1. Nagasaka Y, Nakamura Y, Nguyen Quoc Vuong Tran, Kobayashi Y, Nakano N, Nakao A: Deficiency of BMAL1 promotes ROS generation and enhances IgE-dependent degranulation in mast cells. Biochem Biophys Res Commun 690:149295, 2023
  2. Tran Nguyen Quoc Vuong, Le Minh Khang, Nakamura Y, Kondo T, Nakao A: A link between KIT expression, mast cell abundance and activity, and Th2-high endotype in asthmatic airways Allergy 2023 (Online ahead of print.)
  3. Kobayashi Y, Suzuki K, Tateno M, Nakamura Y, Ishimaru K, Nagasaka Y, Sakurai D, Ohashi-Doi K,Nakao A： Cha o 3, a cypress polle allergen, does not activate basophils in Japanese cypress pollinosis J Allergy Clin Immun Global　3(1):100198, 2023
  4. Thuy-An Nguyen, Minh-Khang Le, Phuc-Tan Nguyen, Nguyen Quoc Vuong Tran, Tetuo Kondo, Atsuhito Nakao： SLC22A3 that encodes organic cation transporter-3 is associated with prognosis and immunogenicity of human lung aquamous cell carcinoma.Transl Lung Cancer Res 　2023;12(10):1972-1986
  5. Phuc-Tan Nguyen, Nakamura Y , Nguyen Quoc Vuong Tran , Ishimaru K , Thuy-An Nguyen ,Kobayashi Y, Watanabe-Saito F, Okuda T, Nakano N ,Nakao A: Ethyl Caffeate Can Inhibit Aryl Hydrocarbon Receptor (AhR) Signaling and AhR-Mediated Potentiation of Mast Cell Activation.　Int J Mol Sci　24(12), 9997, 2023
  6. Nguyen Quoc Vuong Tran, Minh-Khang Le, Thuy-An Nguyen, Kondo T, Nakao A　 Association of Circadian Clock Gene Expression with Pediatric/Adolescent Asthma and Its Comorbidities. Int J Mol Sci 24(8):7477, 2023

2023

“Pushing the Edge of Allergy Research”
by Prof. Atsuhito NAKAO

Research summary

  1. Nakao A, Nakamura Y: Time will tell about mast cells: Circadian control of mast cell activation. Allergology International 71(4):425-431, 2022
  2. Nakao A: Welcome to "Circadian Immunology & Allergology": Why timing matters in diagnosing and treating allergies. [Editorial] Allergology International 71(4)423-424, 2022

2022

  1. Takahashi T, Fukudome H, Ueno HM, Watanabe-Matsuhashi S, Nakano T, Kobayashi T, Ishimaru K, Nakao A: Probiotic Supplementation and Human Milk Cytokine Profiles in Japanese Women: A Retrospective Study from an Open-Label Pilot Study. Nutrients 13(7):2285, 2021

2021

  1. Moriguchi T, Harii N, Goto J, Harada D, Sugawara H, Takamino J, Ueno M, Sakata H, Kondo K, Myose N, Nakao A, Takeda M, Haro H, Inoue O, Suzuki-Inoue K, Kubokawa K, Ogihara S, Sasaki T, Kinouchi H, Kojin H, Ito M, Onishi H, Shimizu T, Sasaki Y, Enomoto N, Ishihara H, Furuya S, Yamamoto T, Shimada S: A first case of meningitis/encephalitis associated with SARS-Coronavirus-2. Int J Infect Dis 94:55-58, 2020
  2. Nakajima S, Manita S, Yu G, Ishimaru K, Kono K, Kitamura K, Nakao A: Activation of the reward system ameliorates passive cutaneous anaphylactic reaction in mice. Allergy 2020
  3. Nakao A: Circadian Regulation of the Biology of Allergic Disease: Clock Disruption Can Promote Allergy. [Review] Frontiers in Immunology 11:1237, 2020

2020

  1. Ishimaru K, Nakajima S, Yu G, Nakamura Y, Nakao A: The Putatively Specific Synthetic REV-ERB Agonist SR9009 Inhibits IgE- and IL-33-Mediated Mast Cell Activation Independently of the Circadian Clock. Int J Mol Sci 20(24)6320, 2019
  2. Isobe J, Maeda S, Obata Y, Iizuka K, Nakamura Y, Fujimura Y, Kimizuka T, Hattori K, Yun-Gi Kim, Morita T, Kimura I, Offermanns S, Adachi T, Nakao A, Kiyono H, Takahashi D, Hase K: Commensal-bacteria-derived butyrate promotes the T cell-independent IgA response in the colon. Int Immunol 32(4):243-258, 2020
  3. Nakajima S,Ishimaru K, Kobayashi A, Guannan Yu, Nakamura Y, Oh-oka K, Suzuki-Inoue K, Kono K, Nakao A: Resveratrol inhibits IL-33–mediated mast cell activation by targeting the MK2/3–PI3K/Akt axis. Sci Rep 9(1):18423, 2019
  4. Nakamura Y, Sasaki T, Mochizuki C, Ishimaru K, Koizumi S, Shinmori H, Suzuki-Inoue K, Nakao A: Snake venom rhodocytin induces plasma extravasation via toxin-mediated interactions between platelets and mast cells. Sci Rep 9(1):15958, 2019
  5. Fukano C, Ohashi-Doi K, Lund K, Nakao A, Masuyama K, Matsuoka T: Establishment of enzyme-linked immunosorbent facilitated antigen binding as a biomarker assay for Japanese cedar pollen allergy immunotherapy. J Pharmacol Sci 140(3):223-227, 2019
  6. Ihara T, Nakamura Y, Mitsui T, Tsuchiya S, Kanda M, Kira S, Nakagomi H, Sawada N, Kamiyama M, Shigetomi E, Shinozaki Y, Yoshiyama M, Nakao A, Koizumi S, Takeda M: Intermittent restraint stress induces circadian misalignment in the mouse bladder, leading to nocturia. Sci Rep 9(1):10069, 2019
  7. Nakamura Y, Ishimaru K, Nakao A: Time-restricted feeding in rest phase alters IgE/mast cell–mediated allergic reaction in mice. Allergology International 2019
  8. Takahashi T, Fukudome H, Hiroshi M. Ueno, Watanabe-Matsuhashi S, Nakano T, Kobayashi T, Ishimaru K, Nakao A: Effects of Probiotic Supplementation on TGF-β1, TGF-β2, and IgA Levels in the Milk of Japanese Women: An Open-Label Pilot Study. frontiers in Nutrition 6:128 eCllection 2019

2019

  1. Ihara T, Mitsui T, Nakamura Y, Kanda M, Tsuchiya S, Kira S, Nakagomi H, Sawada N, Kamiyama M, Shigetomi E, Shinozaki Y, Yoshiyama M, Nakao A, Takeda M, Koizumi S: The time-dependent variation of ATP release in mouse primary-cultured urothelial cells is regulated by the clock gene. Neurourol Urodyn 37(8)2535-2543, 2018
  2. Ihara T, Mitsui T, Nakamura Y, Kanda M, Tsuchiya S, Kira S, Nakagomi H, Sawada N, Kamiyama M, Hirayama Y, Shigetomi E, Shinozaki Y, Yoshiyama M, Nakao A, Takeda M, Koizumi S: The oscillation of intracellular Ca2+ influx associated with the circadian expression of Piezo1 and TRPV4 in the bladder urothelium. Scientific Reports 8(1)5699, 2018
  3. Ihara T, Mitsui T, Nakamura Y, Kanda M, Tsuchiya S, Kira S, Nakagomi H, Sawada N, Hirayama Y, Shibata K, Shigetomi E, Shinozaki Y, Yoshiyama M, Nakao A, Takeda M, Koizumi S: The Circadian expression of Piezo1, TRPV4, Connexin26, and VNUT, associated with the expression levels of the clock genes in mouse primary cultured urothelial cells. Neurourol Urodyn 37(3)942-951, 2018
  4. Nakao A: Clockwork Allergy:How the Circadian Clock Underpins Allergic Reactions. [Review] J Allergy Clin Immun 142(4):1021-1031, 2018
  5. Matsuzawa T, Nakamura Y, Ogawa Y, Ishimaru K, Goshima F, Shimada S, Nakao A, Kawamura T: Differential Day–Night Outcome to HSV-2 Cutaneous Infection. Journal of Investigative Dermatology 138(1)233-236, 2018

2018

  1. Wada M, Orihara K, Kamagata M, Hama K, Sasaki H, Haraguchi A, Miyakawa H, Nakao A, Shibata S: Circadian clock-dependent increase in salivary IgA secretion modulated by sympathetic receptor activation in mice. Scientific Reports 7 Article number:8802, 2017
  2. Thu Le HP, Nakamura Y, Oh-oka K, Ishimaru K, Nakajima S, Nakao A: The frequency of Th17 cells in the small intestine exhibits a dayenight variation dependent on circadian clock activity. Biochem Biophys Res Commun 490(2)290-295, 2017
  3. Ihara T, Mitsui T, Kira S, Miyamoto T, Sawada N, Nakagomi H, Yoshiyama M, Takeda M, Nakamura Y, Nakao A, Shinozaki Y, Koizumi S: The Clock mutant mouse is a novel experimental model for nocturia and nocturnal polyuria. Neurourology and Urodynamics 36(4)1034-1038, 2017
  4. Oh-oka K, Kojima Y, Uchida K, Yoda M, Ishimaru K, Nakajima S, Hemmi J, Kano H, Fujii-Kuriyama Y, Katoh R, Ito H, Nakao A: Induction of colonic regulatory T cells by 5-aminosalicylic acid (5-ASA) by activating the aryl hydrocarbon receptor. Cell Mol Gastroenterol Hepatol 4(1)135-151, 2017
  5. Kawauchi T, Ishimaru K, Nakamura Y, Nakano N, Hara M, Ogawa H, Okumura K, Shibata S, Nakao A: Clock-dependent temporal regulation of IL-33/ST2-mediated mast cell response. Allergology International 66(3)472-478, 2017
  6. Nakamura Y, Ishimaru K, Shibata S, Nakao A: Regulation of plasma histamine levels by the mast cell clock and its modulation by stress. Scientific Reports 7 Article number:39934, 2017
  7. Ihara T, Mitsui T, Nakamura Y, Kira S, Nakagomi H, Sawada N, Hirayama Y, Shibata K, Shigetomi E, Shinozaki Y, Yoshiyama M, Andersson KE, Nakao A, Takeda M, Koizumi S: Clock Genes Regulate the Circadian Expression of Piezo1, TRPV4, Connexin26, and VNUT in an Ex Vivo Mouse Bladder Mucosa. PLoS One 12(1):e0168234, 2017

2017

  1. Igarashi S, Suzuki K, Nakamura Y, Ishimaru K, Fukano C, Masuyama K, Ohashi-Doi K, Nakao A: The efficacy of sublingual immunotherapy for allergic rhinitis may vary with the time of day. Int Arch Allergy Immunol 171(2)111-118, 2016
  2. Hanihara M, Kawataki T, Oh-oka K, Mitsuka K, Nakao A, and Kinouchi H: Synergistic anti-tumor effect with indoleamine 2,3-dioxygenase inhibition and temozolomide in a murine glioma model. Journal of Neurosurgery 124(6)1594-1601, 2016
  3. Nakamura Y, Nakano N, Ishimaru K, Ando N, Katoh R, Suzuki-Inoue K, Koyanagki S, Ogawa H, Okumura K, Shibata S, Nakao A: Inhibition of IgE-mediated allergic reaction by pharmacologically targeting the circadian clock. J Allergy Clin Immun 137(4)1226-1235, 2016
  4. Aoki R, Kawamura T, Goshima F, Ogawa Y, Nakae S, Moriishi K, Nakao A, Shimada S: The alarmin IL-33 derived from HSV-2-infected keratinocytes triggers mast cell-mediated antiviral innate immunity. J Invest Dermatol 136(6)1290-1292, 2016
  5. Matsuoka S, Ishii Y, Nakao A, Abe M, Ohtsuji N, Momose S, Jin H, Arase H, Sugimoto K, Nakauchi Y, Masutani H, Maeda M, Yagita H, Komatsu N, Hino O: Establishment of a therapeutic anti-pan HLA-class Ⅱ monoclonal antibody that directly induces lymphoma cell death via large pore formation. PLoS One 11(3):e0150496, 2016

2016

  1. Tanabe K, Kitagawa E, Wada M, Haraguchi A, Orihara K, Tahara Y, Nakao A, and Shibata S: Antigen exposure in the late light period induces severe symptoms of food allergy in an OVA-allergic mouse model. Scientific Reports 5 Article number:14424, 2015
  2. Ando N, Nakamura Y, Aoki R, Ishimaru K, Ogawa H, Okumura K, Shibata S, Shimada S, Nakao A: Circadian Gene Clock Regulates Psoriasis-like Skin Inflammation in Mice. Journal of Investigative Dermatology 135:3001-3008, 2015
  3. Nakao A: IL-7:AhR We Ready for a New Cytokine to Fight Colitis? [Editorial] Dig Dis Sci 60(7)1876-1877, 2015
  4. Koyama K, Ohba T, Haro H,　and Nakao A: Positive Association of Serum Thymic Stromal Lymphopoietin with Anti-Citrullinated Peptide Antibody in Rheumatoid Arthritis. Clnical Experimental Immunology 181(2)239-243, 2015
  5. Nakao A, Nakamura Y, and Shibata S: The Circadian Clock Functions As A Potent Regulator of Allergic Reaction. [Review] Allergy 70(5)467-473, 2015
  6. Ando N, Nakamura Y, Ishimaru K, Ogawa H, Okumura K, Shimada S, and Nakao A: Allergen-specific basophil reactivity exhibits daily variations in seasonal allergic rhinitis. Allergy 70(3)319-322, 2015

2015

  1. Aihara Y, Oh-oka K, Kondo N, Ishimaru K, Hara M, Yamagata Z, Nakao A: Comparison of colostrum TGF-β2 levels between lactating women in Japan and Nepal. Asian Pacific Journal of Allergy and Immunology 32(2)178-184, 2014
  2. Fukumoto S, Toshimitsu T, Matsuoka S, Maruyama A, Oh-oka K, Takamura T, Nakamura Y, Ishimaru K, Fujii-Kuriyama Y, Ikegami S, Itou H, Nakao A:Identification of a probiotic bacteria-derived activator of the aryl hydrocarbon receptor that inhibits colitis. Immunology and Cell Biology 92(5)460-465, 2014
  3. Oh-oka K, Kono H, Ishimaru K, Miyake K, Kubota T, Ogawa H, Okumura K, shibata S, Nakao A: Expressions of tight junction proteins Occludin and Claudin-1 are under the circadian control in the mouse large intestine: implications in intestinal permeability and susceptibility to colitis.PLoS One 9(5)e98016, 2014
  4. Nakamura Y, Ishimaru K, Tahara Y, Shibata S, Nakao A: Disruption of the Suprachiasmatic Nucleus Blunts A Time of Day-Dependent Variation in Systemic Anaphylactic Reaction in Mice. Journal of Immunology Research vol.2014 Article ID474217, 2014
  5. Nakao A: Temporal regulation of cytokines by the circadian clock. [Review] Journal of Immunology Research vol.2014 Article ID 614529, 2014
  6. Aihara Y, Oh-oka K, Kondo N, Sharma J, Shrestha N, Ishimaru K, Hara M, Yamagata Z, Nakao A: Residential area, birth order, and dietary habit may influence TSLP levels in colostrum: Comparative study between Japan and Nepal. Allergology International 63(2)283-285, 2014
  7. Nakamura Y, Nakano N, Ishimaru K, Hara M, Ikegami T, Tahara Y, Katoh R, Ogawa H, Okumura K, Shibata S, Nishiyama C, and Nakao A: Circadian regulation of allergic reaction by the mast cell clock in mice.J Allergy Clin Immun 133(2)568-575.e12, 2014

2014

  1. Aoki R, Kawamura T, Goshima F, Ogawa Y, Nakaw S, Nakao A, Moriishi K, Nishiyama Y, Shimada S: Mast cells play a key role in host defense against herpes simplex virus infection through TNF-α and IL-6 production. J Invest Dermatol 133(9)2170-2179, 2013
  2. Cermakian N, Lange T, Golombek D, Sarkar D, Nakao A, Shibata S, Mazzoccoli G: Cross-talk between the circadian clock circuitry and the immune system.[Review] Chronobiol Int 30(7)870-888, 2013
  3. Zhu Y, Ohba T, Ando T, Fujita K, Koyama K, Nakamura Y, Katoh R, Haro H, Nakao A: Endogenous TGF-β activity limits TSLP expression in the intervertebral disc tissue by suppressing NF-κB activation. J Orthop Res 31(7)1144-1149, 2013
  4. Takita E, Yokota S, Tahara Y, Hirao A, Aoki N, Nakamura Y, Nakao A, Shibata S: Biological clock dysfunction exacerbates contact hypersensitivity in mice. Brit J Dermatol 168(1)39-46, 2013

2013

  1. Sugiyama T, Kitamura M, Sugita K, Hisamoto M, Okuda T, Nakao A: Grape seed extract from "Koshu" cultivar antagonizes dioxin-induced aryl hydrocarbon receptor activation. Am J Enol Viticult 64(1)146-151, 2013
  2. Okada Y, Oh-oka K, Nakamura Y, Ishimaru K, Matsuoka S, Okumura K, Ogawa H, Hisamoto M, Okuda T, Nakao A: Dietary resveratrol prevents the development of food allergy in mice. PLoS One 7(9)e44338, 2012
  3. Kawamura T, Ogawa Y, Nakamura Y, Nakamizo S, Ohta T, Nakano H, Kabashima K, Katayama I, Koizumi S, Kodama T, Nakao A, Shimada S: Severe dermatitis with loss of epidermal langerhans cells in human and mouse zinc deficiency. J Clin Invest 122(2)722-732, 2012
  4. Ouyang Y, Nakao A, Han D, Zhang L: Transforming growth factor-β(1) promotes nasal mucosal mast cell chemotaxis in murine experimental allergic rhinitis. ORL J Otorhinolaryngol Relat Spec 74(3)117-123, 2012

2012

  1. Ouyang Y, Nakao A, Fan E, Li Y, Zhao L, Zhang W, Han D, Zhang L: Decreased expression of EBI3 and Foxp3 in CD4+CD25+ regulatory T cells in murine experimental allergic rhinitis. ORL Otorhinolaryngol Relat Spec 73(6)313-320, 2011
  2. Fujita K, Ando T, Ohba T, Wako M, Sato N, Nakamura Y, Ohnuma Y, Hara Y, Kato R, Nakao A, Haro H:Age-related expression of MCP-1 and MMP-3 in mouse intervertebral disc in relation to TWEAK and TNF-α stimulation. J Orthop Res 30(4)599-605, 2011
  3. Kondo N, Suda Y, Nakao A, Oh-oka K, Suzuki K, Ishimaru K, Sato M, Tanaka T, Nagai A, Yamagata Z: Maternal psychosocial factors determining the concentrations of transforming growth factor-beta in breast milk. Pediatr Allergy Immunol 22(8)853-861, 2011
  4. Kawamura T, Ogawa Y, Shimozato O, Ando T, Nakao A, Kobata T, Okumura K, Yagita H, Shimada S: CD70 is selectively expressed on Th1 but not on Th2 cells and is required for Th1-type immune responses. J Invest Dermatol 131(6)1251-1261, 2011
  5. Nakamura Y, Harama D, Shimokawa N, Hara M, Suzuki R, Tahara Y, Ishimaru K, Katoh R, Okumura K, Ogawa H, Shibata S, Nakao A: Circadian clock gene Period2 regulates a time-of-day-dependent variation in cutanenous anaphylactic reaction. J Allergy Clin Immun 127(4)1038-1045, 2011
  6. Takamura T, Harama D, Fukumoto S, Nakamura Y, Shimokawa N, Ishimaru K, Ikegami S, Makino S, Kitamura M, Nakao A: Lactobacillus bulgaricus OLL1181 activates the aryl hydrocarbon receptor pathway and inhibits colitis. Immunology and Cell Biology 89(7)817-822, 2011

2011

  1. Shimokawa N, Nishiyama C, Nakano N, Maeda K, Suzuki R, Hara M, Tokura T, Miyajima H, Nakao A, Ogawa H, Okumura K:Suppressive effects of transcription factor GATA-1 on cell type-specific gene expression in dendritic cells. Immunogenetics 62(7)421-429, 2010
  2. Takamura T, Harama D, Matsuoka S, Shimokawa N, Nakamura Y, Okumura K, Ogawa H, Kitamura M, Nakao A: Activation of the aryl hydrocarbon receptor pathway may ameliorate dextran sodium sulfate-induced colitis in mice. Immunology and Cell Biology 88(6)685-689, 2010
  3. Ouyang Y, Miyata M, Hatsushika K, Ohnuma O, Katoh R, Ogawa H, Okumura K , Masuyama K, Nakao A: TGF-β signaling may play a role in the development of goblet cell hyperplasia in a mouse model of allergic rhinitis. Allergology International 59(3)313-319, 2010
  4. Nakao A：The role and potential use of oral TGF-β in the prevention of infant allergy. [Review] Clinical & Experimental Allergy 40:725-730, 2010

2010

  1. Miyata M, Nakamura Y, Shimokawa N, Ohnuma Y, Katoh R, Matsuoka S, Okumura K, Ogawa H, Masuyama K, Nakao A: Thymic stromal lymphopoietin is a critical mediator of IL-13-driven allergic inflammation. Eur J Immunol 39(11)3078-3083, 2009
  2. Nakamura Y, Miyata M, Ando T, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Okumura K, Nakao A: The latent form of transforming growth factor-β administered orally is activated by gastric acid in mice. J Nutr 139(8)1463-1468, 2009
  3. Nakamura Y, Miyata M, Shimokawa N,Ohnuma Y, Katoh R, Ogawa H, Okumura K, Nakao A: House dust mite allergen Der f 1 can induce the activation of latent TGFβ via its protease activity. FEBS Letters 583(12)2088-2092, 2009
  4. Harama D, Koyama K, Mukai M,Shimokawa N, Miyata M, Nakamura Y, Ohnuma Y, Ogawa H, Matsuoka S, Paton AW, Paton JC, Kitamura M, Nakao A:A sub-cytotoxic dose of subtilase cytotoxin prevents LPS-induced inflammatory responses, depending on its capacity to induce the unfolded protein response. J Immunol 183(2)1368-1374, 2009
  5. Ohba T, Haro H, Ando T, Wako M, Suenaga F, Aso Y, Koyama K, Hamada Y, Nakao A:TNF-α-induced NK-κB signaling reverses age-related declines in VEGF induction and angiogenic activity in intervertebral disc tissues. J Orthop Res 27(2)229-235, 2009
  6. Ozawa T, Miyata M, Nishimura M, Ando T, Ouyang Y, Ohba T, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Nakao A:Transforming growth factor-β activity in commercially available pasteurized cow milk provides protection against inflammation in mice. J Nutr 139(1):69-75, 2009

2009

  1. Nakamura Y, Miyata M, Ohba T, Ando T, Hatsushika K, Suenaga F, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Nakao A: Cigarette smoke extract induces thymic stromal lymphopoietin expression, leading to TH2-type immune responses and airway inflammation. J Allergy Clin Immun 122(6)1208-1214, 2008
  2. Funaki T, Ebihara N, Murakami A, Nakao A: Ex vivo transfer of Smad7 decreases damage to the corneal endothelium after penetrating keratoplasty. Jpn J Ophthalmol 52:204-210, 2008
  3. Wako M, Ohba T, Ando T, Arai Y, Koyama K, Hamada Y, Nakao A, Haro H:Mechanism of signal transduction in TWEAK-induced matrix degradation by MMP-3 up-regulation in disc tissues. Spine 33(23)2489-2494, 2008
  4. Takano S, Ando T, Hiramatsu N, Kanayama A, Maekawa S, Ohnuma Y, Enomoto N, Ogawa H, Paton AW, Paton JC, Kitamura M, Nakao A: T cell receptor-mediated signaling induces GRP78 expression in T cells: The implications in maintaining T cell viability. Biochem Biophys Res Commun 371(4)762-766, 2008
  5. Ohba T, Haro H, Ando T, Koyama K, Hatsushika K, Suenaga F, Ohnuma Y, Nakamura Y, Katoh R, Ogawa H, Hamada Y, Nakao A:A potential role of TSLP in the recruitment of macrophages to the intervertebral disc via MCP-1 induction:The implications in a herniated disc. Arthritis and Rheumatism 58(11)3510-3519, 2008
  6. Miyata M, Hatsushika K, Ando T, Shimokawa N, Ohnuma Y, Katoh R, Suto H, Ogawa H, Masuyama K, Nakao A:Mast cell regulation of epithelial TSLP expression plays an important role in the development of allergic rhinitis. Eur J Immunol 38(6)1487-1492, 2008
  7. Suenaga F, Hatsushika K, Takano S, Ando T, Ohnuma Y, Ogawa H, Nakao A:A possible link between resveratrol and TGF-β: resveratrol induction of TGF-β expression and signaling. FEBS Letters 582(5)586-590, 2008

2008

  1. Ozawa T, Koyama K, Ando T, Ohnuma Y, Hatsushika K, Ohba T, Sugiyama H, Hamada Y, Ogawa H, Okumura K, Nakao A:Thymic stromal lymphopoietin secretion of synovial fibroblasts is positively and negatively regulated by Toll-like receptors/nuclear factor-κB pathway and interferon-γ/dexamethasone. Modern Rheumatology 17(6):459-463, 2007
  2. Wako M, Haro H, Ando T, Hatsushika K, Ohba T, Iwabuchi S, Nakao A, Hamada Y: Novel function of TWEAK in inducing intervertebral disc degeneration. J Orthop Res 25(11)1438-1446, 2007
  3. Koyama K, Hatsushika K, Ando T, Sakuma M, Wako M, Kato R, Sugiyama H, Hamada Y, Ogawa H, Nakao A:Imatinib mesylate both prevents and treats the arthritis induced by type II collagen antibody in mice. Modern Rheumatology 17(4):306-310, 2007
  4. Hatsushika K, Hirota T, Harada M, Sakashita M, Kanzaki M, Takano S, Doi S, Fujita K, Enomoto T, Ebisawa M, Yoshihara S, Sagara H, Fukuda T, Masuyama K, Katoh R, Matsumoto K, Saito H, Ogawa H, Tamari M, Nakao A:Transforming Growth Factor-β2 polymorphisms are associated with childhood atopic asthma. Clin Exp Allergy 37(8):1165-74, 2007
  5. Ando T, Hatsushika K, Wako M, Ohba T, Koyama K, Ohnuma Y, Katoh R, Ogawa H, Okumura K, Luo J, Wyss-Coray T, Nakao A:Orally administered TGF-βis biologically active in the intestinal mucosa and enhances oral tolerance. J Allergy Clin Immun 120(4)916-923, 2007.
  6. Hasegawa T, Sumiyoshi K, Tsuchihashi H, Ikeda S, Nakao A, Ogawa H:FK506 inhibits the enhancing effects of TGF-beta on would healing in a rabbit dermal ulcer model. J Dermatol Sci 47(1)37-40, 2007
  7. Koyama K, Ozawa T, Hatsushika K, Ando T, Takano S, Wako M, Suenaga F, Ohnuma Y, Ohba T, Katoh R, Sugiyama H, Hamada Y, Ogawa H, Okumura K, Nakao A:A possible role for TSLP in inflammatory arthritis. Biochem Biophys Res Commun 357(1)99-104, 2007
  8. Takano S, Kanai F, Jazag A, Ijichi H, Yao J, Ogawa H, Enomoto N, Omata M, Nakao A:Smad4 is essential for down-regulation of E-cadherin induced by TGF-β in pancreatic cancer cell line PANC-1. J Biochem(Tokyo) 141(3)345-351, 2007
  9. Sakuma M, Hatsushika K, Koyama K, Katoh R, Ando T, Watanabe Y, Wako M, Kanzaki M, Takano S, Sugiyama H, Hamada Y, Ogawa H, Okumura K, Nakao A:TGF-β type I receptor kinase inhibitor down-regulates rheumatoid synoviocytes and prevents the arthritis induced by type II collagen antibody. Int Immunol 19(2)117-26, 2007
  10. Tsuchihashi H, Hasegawa T, Sumiyoshi K, Ikeda S, Ando T, Nakao A, Okumura K, Ogawa H:TWEAK inhibits TGF-β-induced contraction of normal and keloid fibroblast-embedded collagen gel. J Dermatol Sci 45(3):216-8, 2007
  11. Kanzaki M, Shibagaki N, Hatsushika K, Mitsui H, Inozume T, Okamoto A, Dobashi Y, Ogawa H, Shimada S, Nakao A:Human eosinophils have an intact Smad signaling pathway leading to a major TGF-beta target gene expression. Int Arch Allergy Imm 142(4)309-317, 2007

2007

  1. Zhang L, Sato E, Amagasaki K, Nakao A, Naganuma H:Participation of an abnormality in the transforming growth factor-beta signaling pathway in resistance of malignant glioma cells to growth inhibition induced by that factor. J Neurosurg 105(1)119-28, 2006
  2. Ando T, Ichikawa J, Wako M, Hatsushika K, Watanabe Y, Sakuma M, Tasaka K, Ogawa H, Hamada Y, Yagita H , Nakao A:TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in mouse osteoblastic MC3T3-E1 cells. Arthritis Research & Therapy 8(5):R146, 2006

2006

  1. Kanamaru Y, Sumiyoshi K, Ushio H, Ogawa H, Okumura K, Nakao A:Smad3 deficiency in mast cells provides efficient host protection against acute septic peritonitis. J Immunol 174(7)4193-7, 2005
  2. Okamoto A, Kawamura T, Kanbe K, Kanamaru Y, Ogawa H, Okumura K, Nakao A: Suppression of serum IgE response and systemic anaphylaxis in a food allergy model by orally administered high-dose TGF-β. Int Immunol 17(6)705-712, 2005
  3. Hasegawa T, Nakao A, Sumiyoshi K, Tsuchihashi H, Ogawa H: SB-431542 inhibits TGF-β- induced contraction of collagen gel by normal and keloid fibroblasts. J Dermatol Sci 39(1)33-8, 2005
  4. Mimura K, Kono K, Hanawa M, Kanzaki M, Nakao A, Ooi A, Fujii H:Trastuzumab-mediated antibody-dependent cellular cytotoxicity against esophageal squamous cell carcinoma. Clin Cancer Res. 11:4898-904, 2005
  5. Ando T, Ichikawa J, Okamoto A, Tasaka K, Nakao A, Hamada Y:Gemcitabine inhibits viability, and metastasis of Osteosarcoma cell line. J Orthopaedic Research 23(4)964-969, 2005
  6. Nakano N, Nakao A, Ishidoh K, Tsuboi R, Kominami E, Okumura K, Ogawa H: CDK5 regulates cell-cell and cell-matarix adhesion in human keratinocytes. Br J Dermatol 153(1)37-45, 2005
  7. Nakano N, Nakao A, Uchida T, Shirasaka N, Yoshizumi H, Okumura K,Tsuboi R, Ogawa H: Effects of arachidonic acid analogs on FcepsilonRI-mediated activation of mast cells. Biochim Biophys Acta. 1738:19-28, 2005

2005

  1. Inazaki K, Kanamaru Y, Kojima Y, Sueyoshi N, Okumura K, Kaneko K, Yamashiro Y, Ogawa H, Nakao A: Smad3 deficiency attenuates renal fibrosis, inflammation, and apoptosis after unilateral ureteral obstruction. Kidney Int 66:597-604, 2004
  2. Sumiyoshi K, Nakao A, Setoguchi Y, Okumura K, Ogawa H: Exogenous Smad3 accelerates wound healing in a rabbit dermal ulcer model. J Invest Dermatol 123:229-236, 2004
  3. Jin L, Nakao A, Nakayama M, Yamaguchi N, Kojima Y, Nakano N, Tsuboi R, Okumura K, Yagita H, Ogawa H: Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes. J Invest Dermatol 122:1175-1179, 2004
  4. Ushio H, Nakao A, Supajatura V, Miyake K, Okumura K, Ogawa H: MD-2 is required for the full responsiveness of mast cells to LPS but not to PGN. Biochem Biophys Res Commun 323:491-498, 2004
  5. Xu H, Okamoto A, Ichikawa J, Ando T, Tasaka K, Masuyama K, Ogawa H, Yagita H, Okumura K, Nakao A: TWEAK/Fn14 interaction stimulates human bronchial epithelial cells to produce IL-8 and GM-CSF. Biochem Biophys Res Commun 318:422-427, 2004
  6. Komine-Kobayashi M, Chou N, Mochizuki H, Nakao A, Mizuno Y, Urabe T: Dual role of Fcγ receptor in transient focal cerebral ischemia in mice. Stroke 35:958-963, 2004
  7. Prapars M, Nakao A, Nakano H, Jin L, Ogawa H: Expression of phosphorylated Smad2 in normal human epidermis. J Dermatol Sci 34:54-55, 2004
  8. Furuse Y, Hashimoto N, Maekawa M, Toyama Y, Nakao A, Iwamoto I, Sakurai K, Suzuki Y, Yagui K, Yuasa S, Toshimori K, Saito Y: Activation of the Smad pathway in glomeruli from a spontaneously diabetic rat model, OLETF rats. Nephron Exp Nephrol. 98:100-108, 2004

2004

  1. Higashi K, Inagaki Y, Fujimori K, Nakao A, Kaneko H, Nakatsuka I: IFN-γ; interferes with transforming growth factor-β signaling through direct interaction of YB-1 with Smad3. J Biol Chem 278:43470-43479, 2003
  2. Inagaki Y, Nemoto T, Kushida M, Sheng Y, Higashi K, Ikeda K, Kawada N, Shirasaki F, Takehara K, Sugiyama K, Fujii M, Yamauchi H, Nakao A　transcription and suppresses experimental hepatic fibrosis in mice. Hepatology 38:890-899, 2003
  3. Sumiyoshi K, Nakao A, Setoguchi Y, Okumura K, Tsuboi R, Ogawa H: Smads regulate collagen gel contraction by human dermal fibroblasts.Br J Dermatol 149:464-70, 2003
  4. Wongpiyabovorn J, Suto H, Ushio H, Izuhara K, Mitsuishi K, Ikeda S, Nakao A, Okumura K, Ogawa H: Up-regulation of interleukin-13 receptor α1 on human keratinocytes in the skin of psoriasis and atopic dermatitis. J Dermatol Sci 33:31-40, 2003
  5. Kanamaru Y, Nakao A, Tanaka Y, Inagaki Y, Ushio H, Shirato I, Horikoshi S, Okumura K, Ogawa H, Tomino Y. Involvement of p300 in TGF-β/Smad-pathway-mediated α2(I) collagen expression in mouse mesangial cells.　Nephron Exp Nephrol 95:e36-42, 2003
  6. Ogihara T, Watada H, Kanno R, Ikeda F, Nomiyama T, Tanaka Y, Nakao A, German MS, Kojima I, Kawamori R: p38 mitogen-activated protein kinase is involved in activin A- and HGF-mediated expression of pro-endocrine gene neurogenin3 in AR42J-B13 cells. J Biol Chem　 278:21693-21700, 2003
  7. Hasegawa T, Nakao A, Sumiyoshi K, Tsuboi R, Ogawa H: IFN-γ fails to antagonize fibrotic effect of TGF-β on keloid-derived dermal fibroblasts. J Dermatol Sci 32:19-24, 2003
  8. Sumiyoshi K, Nakao A, Setoguchi Y, Tsuboi R, Okumura K, Ogawa H:TGF-β/Smad signaling inhibits IFN-γ and TNF-α-induced TARC (CCL17) production in HaCaT cells. J Dermatol Sci 31:53-8, 2003
  9. Funaki T, Nakao A, Ebihara N, Setoguchi Y, Fukuchi Y, Okumura K, Ra C, Ogawa H, Kanai A: Smad7 suppresses the inhibitory effect of TGF-β2 on corneal endothelial cell proliferation and accelerates corneal endothelial wound closure in vitro.Cornea. 22:153-9, 2003
  10. Warnnissorn P, Nakao A, Suto H, Ushio H, Yamaguchi N, Yagita H, Okumura K, Ogawa H: TRAIL expression in atopic dermatitis. Br J Dermatol 148:829-831, 2003

2003

  1. Sumiyoshi K, Nakao A, Ushio H, Mitsuishi K, Okumura K, Tsuboi R, Ra C, Ogawa H: TGF-β1 suppresses atopic dermatitis-like skin lesions in NC/Nga mice. Clin Exp Allergy 32:309-314, 2002
  2. Suzuki R, Nakao A, Kanamaru Y, Okumura K, Ogawa H, Ra C: Localization of intestinal intraepithelial T lymphocytes involves regulation of αEβ7 expression by TGF-β. Int Immunol 14:339-345, 2002
  3. Terada Y, Hanada S, Nakao A, Kuwahara M, Sasaki S, Marumo F: Gene transfer of Smad7 using electroporation of adenovirus prevents renal fibrosis in post-obstructed kidney. Kidney Int 61 (sym.1):S94-S98, 2002
  4. Supajatura V, Ushio H, Nakao A, Akira S, Okumura K, Ra C, Ogawa H: Toll-like receptor 2 and 4 of mast cells have different functional responses in allergy and innate immunity. J Clin Invest 109:1351-1359, 2002
  5. Kanamaru Y, Nakao A, Shirato I, Okumura K, Ogawa H, Tomino Y, Ra C: Chronic graft-versus-host autoimmune disease in Fc receptorγchain-deficient mice results in lipoprotein glomerulopathy. J Am Soc Nephrol. 13:1527-1533, 2002
  6. Sagara H, Okada T, Okumura K, Ogawa H, Ra C, Fukuda T, Nakao A: Activation of TGF-β/Smad2 signaling is associated with airway remodeling in asthma. J Allergy Clin Immunol 110:249-254, 2002
  7. Kanamaru Y, Nakao A, Ra C, Okumura K, Muso E, Ogawa H, Kobayashi I, Horikoshi S, Tomino Y: Role of transforming growth factor-β/Smad signaling pathway in enhanced production of glomerular extracellular matrix in IgA nephropathy of high-serum IgA ddY mice. Nephrology 7:S151-155, 2002
  8. Okado T, Terada Y, Tanaka H, Inoshita S, Nakao A, Sasaki S: Smad7 mediates transforming growth factor-β-induced apoptosis in mesangial cells. Kidney Int 62:1178-1186, 2002.
  9. Nakao A, Sagara H, Setoguchi Y, Okada T, Okumura K, Ogawa H, Fukuda T: Expression of Smad7 in bronchial epithelial cells is inversely correlated to basement membrane thickness and airway hyperresponsiveness in patients with asthma. J Allergy Clin Immunol 110:873-878, 2002.
  10. Nakao A, Okumura K, Ogawa H: Smad7: a new key player in TGF-β-associated disease. [Review] Trends Mol Med (Formerly; Mol. Med. Today) 8:361-363, 2002
  11. Inagaki Y, Nemoto T, Nakao A: Transcriptional regulation of type I collagen gene expression by transforming growth factor-β/Smad signaling and its antagonistic factors. Connective Tissue 34:139-146, 2002

2002

  1. Inagaki Y, Mamura M, Kanamaru Y, Greenwell P, Takehara K, ten Dijke P, Nakao A: Constitutive phosphorylation and nuclear localization of Smad3 correlate to increased collagen gene transcription in activated hepatic stellate cells. J Cell Physiol 187:117-123, 2001
  2. Inagaki Y, Nemoto T, Nakao A, ten Dijke P, Kobayashi K, Takehara K, Greenwel P: Interaction between GC box binding factors and Smad proteins modulates cell lineage-specific α2(I) collagen gene transcription. J Biol Chem 276:16573-16579, 2001
  3. Kanamaru Y, Nakao A, Mamura M, Suzuki Y, Shirato I, Okumura K, Tomino Y, Ra C: Blockade of TGF-β　signaling in T cells prevents the development of experimental glomerulonephritis. J Immunol 166:2818-2823, 2001
  4. Hira K, Mitsuishi K, Kawamoto K, Suto H, Nakao A, Ra C, Ogawa H:Establishment and characterization of a murine mast cell line derived from NC/Nga mice. Int Arch Allergy Clin Immunol 125 (S1):67-70, 2001
  5. Okazaki T, Nakao A, Nakano H, Takeda K, Shimozato O, Takahashi F, Takahashi K, Yagita H, Okumura K: Impairment of bleomycin-induced lung fibrosis in CD28-deficient mice. J Immunol 167:1977-1981, 2001
  6. Supajatura S, Ushio H, Nakao A, Okumura K, Ra C, Ogawa H: Protective roles of mast cells against enterobacterial infection are mediated by Toll-like receptor 4. J Immunol 167:2250-2256, 2001
  7. Uchida T, Nakao A, Nakano N, Kuramasu A, Saito H, Okumura K, Ra C, Ogawa H: Identification of NASH1, a novel protein containing a nuclear localization signal, a sterile a motif, and a SH3 domain preferentially expressed in mast cells. Biochem Biophys Res Commun 288:137-141, 2001
  8. Palungwachira P, Chirachanakul P, Palungwachira P, Chalugun P, Nakao A, Takamori K, Ogawa H: Cutaneous findings in HIV-1-positive patients in Thailand. The Journal of Dermatology 10:584-585, 2001
  9. Nakao A: Is transforming growth factor-β1 the key to suppression of human asthma? [Review] Trends Immunol (Formerly; Immunol. Today) 22:115-118, 2001
  10. Nakao A: The TGF-β1 paradox in asthma. [Correspondence] Trends Immunol (Formerly; Immunol. Today) 22:300, 2001

2001

  1. Mamura M, Nakao A, Goto D, Kato M, Saito Y, Iwamoto I: Ligation of the T cell receptor complex results in phosphorylation of Smad2 in T lymphocytes. Biochem Biophys Res Commun 268:124-127, 2000.
  2. Umibe T, Kita Y, Nakao A, Nakajima H, Fukuda T, Yoshida S, Sakamaki T, Saito Y, Iwamoto I: Clonal expansion of T cells infilatrating in the airways of non-atopic asthmatics. Clin Exp Immunol 119:390-397, 2000.
  3. Oishi Y, Sakamoto A, Kurasawa K, Nakajima H, Nakao A, Nakagawa N, Tanabe E, Saito Y, Iwamoto I: CD4-CD8-T cells bearing invariant Vα24JαQ TCR α-chain are decreased in patients with atopic diseases. Clin Exp Immunol 119:404-411, 2000.
  4. Kumano K, Nakao A, Nakajima H, Miike S, Kurasawa K, Saito Y, Iwamoto I: Blockade of JAK2 by tyrphostin AG-490 inhibits antigen-induced eosinophil recruitment into the mouse airways. Biochem Biophys Res Commun 270:209-214, 2000.
  5. Nakajima H, Nakao A, Kumano K, Yamamoto H, Iwamoto I: Systemic T helper 2 cell activation is not sufficient for antigen-induced eosinophil recruitment into the airways. Int Arch Allergy Immunol 122 (S1):20-24, 2000.
  6. Nakao A, Miike S, Hatano M, Okumura K, Tokuhisa T, Ra C, Iwamoto I: Blockade of TGF-β/Smad signaling by overexpression of Smad7 in T cells enhances antigen-induced airway inflammation and airway reactivity. J Exp Med 192:151-158, 2000.

2000

  1. Miike S, Nakao A, Hiraguri M, Kurasawa K, Saito Y, Iwamoto I: Involvement of Jak2, but not PI3-kinase/Akt and MAP kinase pathways, in anti-apoptotic signals of GM-CSF in human eosinophils. J Leuk Biol 65:700-706, 1999
  2. Ishisaki A, Yamato K, Hashimoto S, Nakao A, Tamaki K, Nonaka K, ten Dijke P, Sugino H, Nishihara T: Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth and apoptosis in B cells. J Biol Chem 274:13637-13642, 1999
  3. Nakao A, Fujii M, Matsumura R, Kumano K, Saito Y, Miyazono K, Iwamoto I: Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice. J Clin Invest 104:5-11, 1999
  4. Heldin NE, Bergstrom D, Hermansson A, Bergenstrahle A, Nakao A, Westermark B, ten Dijke P: Lack of responsiveness to TGF-β1 in a thyroid carcinoma cell line with functional type I and type II receptors and Smad proteins, suggests a novel mechanism of TGF-β insensitivity in carcinoma cells. Mol Cell Endocrinol 153:79-90, 1999
  5. Kumano K, Nakao A, Nakajima H, Hayashi F, Kurimoto M, Okamura H, Saito Y, Iwamoto I: IL-18 enhances antigen-induced eosinophil recruitment into the mouse airways. Am J Resp Crit Care Med 160:873-878, 1999
  6. Tsukahara K, Nakao A, Hiraguri M, Miike S, Saito Y, Iwamoto I: TNF-α mediates anti-apoptotic signals via P38 MAP kinase activation in human eosinophils. Int Arch Allergy Immunol 120(S):54-59, 1999.

1999

  1. Nakao A, Kasai M, Kumano K, Nakajima H, Kurasawa K, Iwamoto I: High-dose oral tolerance prevents antigen-induced eosinophil recruitment into the mouse airways. Int Immunol 10:387-394, 1998
  2. Shimizu A, Kato M, Nakao A, Imamua T, ten Dijke P, Heldin CH, Kawabata M, Shimada S, Miyazono K: Identification of receptors and Smad proteins involved in activin signaling in a human epidermal keratinocyte cell line. Genes to Cells 3:125-134, 1998
  3. Ishisaki A, Yamato K, Nakao A, Nonaka K, Ohguchi M, ten Dijke P, Nishihara T: Smad7 is an activin-responsive gene inhibiting activin-signals for growth arrest and apoptosis. J Biol Chem 273:24293-24296, 1998
  4. Souchelnytskyi S, Nakayama T, Nakao A, Moren A, Heldin CH, Christian JL, ten Dijke P: Physical and functional interaction of mouse Smad7 and xenopus Smad8 with bone morphogenetic protein receptors and transforming growth factor-β receptors. J Biol Chem 273: 25364-25370, 1998
  5. Kasai M, Kumano K, Kurasawa K, Nakao A, Saito Y, Iwamoto I: Blockade of CD28/B7 interaction suppresses allergic eosinophilic inflammation in mice. Int Arch Allergy Immunol 117(S1):14-19, 1998
  6. Tamaki K, Souchelnytskyi S, Itoh S, Nakao A, Sampath K, Heldin CH, ten Dijke P: Intracellular signaling of osteogenic protein-1 through Smad5 activation. J Cell Physiol 177:355-363, 1998

1998

  1. Nakao A, Roijer E, Imamura T, Souchelnytskyi S, Stenman G, Heldin CH, ten Dijke P: Identification of Smad2, a human Mad-related protein in the TGF-β signaling pathway. J Biol Chem 272:2896-2900, 1997
  2. Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Ishisaki A, Oeda E, Tamaki K, Hanai J, Heldin CH, Miyazono K, ten Dijke P: TGF-β receptor mediated signaling through Smad2, Smad3, and Smad4. EMBO J 16:5353-5362, 1997
  3. Nakao A, Afrakhte M, Moren A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin NE, Heldin CH, ten Dijke P: Identification of Smad7, a TGF-β-inducible antagonist of TGF-β signaling. Nature 389:631-635, 1997

1997

  1. Iwamoto I, Kumano K, Kasai M, Kurasawa K, Nakao A:IL-12 prevents antigen-induced eosinophil recruitment into the mouse airways. Am J Resp Crit Care Med< 154:1257-1260, 1996

1996

  1. Iwamoto I, Nakao A: Induction of Th2 cell tolerance to a soluble antigen by blockade of the LFA-1-dependent pathway prevents allergic inflammation. Immunol Res 14: 263-270, 1995.

1995

  1. Nakajima H, Nakao A, Watanabe Y, Yoshida S, Iwamoto I: IFN-α inhibits antigen-induced eosinophil and CD4 T cell recruitment into tissue. J Immunol 153:1264-1270, 1994
  2. Nakao A, Nakajima H, Tomioka H, Nishimura T, Iwamoto I: Induction of T cell tolerance by pretreatment with anti-ICAM-1 and ant-LFA-1 antibodies prevents antigen-induced eosinophil recruitment into the mouse airways. J Immunol 153:5819-5825, 1994

1994

山梨大学医学部免疫学講座

〒409-3898
山梨県中央市下河東1110

TEL：055-273-9542

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Publication

　The prevalence of allergic diseases such as asthma, rhinitis, atopic dermatitis, and food allergy has reached “pandemic” proportions in industrialized countries and the costs to public health and the economy are massive and growing.
　Although we come to understand several major aspects of allergic diseases though extensive scientific efforts during the past ～50 years, there are still significant puzzles in allergic diseases that hinder the development of effective cure for the diseases.

　The research goal in our laboratory is to solve such puzzles, thereby raising new ideas for prevention and treatment of allergic diseases with great impact on medicine.

　We are currently keen about a puzzle: “How time affects allergy?”

　It has been well documented that symptoms and laboratory parameters of allergic diseases exhibit prominent ～24-hour (i.e. circadian) variations. However, the biological basis of this phenomenon remains poorly understood.

　We have recently shown that the internal time keeping system “the circadian clock” plays a key role in the temporal regulation of IgE/mast cell (or basophil)-mediated allergic reaction, and may therefore underlie the circadian pathophysiology of allergic diseases (Nakamura et al. JACI 2011, 2014, Nakamura et al. J Immunol Res 2014, Ando et al. Allergy 2015, Nakao et al. Allergy 2015).

　Given the strong influence of circadian rhythms on allergic diseases, we believe that research on how the time of day impacts allergic reaction which we may call “chronoallergology” will provide new insight into previously unknown aspects of the biology of allergies. Such knowledge should facilitate novel strategies for prevention and treatment of these diseases.