1. Nguyen Phuc Tan, Nakamura Y, Ishimaru K, Nguyen Thuy An, Tran Nguyen Quoc Vuong, Okuda T, Nakao A: Ethyl caffeate can antagonize the aryl hydrocarbon receptor signaling, which is associated with its anti-allergic property. 第72回アレルギー学会学術大会 2023年10月20-22日 東京
  2. 石丸かよ子,　中尾篤人：核内受容体REV-ERB特異的合成アゴニスト（SR9009）は概日時計非依存的にマスト細胞の活性化を阻害する. 第6回日本アレルギー学会関東地方会 2021年11月27日 東京
  3. 安藤典子, 中村勇規, 石丸かよ子, 島田眞路, 中尾篤人：スギ花粉症患者好塩基球のスギ花粉に対する反応性の日内変動. 第64回日本アレルギー学会学術大会 2015年5月26-28日 東京
  4. 福留博文, 渡辺汐美, 中埜拓, 石丸かよ子, 中尾篤人：授乳婦への乳酸菌・ビフィズス菌投与による母乳成分への影響．日本食品免疫学会設立10周年記念学術大会 2014年10月16-17日 東京

学会発表・学会活動

  1. 平成29年度 山梨大学男女共同参画学術研究奨励賞　[Summary]

受賞

公的資金

  1. 令和４年度　科学研究費補助金基盤研究(C)　代表　石丸　かよ子
  2. 令和元年度　科学研究費補助金基盤研究(C)　代表　石丸　かよ子
  3. 平成29年度　科学研究費補助金若手研究(B)　代表　石丸　かよ子
  4. 平成27年度　科学研究費補助金若手研究(B)　代表　石丸　かよ子
  5. 平成25年度　科学研究費補助金研究活動スタート支援　代表　石丸　かよ子

研究助成

2023

  1. Kobayashi Y, Suzuki K, Tateno M, Nakamura Y, Ishimaru K, Nagasaka Y, Sakurai D, Ohashi-Doi K, Nakao A:Cha o 3, a cypress polle allergen, does not activate basophils in Japanese cypress pollinosis J Allergy Clin Immun Global 3(1):100198, 2023
  2. Phuc-Tan Nguyen, Nakamura Y , Nguyen Quoc Vuong Tran , Ishimaru K , Thuy-An Nguyen ,Kobayashi Y, Watanabe-Saito F, Okuda T, Nakano N ,Nakao A: Ethyl Caffeate Can Inhibit Aryl Hydrocarbon Receptor (AhR) Signaling and AhR-Mediated Potentiation of Mast Cell Activation. Int J Mol Sci 24(12), 9997, 2023
  1. Kondo N, Suda Y, Nakao A, Oh-Oka K, Suzuki K, Ishimaru K, Sato M, Tanaka T, Nagai A, Yamagata Z:Maternal psychosocial factors determining the concentrations of transforming growth factor-beta in breast milk. Pediatr Allergy Immunol 22(8)853-861, 2011
  2. Nakamura Y, Harama D, Shimokawa N, Hara M, Suzuki R, Tahara Y, Ishimaru K, Katoh R, Okumura K, Ogawa H, Shibata S, Nakao A: Circadian clock gene Period2 regulates a time-of-day-dependent variation in cutanenous anaphylactic reaction. J Allergy Clin Immun 127(4)1038-1045, 2011
  3. Takamura T, Harama D, Fukumoto S, Nakamura Y, Shimokawa N, Ishimaru K, Ikegami S, Makino S, Kitamura M, Nakao A: Lactobacillus bulgaricus OLL1181 activates the aryl hydrocarbon receptor pathway and inhibits colitis. Immunology and Cell Biology 89(7)817-822, 2011

2011

  1. Okada Y, Oh-oka K, Nakamura Y, Ishimaru K, Matsuoka S, Okumura K, Ogawa H, Hisamoto M, Okuda T, Nakao A: Dietary Resveratrol Prevents the Development of Food Allergy in Mice. PLoS One 7(9)e44338, 2012

2012

  1. Oh-oka K, Kono H, Ishimaru K, Miyake K, Kubota T, Ogawa H, Okumura K, shibata S, Nakao A: Expressions of tight junction proteins Occludin and Claudin-1 are under the circadian control in the mouse large intestine: implications in intestinal permeability and susceptibility to colitis. PLoS One 9(5)e98016, 2014
  2. Ishimaru K*, Nakamura Y*, Tahara Y*, Shibata S, Nakao A: Disruption of the Suprachiasmatic Nucleus Blunts A Time of Day-Dependent Variation in Systemic Anaphylactic Reaction in Mice. Journal of Immunology Research vol.2014 Article ID474217, 2014 (*Thease authers contributed equally to this work.)
  3. Fukumoto S, Toshimitsu T, Matsuoka S, Maruyama A, Oh-oka K, Takamura T, Nakamura Y, Ishimaru K, Fujii-Kuriyama Y, Ikegami S, Itou H, Nakao A:Identification of a probiotic bacteria-derived activator of the aryl hydrocarbon receptor that inhibits colitis. Immunology and Cell Biology 92(5)460-465, 2014
  4. Aihara Y, Oh-oka K, Kondo N, Sharma J, Shrestha N, Ishimaru K, Hara M, Yamagata Z, Nakao A: Residential area, birth order, and dietary habit may influence TSLP levels in colostrum: Comparative study between Japan and Nepal. Allergology International 63(2)283-285, 2014
  5. Nakamura Y, Nakano N, Ishimaru K, Hara M, Ikegami T, Tahara Y, Katoh R, Ogawa H, Okumura K, Shibata S, Nishiyama C, and Nakao A: Circadian regulation of allergic reaction by the mast cell clock in mice. J Allergy Clin Immun 133(2)568-575.e12, 2014
  6. Aihara Y, Oh-oka K, Kondo N, Ishimaru K, Hara M, Yamagata Z, Nakao A: Comparison of colostrum TGF-β2 levels between lactating women in Japan and Nepal. Asian Pacific Journal of Allergy and Immunology 32(2)178-184, 2014

2014

  1. Ando N, Nakamura Y, Aoki R, Ishimaru K, Ogawa H, Okumura K, Shibata S, Shimada S, Nakao A: Circadian Gene Clock Regulates Psoriasis-like Skin Inflammation in Mice. Journal of Investigative Dermatology 135:3001-3008, 2015
  2. Ando N, Nakamura Y, Ishimaru K, Ogawa H, Okumura K, Shimada S, and Nakao A: Allergen-specific basophil reactivity exhibits daily variations in seasonal allergic rhinitis. Allergy 70(3)319-322, 2015

2015

  1. Igarashi S, Suzuki K, Nakamura Y, Ishimaru K, Fukano C, Masuyama K, Ohashi-Doi K, Nakao A: The efficacy of sublingual immunotherapy for allergic rhinitis may vary with the time of day. Int Arch Allergy Immunol 171(2)111-118, 2016
  2. Nakamura Y, Nakano N, Ishimaru K, Ando N, Katoh R, Suzuki-Inoue K, Koyanagki S, Ogawa H, Okumura K, Shibata S, Nakao A: Inhibition of IgE-mediated allergic reaction by pharmacologically targeting the circadian clock. J Allergy Clin Immun 137(4)1226-1235, 2016

2016

  1. Thu Le HP, Nakamura Y, Oh-oka K, Ishimaru K, Nakajima S, Nakao A: The frequency of Th17 cells in the small intestine exhibits a dayenight variation dependent on circadian clock activity. Biochem Biophys Res Commun 490(2)290-295, 2017
  2. Oh-oka K, Kojima Y, Uchida K, Yoda M, Ishimaru K, Nakajima S, Hemmi J, Kano H, Fujii-Kuriyama Y, Katoh R, Ito H, Nakao A: Induction of colonic regulatory T cells by 5-aminosalicylic acid (5-ASA) by activating the aryl hydrocarbon receptor. Cell Mol Gastroenterol Hepatol 4(1)135-151, 2017
  3. Kawauchi T*, Ishimaru K*, Nakamura Y, Nakano N, Hara M, Ogawa H, Okumura K, Shibata S, Nakao A: Clock-dependent temporal regulation of IL-33/ST2-mediated mast cell response. Allergology International 66(3)472-478, 2017 (*Thease authers contributed equally to this work.)
  4. Nakamura Y, Ishimaru K, Shibata S, Nakao A: Regulation of plasma histamine levels by the mast cell clock and its modulation by stress. Scientific Reports 7 Article number:39934, 2017

2017

  1. Matsuzawa T, Nakamura Y, Ogawa Y, Ishimaru K, Goshima F, Shimada S, Nakao A, Kawamura T: Differential Day–Night Outcome to HSV-2 Cutaneous Infection. Journal of Investigative Dermatology 138(1)233-236, 2018

2018

  1. Ishimaru K, Nakajima S, Yu G, Nakamura Y, Nakao A: The Putatively Specific Synthetic REV-ERB Agonist SR9009 Inhibits IgE- and IL-33-Mediated Mast Cell Activation Independently of the Circadian Clock. Int J Mol Sci 20(24)6320, 2019
  2. Nakajima S, Ishimaru K, Kobayashi A, Yu G, Nakamura Y, Oh-oka K, Suzuki-Inoue K, Kono K, Nakao A: Resveratrol inhibits IL-33–mediated mast cell activation by targeting the MK2/3–PI3K/Akt axis. Sci Rep 9(1):18423, 2019
  3. Nakamura Y, Sasaki T, Mochizuki C, Ishimaru K, Koizumi S, Shinmori H, Suzuki-Inoue K, Nakao A: Snake venom rhodocytin induces plasma extravasation via toxin-mediated interactions between platelets and mast cells. Sci Rep 9(1):15958, 2019
  4. Takahashi T, Fukudome H, Hiroshi M. Ueno, Watanabe-Matsuhashi S, Nakano T, Kobayashi T, Ishimaru K, Nakao A: Effects of Probiotic Supplementation on TGF-β1, TGF-β2, and IgA Levels in the Milk of Japanese Women: An Open-Label Pilot Study. frontiers in Nutrition 6:128 eCllection 2019

2019

  1. Nakajima S, Manita S, Yu G, Ishimaru K, Kono K, Kitamura K, Nakao A: Activation of the reward system ameliorates passive cutaneous anaphylactic reaction in mice. Allergy 75(12):3275-3279, 2020
  2. Nakamura Y, Ishimaru K, Nakao A: Time-restricted feeding in rest phase alters IgE/mast cell–mediated allergic reaction in mice. Allergology International 69(2):296-299, 2020

2020

  1. Takahashi T, Fukudome H, Ueno HM, Watanabe-Matsuhashi S, Nakano T, Kobayashi T, Ishimaru K, Nakao A: Probiotic Supplementation and Human Milk Cytokine Profiles in Japanese Women: A Retrospective Study from an Open-Label Pilot Study. Nutrients 13(7):2285, 2021

2021

  1. Kobayashi Y, Sakai K, Nguyen Quoc Vuong Tran, Ishimaru K, Sato T, Nakamura Y, Nakagomi D, Tanaka S, Koizumi S, Nakoa A: IL-33 sensitizes mast cells to Piezo1 stimulation leading to degranulation. Allergy 79(12):3517-3520, 2024
  2. Nguyen Quoc Vuong Tran, Kobayashi Y, Nakamura Y, Ishimaru K, Izuhara K, Nakao A: Transcriptomic Evidence for T Cell-Fibroblast-Keratinocyte Axis via IL-13-Periostin-Integrin in Atopic Dermatitis Allergy 79(12):3521-3525, 2024
  3. Nakamura Y, Urakami T, Ishimaru K, Nguyen Quoc Vuong Tran, Shimizu T, William Sinko, Takahashi T, Sivapriya Marappan, Kishore Narayanan, Ramulu Poddutoori, Terada Y, Nakao A: A highly selective KIT inhibitor MOD000001 suppresses IgE-mediated mast cell activation Journal of Allergy and Clinical Immunology: Global 3(3):100249, 2024
  1. 2021. 4. 1　アルソア慧央グループ社内研修　特別講演「免疫学概論」
  2. 2018. 9.22　ガールズサイエンスcafe @山梨　講演「アレルギーが起きる仕組み」

社会貢献

2024

職歴

原著

2009.4.1
山梨大学医学部免疫学講座 技術補佐員
2013.4.1
山梨大学医学部免疫学講座 特任助教
2018.4.1
山梨大学医学部免疫学講座 助教

石丸　かよ子

山梨大学医学部免疫学講座

〒409-3898
山梨県中央市下河東1110

TEL：055-273-9542

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