(6):　in press.2014
  9. Shimizu T, Harada K, Akazawa S, Yamaguch M, Inozume　T, Kawamura T, Shibagaki N, Momosawa A, Shimada S. Identification of the cause of severe skin infection by Fournier transform infrared spectroscopy: a case of Fournier's gangrene caused by fish bone. The　Journal of Dermatology. 41(6):547-50.
  10. Takaki M, Inozume T, Matsuzawa T, Ando N, Yamaguchi M, Harada K, Kawamura T, Shibagaki N, Shimada S.Case of primary cutaneous peripheral T-cell lymphoma, not otherwise specified, with characteristics of follicular helper T cells. The Journal of Dermatology. 41(6):529-532
  11. Yamamoto S. Harada K. Ando N. Kawamura T. Shibagaki N. Tanaka M. Shimada S. Nodular melanoma on the hyponychium : Clinical and dermoscopic features. The Journal of Dermatology. 41(3):277-278
  12. Ogawa　Y, Kawamura　T, Matsuzawa　T, Aoki　R, Shimada　S. Recruitment of plasmacytoid dendritic cells to skin regulates treatment responsiveness of actinic keratosis to imiquimod. The Journal of Dermatology Science. 76(1):67-69
  13. Kawamura T, Ogawa Y, Aoki R, Shimada S. Innate and intrinsic antiviral immunity in skin. The Journal of Dermatology Science. 75(3):159-166
  14. Alam　MS, Gaida　MM, Ogawa Y, Kolios　AG, Lasitschka　F, Ashwell　JD. Counter-regulation of T cell effector function by differentially activated p38. The Journal of Experimental Medicine. 211(6):1257-1270
  15. Matsuzawa T, Inozume T, Takaki M, Harada K, Kawamura T, Shibagaki N, Shimada S. Case of folliculotropic mycosis fungoides with prominent loss of T-cell antigens CD7 and CD26 in blood T cells. The Journal of Dermatology. 42(1):108-109
  16. Kawamura T, Ogawa Y, Aoki R, Shimada S .Innate and intrinsic antiviral immunity in skin. The Journal of Dermatology Science. 75(3):159-66

Research Achievement in 2013

English Medical Articles

  1. Hanawa F, Inozume T, Harada K, Andou N, Kawamura T, Shibagaki N, Shimada S  A case of dermatomyositis accompanied by spontaneous intramuscular hemorrhage despite normal coagulability. Rheumatol International 2013 33:2949-2950
  2. Matsuzawa T, Kawamura T, Ogawa Y, Takahashi M, Aoki R, Moriishi K, Koyanagi Y, Gatanaga H, Blauvelt A, Shimada S  Oral administration of the CCR5 inhibitor, maraviroc, blocks HIV ex vivo infection of Langerhans cells within the epithelium. J Invest Dermatol. 2013 133:2803-2805
  3. Aoki R, Kawamura T, Goshima F, Ogawa Y, Nakae S, Nakao A, Moriishi K, Nishiyama Y, Shimada S  Mast cells play a key role in host defense against herpes simplex virus infection through TNF-α and IL-6 production. J Invest Dermatol. 2013 133:2170-2179
  4. Harada K, Inozume T, Kawamura T, Shibagaki N, Kinoshita T, Deguchi N, Shimada S  Two cases of autosomal recessive woolly hair with LIPH gene mutations. Int J Dermatol. 2013 52:572-574
  5. Geng S, Matsushima H, Okamoto T, Yao Y, Lu R, Page K, Blumenthal RM, Ward NL, Miyazaki T, Takashima A  Emergence, origin, and function of neutrophil-dendritic cell hybrids in experimentally induced inflammatory lesions in mice. Blood. 2013 121:1690-1700
  6. Matsushima H, Geng S, Lu R, Okamoto T, Yao Y, Mayuzumi N, Kotol PF, Chojnacki BJ, Miyazaki T, Gallo RL, Takashima A  Neutrophil differentiation into a unique hybrid population exhibiting dual phenotype and functionality of neutrophils and dendritic cells. Blood. 2013 121:1677-1689
  7. Ogawa Y, Kawamura T, Matsuzawa T, Aoki R, Gee P, Yamashita A, Moriishi K, Yamasaki K, Koyanagi Y, Blauvelt A, Shimada SAntimicrobial peptide LL-37 produced by HSV-2-infected keratinocytes enhances HIV infection of Langerhans cells. Cell Host Microbe. 2013 13:77-86
  8. Iwamoto T, Ikeda K, Hosokawa J, Yamagata M, Tanaka S, Norimoto A, Sanayama Y, Nakagomi D, Takahashi K, Hirose K, Sugiyama T, Sueishi M, Nakajima H. Ultrasonographic assessment predicts relapse after discontinuation of biological agents in patients with rheumatoid arthritis in clinical remission. Arthritis Care Res (Hoboken). 2014 Feb 10. doi: 10.1002/acr.22303. [Epub ahead of print]
  9. Nakagomi D, Ikeda K, Okubo A, Iwamoto T, Sanayama Y, Takahashi K, Yamagata M, Takatori H, Suzuki K, Takabayashi K, Nakajima H. Ultrasound can improve the accuracy of the 2010 ACR/EULAR classification criteria for rheumatoid arthritis to predict methotrexate requirement. Arthritis Rheum. 2013;65(4):890-8.
  10. Nakagomi D, Suzuki K, Hosokawa J, Kobayashi Y, Suto A, Takatori H, Watanabe N, Matsue H, Murphy TL, Murphy KM, Shimada S, Nakajima H. Therapeutic Potential of B and T Lymphocyte Attenuator Expressed on CD8(+) T Cells for Contact Hypersensitivity. J Invest Dermatol. 2013;133(3):702-11.
  11. Nakagomi D, Ikeda K, Kawashima H, Kobayashi Y, Suto A, Nakajima H. Bucillamine-induced yellow nail in Japanese patients with rheumatoid arthritis: two case reports and a review of 36 reported cases. Rheumatol Int. 2013 Mar;33(3):793-7.
  12. Ikeda K, Sanayama Y, Makita S, Hosokawa J, Yamagata M, Nakagomi D, Takabayashi K, Nakajima H. Efficacy of Abatacept for Arthritis in Patients with an Overlap Syndrome between Rheumatoid Arthritis and Systemic Lupus Erythematosus. Clin Dev Immunol. 2013;2013:697525. doi: 10.1155/2013/697525. Epub 2013 Nov 14.
  13. Ikeda K, Nakagomi D, Sanayama Y, Yamagata M, Okubo A, Iwamoto T, Kawashima H, Takahashi K, Nakajima H. Correlation of radiographic progression with the cumulative activity of synovitis estimated by power Doppler ultrasound in rheumatoid arthritis: difference between patients treated with methotrexate and those treated with biological agents.J Rheumatol. 2013 Dec;40(12):1967-76.
  14. Ikeda K, Seto Y, Ohno S, Sakamoto F, Henmi M, Fukae J, Narita A, Nakagomi D, Nakajima H, Tanimura K, Koike T. Analysis of the factors influencing the measurement of synovial power Doppler signals with semi-quantitative and quantitative measures - a pilot multicenter exercise in Japan. Mod Rheumatol. 2013 Nov 5
  15. Tanaka S, Suto A, Ikeda K, Iwamoto T, Sanayama Y, Nakagomi D, Suzuki K, Nakajima H. Alteration of circulating microRNAs in SSc: microRNA-30b regulates the expression of PDGF receptor β. Rheumatology (Oxford). 2013 Nov;52(11):1963-72.
  16. Tanaka S, Ikeda K, Uchiyama K, Iwamoto T, Sanayama Y, Okubo A, Nakagomi D, Takahashi K, Yokota M, Suto A, Suzuki K, Nakajima H. [18F] FDG uptake in proximal muscles assessed by PET/CT reflects both global and local muscular inflammation and provides useful information in the management of patients with polymyositis/dermatomyositis. Rheumatology (Oxford). 2013 Jul;52(7):1271-8.
  17. Hosokawa J, Suzuki K, Nakagomi D, Tamachi T, Takatori H, Suto A, Nakajima H. Role of calcium ionophore A23187-induced activation of IkappaB kinase 2 in mast cells.Int Arch Allergy Immunol. 2013 161 Suppl 2:37-43.
  18. Ning H, Mitsui H, Wang CQ, Suarez-Farinas M, Gonzalez J, Shah KR, Chen J, Coats I, Felsen D, Carucci JA, Krueger JG　 Identification of anaplastic lymphoma kinase as a potential therapeutic target in Basal Cell Carcinoma. Oncotarget.2013 4:2237-48
  19. Belkin DA, Chen J, Mo JL, Rosoff JS, Goldenberg S, Poppas DP, Krueger JG, Herschman M, Mitsui H, Felsen D, Carucci JA　An animal explant model for the study of human cutaneous squamous cell carcinoma. PLoS One. 2013 8:e76156
  20. Wang CQ, Akalu YT, Suarez-Farinas M, Gonzalez J, Mitsui H, Lowes MA, Orlow SJ, Manga P, Krueger JG　IL-17 and TNF synergistically modulate cytokine expression while suppressing melanogenesis: potential relevance to psoriasis. J Invest Dermatol. 2013 133:2741-52
  21. Gulati N, Krueger JG, Suarez-Farinas M, Mitsui H　Creation of differentiation-specific genomic maps of human epidermis through laser capture microdissection. J Invest Dermatol. 2013 133:2640-2
  22. Zhang S, Fujita H, Mitsui H, Yanofsky VR, Fuentes-Duculan J, Pettersen JS, Suarez-Farinas M, Gonzalez J, Wang CQ, Krueger JG, Felsen D, Carucci JA　Increased Tc22 and Treg/CD8 ratio contribute to aggressive growth of transplant associated squamous cell carcinoma. PLoS One. 2013 7:e62154.
  23. Yanofsky VR, Mitsui H, Felsen D, Carucci JA　Understanding dendritic cells and their role in cutaneous carcinoma and cancer immunotherapy. Clin Dev　Immunol.2013;2013:624123.
  24. Belkin DA, Mitsui H, Wang CQ, Gonzalez J, Zhang S, Shah KR, Coats I, Suarez-Farinas M, Krueger JG, Felsen D, Carucci JA　CD200 upregulation in vascular endothelium surrounding cutaneous squamous cell carcinoma.JAMA Dermatol. 2013 149:178-86
  25. Belkin DA, Mitsui H, Wang CQ, Gonzalez J, Zhang S, Shah KR, Coats I, Suarez-Farinas M, Krueger JG, Felsen D, and Carucci JA. CD200 upregulation in vascular endothelium surrounding cutaneous squamous cell carcinoma. JAMA Dermatol. 2013 Feb; 149 (2), 178-186
  26. Yanofsky VR, Mitsui H, Felsen D, Carucci JA. Understanding Dendritic Cells and their Role in Cutaneous Carcinoma and Cancer Immunotherapy. 2013, Clin Dev Immunol, 2103, Article ID 624123
  27. Zhang S, Fujita H, Mitsui H, Fuentes-Duculan J, Yanofsky VR, Pettersen J, Suarez-Farinas M, Gonzalez J, Wang CQ, Krueger JG, Felsen D, Carucci JA. Increased Tc22 and T-reg/Tc ratio accelerate progression of transplant-associated SCC. PLoS ONE, 2013 May; 8 (5), e62154
  28. Gulati N, Krueger JG, Suarez-Farinas M, Mitsui H. Creation of differentiation-specific genomic maps of human epidermis through laser capture microdissection. J Invest Dermatol, 2013 Nov; 133 (11), 2640-2642
  29. Wang CQ, Akalu YT, Suarez-Farinas M, Gonzalez J, Mitsui H, Lowes MA, Orlow SJ, Manga P, Krueger JG. IL-17 and TNF synergistically modulate cytokine expression while suppressing melanogenesis: potential relevance to psoriasis. J Invest Dermatol, 2013 Dec; 133 (12), 2741-2752
  30. Belkin DA, Chen J, Mo JL, Rosoff J, Goldenberg S, Poppas D, Krueger JG, Herschman M, Mitsui H, Felsen D, and Carucci JA. An animal explant model for the study of human cutaneous squamous cell carcinoma. PLoS ONE, 2013 Oct; 8 (10), e76156
  31. Ning H, Mitsui H, Wang CQ, Suarez-Farinas M, Gonzalez J, Shah KR, Chen J, Israel C, Felsen D, Carucci JA, Krueger JG. Identification of anaplastic lymphoma kinase as a potential therapeutic target in Basal Cell Carcinoma. Oncotarget, 2013 Dec; 4 (12), 2237-2248
  32. Harada K, Yamaguchi M, Watanabe S, Shimada S  Onychogryphosis by an elastic wire. J Dermatol. 2013 40:1055-1056
  33. Geng S, Matsushima H, Okamoto T, Yao Y, Lu R, Takashima A  Reciprocal Regulation of Development of Neutrophil-Dendritic Cell Hybrids in Mice by IL-4 and Interferon-Gamma. PLoS One. 2013 8:1371

Research Achievement in 2012

English Medical Articles

  1. Inozume T, Ando N, Sano S, Harada K, Kawamura T, Shibagaki N, Shimada S. Case of rheumatoid papules: is this a link between vasculitis and rheumatoid nodules? J Dermatol. 2012 Dec;39(12):1091-2.
  2. Ogawa Y, Aoki R, Harada K, Matsuzawa T, Inozume T, Shibagaki N, Kawamura T, Shimada S. Neutrophilic panniculitis with non-caseating granulomas in a Crohn's disease patient. Eur J Dermatol. 2012 May-Jun;22(3):404-5.
  3. Inozume T, Kawasaki T, Harada K, Tanaka K, Kawamura T, Shibagaki N, Katoh R, Shimada S. A case of endocrine mucin-producing sweat gland carcinoma. Pathol Int. 2012 May;62(5):344-6.
  4. Harada K, Yamaguchi M, Miyajima S, Kawamura T, Shibagaki S, Shimada S. Gutter method: noninvasive management of ingrown nails caused by epidermal growth factor inhibitor treatment. Clin Exp Dermatol. 2012 Aug;37(6):703-4.
  5. Ogawa Y, Aoki R, Harada K, Matsuzawa T, Inozume T, Shibagaki N, Kawamura T, Shimada S. Neutrophilic panniculitis with non-caseating granulomas in a Crohn's disease patient. Eur J Dermatol. 2012 May-Jun;22(3):404-5.
  6. Harada K, Morohoshi T, Ikeda T, Shimada S. A patient with pseudochromhidrosis presenting with pink nails. J Am Acad Dermatol. 2012 Aug;67(2):e74-5.
  7. Hanawa F, Harada K, Andou N, Kawamura T, Shibagaki N, Fukuda S, Hashimoto T, Shimada S. Case of mucous membrane pemphigoid characterized by circulating immunoglobulin A and immunoglobulin G autoantibodies to the gamma-2 subunit of laminin-332. J Dermatol. 2012 Nov;39(11):962-3.
  8. Kawamura T, Ogawa Y, Nakamura Y, Nakamizo S, Ohta Y, Nakano H, Kabashima K, Katayama I, Koizumi S, Kodama T, Nakao A, Shimada S. Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency. J Clin Invest. 2012 Feb 1;122(2):722-32.
  9. Sakaizawa K, Goto Y, Kiniwa Y, Uchiyama A, Harada K, Shimada S, Saida T, Ferrone S, Takata M, Uhara H, Okuyama R. Mutation analysis of BRAF and KIT in circulating melanoma cells at the single cell level. Br J Cancer. 2012 Feb 28;106(5):939-46.
  10. Tanaka K, Ogawa Y, Shimada S. Drug eruption caused by sitagliptin, a dipeptidyl peptidase-IV inhibitor. J Dermatol. 2012 Aug;39(8):726-8.
  11. Nakagomi D, Harada K, Shimada S. Case of tubular apocrine adenoma with follicular differentiation located on the trunk. J Dermatol. 2012 Jul;39(7):653-4.
  12. Nakagomi D, Suzuki K, Nakajima H. Critical roles of I?B kinase subunits in mast cell degranulation. Int Arch Allergy Immunol. 2012;158 Suppl 1:92-5.
  13. Kennedy-Crispin M, Billick E, Mitsui H, Gulati N, Fujita H, Gilleaudeau P, Sullivan-Whalen M, Johnson-Huang LM, Suarez-Farinas M, Krueger JG. Human keratinocytes have a response to injury that upregulates CCL20 and other genes linking innate and adaptive immunity. J Invest Dermatol. 2012 Jan; 132 (1) 105-113
  14. Fujita H, Suarez-Farinas M, Mitsui H, Gonzalez J, Bluth MJ, Zhang S, Felsen D, Krueger JG, Carucci JA. Langerhans cells from human cutaneous squamous cell carcinoma induce strong type 1 immunity. J Invest Dermatol. 2012 Jun; 132 (6), 1645-1655
  15. Mitsui H, Suarez-Farinas M, Belkin DA, Levenkova N, Fuentes-Duculan J, Coats I, Fujita H, Krueger JG. Combined Use of Laser Capture Microdissection and cDNA Microarray Analysis Identifies Locally Expressed Disease-Related Genes in Focal Regions of Psoriasis Vulgaris Skin Lesions. J Invest Dermatol. 2012 Jun; 132 (6), 1615-1626
  16. Gittler J, Shemer A, Suarez-Farinas M, Fuentes-Duculan J, Gulewiczk KJ, Wang CQ, Mitsui H, Cardinale I, de Guzman Strong C, Krueger JG, and Guttman-Yassky E. Progressive activation of Th2/Th22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis. J Allergy Clin Immunol. 2012 Dec; 130 (6), 1344-1354
  17. Aubert P, Suarez-Farinas M, Mitsui M, Johnson-Huang LM, Harden JL, Pierson KC, Dolan JG, Novitskaya I, Coats I, Estes J, Cowen EW, Plass N, Lee CCR, Sun HW, Lowes MA, Goldbach-Mansky R. Homeostatic tissue responses in skin biopsies from NOMID patients with constitutive overproduction of IL-1β. PLoS ONE, 2012; 7 (11), e49408

Research Achievement in 2011

English Medical Articles

  1. Li K, Yao J, Shi L, Sawada N, Chi Y, Yan Q, Matsue H, Kitamura M, Takeda M. Reciprocal regulation between proinflammatory cytokine-induced inducible NO synthase (iNOS) and connexin43 in bladder smooth muscle cells. J Biol Chem. 2011 Dec 2;286(48):41552-41562
  2. Hanawa F, Inozume T, Harada K, Kawamura T, Shibagaki N, Shimada S. A Case of Metastatic Extramammary Paget's Disease Responding to Trastuzumab plus Paclitaxel Combination Therapy. Case Rep Dermatol. 2011 Sep;3(3):223-227
  3. Shibagaki N, Okamoto T, Mitsui H, Inozume T, Kanzaki M, Shimada S. Novel immunotherapeutic approaches to skin cancer treatments using protein transduction technology. J Dermatol Sci. 2011 Mar;61(3):153-161
  4. Hanada K, Wang QJ, Inozume T, Yang JC. Molecular identification of an MHC-independent ligand recognized by a human {alpha}/{beta} T-cell receptor. Blood. 2011 May 5;117(18):4816-4825
  5. Wang QJ, Hanada K, Feldman SA, Zhao Y, Inozume T, Yang JC.Development of a genetically-modified novel T-cell receptor for adoptive cell transfer against renal cell carcinoma. J Immunol Methods. 2011 Mar 7;366(1-2):43-51
  6. Kawamura T, Ogawa Y, Shimozato O, Ando T, Nakao A, Kobata T, Okumura K, Yagita H, Shimada S. CD70 is selectively expressed on Th1 but not on Th2 cells and is required for Th1-type immune responses. J Invest Dermatol. 2011 Jun;131(6):1252-1261
  7. Suzuki K, Murphy SH, Xia Y, Yokota M, Nakagomi D, Liu F, Verma IM, Nakajima H. Tumor suppressor p53 functions as a negative regulator in IgE-mediated mast cell activation. PLoS One. 2011;6(9):e25412.
  8. Iida K, Suzuki K, Yokota M, Nakagomi D, Wakashin H, Iwata A, Kawashima H, Takatori H, Nakajima H. STAT4 is required for IFN-β-induced MCP-1 mRNA expression in murine mast cells. Int Arch Allergy Immunol. 2011;155 Suppl 1:71-6.
  9. Koga S, Ikeda K, Nakagomi D, Mori M, Kuwabara S, Nakajima H. A patient with neuromyelitis optica with positive anti-Ro (SS-A) antibody presenting with intractable hiccup and nausea. Mod Rheumatol. 2011 ;21(5):561-2.
  10. Moussai D, Mitsui H, Pettersen JS, Pierson KC, Shah KR, Suarez-Farinas M, Cardinale IR, Bluth MJ, Krueger JG, Carucci JA. The human cutaneous squamous cell carcinoma microenvironment is characterized by increased lymphatic density and enhanced expression of macrophage-derived VEGF-C.　J Invest Dermatol. 2011 Jan;131(1):229-236
  11. Belkin DA, Mitsui H, Felsen D, and Carucci JA. VEGF-C-producing macrophages in cutaneous squamous cell carcinoma. Expert Rev Dermatol. 2011; 6, 643-651

Research Achievement in 2010

English Medical Articles

  1. Inozume T, Hanada K, Wang QJ, Ahmadzadeh M, Wunderlich JR, Rosenberg SA, Yang JC. Selection of CD8+PD-1+ lymphocytes in fresh human melanomas enriches for tumor-reactive T cells. 　J Immunother. 2010 Nov-Dec;33(9):956-64
  2. Kanzaki M, Okamoto T, Mitsui H, Shibagaki N, Shimada S. A novel immunotherapeutic approach to melanoma-bearing hosts with protein-transduction domain-containing immunogenic foreign antigens. 　J Dermatol Sci. 2010 Nov;60(2):84-94
  3. Okamoto T, Inozume T, Mitsui H, Kanzaki M, Harada K, Shibagaki N, Shimada S. Overexpression of GRIM-19 in cancer cells suppresses STAT3-mediated signal transduction and cancer growth. 　Mol Cancer Ther. 2010 Aug;9(8):2333-43.
  4. Aoki R, Mitsui H, Harada K, Kawamura T, Shibagaki N, Tsukamoto K, Murata S, Shimada S. A case of lymphoepithelioma-like carcinoma of the skin associated with Epstein-Barr virus infection. 　J Am Acad Dermatol. 2010 Apr;62(4):681-4.
  5. Mitsui H, Okamoto T, Kanzaki M, Inozume T, Shibagaki N, Shimada S. Intradermal injections of polyarginine-containing immunogenic antigens preferentially elicit Tc1 and Th1 activation and antitumour immunity. 　Br J Dermatol. 2010 Jan;162(1):29-41
  6. Fuentes-Duculan J, Suarez-Farinas M, Zaba LC, Nograles KE, Pierson KC, Mitsui H, Pensabene CA, Kzhyshkowska J, Krueger JG, Lowes MA. A Subpopulation of CD163-Positive Macrophages Is Classically Activated in Psoriasis. J Invest Dermatol. 2010 Oct; 130 (10), 2412-242

Research Achievement in 2009

English Medical Articles

  1. Nakagomi D, Harada K, Yagasaki A, Kawamura T, Shibagaki N, Shimada S. Psoriasiform eruption associated with alopecia areata during infliximab therapy. Clin Exp Dermatol. 2009 34:923-924
  2. Sakai K, Akiyama M, Yanagi T, McMillan JR, Suzuki T, Tsukamoto K, Sugiyama H, Hatano Y, Hayashitani M, Takamori K, Nakashima K, Shimizu H. ABCA12 is a major causative gene for non-bullous congenital ichthyosiform erythroderma. J Invest Dermatol. 2009 129:2306-2309
  3. Matsue H, Kambe N, Shimada S. Murine fetal skin-derived cultured mast cells: a useful tool for discovering functions of skin mast cells. J Invest Dermatol. 2009 129:1120-1125
  4. Goodman WA, Levine AD, Massari JV, Sugiyama H, McCormick TS, Cooper KD. IL-6 signaling in psoriasis prevents immune suppression by regulatory T cells. J Immunol. 2009 183:3170-3176
  5. Scholl FA, Dumesic PA, Barragan DI, Harada K, Charron J, Khavari PA. Selective role for Mek1 but not Mek2 in the induction of epidermal neoplasia. Cancer Res. 2009 69:3772-3778
  6. Ogawa Y, Kawamura T, Kimura T, Ito M, Blauvelt A, Shimada S. Gram-positive bacteria enhance HIV-1 susceptibility in Langerhans cells, but not in dendritic cells, via Toll-like receptor activation. Blood. 2009 113:5157-5166
  7. Mitsui H, Shibagaki N, Kawamura T, Matsue H, Shimada S. A clinical study of Henoch-Schonlein Purpura associated with malignancy. J Eur Acad Dermatol Venereol. 2009 23:394-401
  8. Inozume T, Hanada K, Wang QJ, Yang JC. IL-17 secreted by tumor reactive T cells induces IL-8 release by human renal cancer cells. J Immunother. 2009 32:109-117

Research Achievement in 2008

English Medical Articles

  1. Nakagomi D, Deguchi N, Yagasaki A, Harada K, Shibagaki N, Kimura M, Imaoka K, Shimada S. Rat-bite fever identified by polymerase chain reaction detection of Streptobacillus moniliformis DNA.　J Dermatol. 2008 Oct;35(10):667-70.
  2. Ogawa Y, Kawamura T, Furuhashi M, Tsukamoto K, Shimada S. Improving chemotherapeutic drug penetration in melanoma by imatinib mesylate. J Dermatol Sci. 2008 Sep;51(3):190-9.
  3. Sugiyama H, McCormick TS, Cooper KD, Korman NJ. Alefacept in the treatment of psoriasis. Clin Dermatol. 2008 Sep-Oct;26(5):503-8.
  4. Kawamura T, Koyanagi Y, Nakamura Y, Ogawa Y, Yamashita A, Iwamoto T, Ito M, Blauvelt A, Shimada S. Significant virus replication in Langerhans cells following application of HIV to abraded skin: relevance to occupational transmission of HIV. J Immunol. 2008 Mar 1;180(5):3297-304.
  5. Nagasaka A, Matsue H, Matsushima H, Aoki R, Nakamura Y, Kambe N, Kon S, Uede T, Shimada S. Osteopontin is produced by mast cells and affects IgE-mediated degranulation and migration of mast cells. Eur J Immunol. 2008 Feb;38(2):489-99.