• 大学院生募集
  • 特進コース生募集



  • Case report: Reversible brain atrophy with low titer anti-amphiphysin antibodies related to gastric adenocarcinoma.
    Amano R, Kim YJ, Yoshida T, Hara M, Nakajima H, Ohtsuka, T., Yazawa M.
    Frontiers in Neurology 14, 2023. doi.org/10.3389/fneur.2023.1211814

  • Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms.
    Shima Y., Sasagawa S., Ota N., Oyama R., Tanaka M., Kubota-Sakashita M., Kawakami H., Kobayashi M., Takubo N., [...] AND Nakatomi H.
    Science Translational Medicine 15(700),2023. doi.org/10.1126/scitranslmed.abq7721

  • Critical Role of the Presynaptic Protein CAST in Maintaining the Photoreceptor Ribbon Synapse Triad.
    Hagiwara a, Mizutani A, Kawamura S, Abe M, Hida Y, Sakimura K, Ohtsuka, T..
    Int. J. Mol. Sci. 24(8), 7251, 2023. doi.org/10.3390/ijms24087251 (registering DOI)

  • Experience-dependent changes in affective valence of taste in male mice.
    Hamada S, Mikami K, Ueda S, Nagase M, Nagasima T, Yamamoto M, Bito H, Takemoto-Kimura S, Ohtsuka, T., Watabe AM.
    Molecular Brain 16:28, 2023. DOI.10.1186/s13041-023-01017-x

  • A novel technique for large-fragment knock-in animal production without ex vivo handling of zygotes.
    Abe M, NakatsukasaE, Natsume R, Hamada S, Sakimura K, Watabe AM, Ohtsuka, T.
    Scientific Reports 13:2245.2023. DOI.10.1038/s41598-023-29468-1

  • Post-developmental plasticity of the primary rod pathway allows restoration of visually guided behaviors.
    Cao Y., Fajardo D., Guerrero-Given D., Samuel MA., Ohtsuka, T., Boye SE., Kamasawa N., Martemyanov KA.
    Current Biology 32(22): 4783-4796.e3.2022. DOI.org/10.1016/j.cub.2022.09.016

  • Ubap1 knock-in mice reproduced the phenotype of SPG80.
    Shimozono, K., Nan, H., Hata, T., Saito, K., Kim, YJ., Nagatomo, H., Ohtsuka, T., Koizumi, S., Takiyama, Y.
    Journal of Human Genetics 67:679-686. 2022. DOI:10.1038/s10038-022-01073-6.

  • Novel SLC9A6 Variation in Female Carriers With Intellectual Disability and Atypical Parkinsonism.
    Nan, H., Kim, YJ., Tsuchiya, M., Ishida, A., Haro, H., Hiraide, M., Ohtsuka, T., Takiyama, Y.
    Neurology Genetics 8(1), e651.2022. DOI.org/10.1212/NXG.0000000000000651

  • 2021

  • An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping.
    Hamada, S., Nagase, M., Yoshizawa, T., Hagiwara, A., Isomura, Y.*, Watabe, A.M.*, Ohtsuka, T.*
    Communications. Biology 4(1):461. 2021. doi.org/10.1038/s42003-021-01977-7

  • Planar cell polarity protein Vangl2 and its interacting protein Ap2m1 regulate dendritic branching in cortical neurons.
    Yasumura, M., Hagiwara, A., Hida, Y., Ohtsuka, T.*
    Genes to Cells 2021. doi.org/10.1111/gtc.12899

  • A Novel Heterozygous Missense Variant in the CIAO1 Gene in a Family with Alzheimer’s Disease: The Val67Ile Variant Promotes the Interaction of CIAO1 and Amyloid-β Protein Precursor.
    Nan, H., Kim, YJ., Tsuchiya, M., Fukao, T., Hara, N., Hagihara, A., Nishioka, K., Hattori, N., Hara, N., Ikeuchi, T., Ohtsuka, T.*, Takiyama, Y.*
    Journal of Alzheimer's Disease 84(2021):599-605. 2021.doi.10.3233/JAD-210706

  • 2020

  • Presynaptic development is controlled by the core active zone proteins CAST/ELKS.
    Radulovic, T., Dong, W., Oliver Goral R., Thomasm C., Veeraraghavanm P., Suarez Montesinos, M., Guerrero‐Given, D., Goff, K., Lübbert, M., Kamasawa, N., Ohtsuka, T., Young, S.M.
    J. Physiology 598(12):2431-2452. 2020.doi.org/10.1113/JP279736

  • Impaired experience-dependent maternal care in presynaptic active zone protein CAST-deficient dams.
    Hagiwara, A., Sugiyama, N., Ohtsuka, T.
    Scientific reports 10(1): 5238. 2020. doi.org/10.1038/s41598-020-62072-1

  • Double deletion of the active zone proteins CAST/ELKS in the mouse forebrain causes high mortality of newborn pups.
    Hagiwara, A., Hamada, S., Hida, Y., Ohtsuka, T.
    Molecular Brain 13(1):13. 2020. doi.10.1186/s13041-020-0557-x.2019.

  • Development of an L-type Ca2+ channel-dependent Ca2+ transient during the radial migration of cortical excitatory neurons.
    Horigane, S., Hamada, S., Kamijo, S., Yamadaa, H., Yamasaki, M., Watanabe, M., Bito, H., Ohtsuka, T., Takemoto-Kimura, S.
    Neuroscience Research 2020. doi.10.1016/j.neures.2020.06.003

  • Prickle2 and Igsf9b Coordinately Regulate the Cytoarchitecture of the Axon Initial Segment.
    Chowdhury, Md. I.H., Nishioka, T., Mishima, N., Ohtsuka, T., Kaibuchi, K., Tsuboi, D.
    Cell Structure and Function 45: 143-154, 2020. doi.org/10.1247/csf.20028

  • Neuron-enriched Phosphatase and Actin Regulator 3 (Phactr3)/ Nuclear Scaffold-Associated PP1-inhibiting Protein (Scapinin) Regulates Dendritic Morphology via Its Protein Phosphatase 1-binding Domain.
    Miyata T., Kikuchi K., Ihara D., Kaito M., Ishibashi Y., Hakamata T., Yamada T., Ishikawa M., Mizukoshi M., Shoji S., Fukuchi M., Tsuda M., Hida Y.,Ohtsuka, T.,Kaneda M., Tabuchi A.
    Biochem Biophys Res Commun 528(2): 322-329. 2020. doi.10.1016/j.bbrc.2020.05.006.

  • RFC1 repeat expansion in Japanese patients with late-onset cerebellar ataxia.
    Tsuchiya, M., Nan, H., Koh, K., Ichinose, Y., Gao, L., Shimozono, K., Hata, T., Kim, YJ., Ohtsuka, T., Cortese, A., Takiyama, Y.
    J. Hum. Genet. 2020. doi.org/10.1038/s10038-020-0807-x

  • 2019

  • ELKS/Voltage-dependent Ca2+ channel-β Subunit Module Regulates Polarized Ca2+ Influx in Pancreatic β-Cells.
    Ohara-Imaizumi, M.*, Aoyagi, K., Hida, Y., Yoshida, M., Yamauchi, H., Ohkura, M., Abe, M., Akimoto, Y., Nakamichi, Y., Nishiwaki, C., Kawakami, H., Hara, K., Sakimura, K., Nakai, J., Kakei, M., Nagamatsu, S., Ohtsuka, T.*
    Cell Reports 26: 1213-1226.2019. doi.org/10.1016/j.celrep.2018.12.106

  • Vangl2 interaction plays a role in the proteasomal degradation of Prickle2.
    Nagaoka, T., Furuse, M., Ohtsuka, T., Tsuchida, K., Kishi, M.
    Scientific Reports 9(1): 2912. 2019. doi.org/10.1038/s41598-019-39642-z

  • Role of the active zone protein, ELKS, in insulin secretion from pancreatic β-cells.
    Ohara-Imaizumi, M., Aoyagi, K., Ohtsuka, T.
    Mol Metab. 27S:S81-S91, 2019. doi.10.1016/j.molmet.2019.06.017.

  • VPS13D-related disorders presenting as a pure and complicated form of hereditary spastic paraplegia.
    Koh, K., Ishiura, H., Shimazaki, H., Tsutsumiuchi, M., Ichinose, Y., Nan, H., Hamada, S.,Ohtsuka, T., Tsuji, S., Takiyama, Y.
    Mol Genet Genomic Med. 2019. doi.10.10.1002/mgg3.1108.

  • UBAP1 mutations cause juvenile-onset hereditary spastic paraplegias (SPG80) and impair UBAP1 targeting to endosomes.
    Nan, H., Ichinose, Y., Tanaka, M., Koh, K., Ishiura, H., Mitsui, J., Mizukami, H., Morimoto, M., Hamada, S., Ohtsuka, T., Tsuji, S., Takiyama, Y.
    J Hum Genet. 64(11):1055-1065. 2019. doi.10.1038/s10038-019-0670-9.

  • 2018

  • Cytomatrix proteins CAST and ELKS regulate retinal photoreceptor development and maintenance.
    Hagiwara, A., Kitahara, Y., Grabner, C.P., Vogl, C., Abe, M., Kitta, R., Ohta, K., Nakamura, K., Sakimura, K., Moser, T., Nishi, A., Ohtsuka, T.*
    J. Cell Biol. 218(1), 3993-4006, 2018. doi: 10.1083/jcb.201704076.

  • CAST/ELKS proteins control voltage-gated Ca2+ channel density and synaptic release probability at a mammalian central synapse.
    Dong, W., Radulovic, T., Thomas, C., Montesinos, M.S., Goral, R.O., Given, D.G., Hagiwara, A., Putzke, T., Hida, Y., Abe, M., Sakimura, K., Kamasawa, N., Ohtsuka, T.*, Young, S.M*.
    Cell Reports. 24(2), 284-293.e6, 2018. doi: 10.1016/j.celrep.2018.06.024.

  • Mutations in bassoon in individuals with familial and sporadic progressive supranuclear palsy-like syndrome.
    Yabe, I., Yaguchi, H., Kato, Y., Miki, Y., Takahashi, H., Tanikawa, S., Shirai, S., Takahashi, I., Kimura, M., Hama, Y., Matsushima, M., Fujioka, S., Kano, T., Watanabe, M., Nakagawa, S., Kunieda, Y., Ikeda, Y., Hasegawa, M., Nishihara, H., Ohtsuka, T., Tanaka, S., Tsuboi, Y., Hatakeyama, S., Wakabayashi, K., Sasaki, H.
    Scientific Reports. 8(1), 819, 2018. doi: 10.1038/s41598-018-19198-0.

  • Synaptic localisation of SRF coactivators, MKL1 and MKL2, and their role in dendritic spine morphology.
    Kaneda, M., Sakagami, H., Hida, Y., Ohtsuka, T., Satou, N., Ishibashi, Y., Fukuchi, M., Krysiak, A., Ishikawa, M., Ihara, D., Kalita, K., Tabuchi, A.
    Scientific Reports. 8(1), 727, 2018. doi: 10.1038/s41598-017-18905-7.

  • CAST: its molecular structure and phosphorylation-dependent regulation of presynaptic plasticity.
    Hamada, S., Ohtsuka, T.
    Neurosci. Res. 127, 25-32, 2018. doi: 10.1016/j.neures.2017.12.005.

  • Neuroimaging, genetic, and enzymatic study in a Japanese family with a GBA gross deletion.
    Ichinose, Y., Ishiura, H., Tanaka, M., Yoshimura, J., Doi, K., Umeda, T., Yamauchi, H., Tsuchiya, M., Koh, K., Yamashiro, N., Mitsui, J., Goto, J., Onishi, H., Ohtsuka, T., Shindo, K., Morishita, S., Tsuji, S., Takiyama, Y.
    Parkinsonism & Related Disorders 2018. doi:org/10.1016/j.parkreldis.2018.11.028

  • 2017

    • A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking.
      Minegishi, K., Hashimoto, M., Ajima, R., Takaoka, K., Shinohara, K., Ikawa, Y., Nishimura, H., McMahon, A., Willert, K., Okada, Y., Sasaki, H., Shi, D., Fujimori, T.,Ohtsuka, T., Igarashi, Y., Yamaguchi, T., Shimono, A., Shiratori, H., Hamada, H.
      Developmental Cell 40(5),439-452, 2017.

    • The Auxiliary Calcium Channel Subunit α2δ4 Is Required for Axonal Elaboration, Synaptic Transmission, and Wiring of Rod Photoreceptors.
      Wang, Y., Fehlhaber, K.E., Sarria, I., Cao, Y., Ingram, N.T., Guerrero-Given, D., Throesch, B., Baldwin, K., Kamasawa, N., Ohtsuka, T., Sampath, A.P., Martemyanov, K.A.
      Neuron 93(6),1359-1374,2017.

    • 2016

      • SAD-B Phosphorylation of CAST Controls Active Zone Vesicle Recycling for Synaptic Depression.
        Mochida, S.*, Hida, Y., Tanifuji, S., Hagiwara, A., Hamada, S., Abe, M., Huan, M., Yasumura, M., Kitajima, I., Sakimura, K., Ohtsuka, T.*(*corresponding authors)
        Cell Reports 16(11): 2901-13, 2016.

      • The active zone protein CAST regulates synaptic vesicle recycling and quantal size in the mouse hippocampus.
        Kobayashi, S., Hida, Y., Ishizaki, H., Inoue, E.,Tanaka-Okamoto, M., Yamasaki, M., Miyazaki, T.,Fukaya, M., Kitajima, I., Takai, Y., Watanabe, M., Ohtsuka, T.*, Manabe, T.*(*corresponding authors)
        European Journal of Neuroscience 2016 44(5):2272-2284.

      • Dopamine synapse is a neuroligin-2–mediated contact between dopaminergic presynaptic and GABAergic postsynaptic structures.
        Uchigashima, M., Ohtsuka, T., Kobayashi, K., Watanabe, M.
        PNAS 113(15): 4206-4211.2016.

      • A de novo mutation in the NALCN gene in an adult patient with cerebellar ataxia associated with intellectual disability and arthrogryposis.
        Wang, Y. Koh, K., Ichinose, Y., Yasumura, M., Ohtsuka, T., Takiyama Y.
        CLINICAL GENETICS 90(6): 556-557, 2016.


      • SAD-B kinase regulates presynaptic vesicular dynamics at hippocampal Schaffer collateral synapses and affects contextual fear memory.
        Watabe, A.M., Nagase, M., Hagiwara, A., Hida, Y., Tsuji, M., Ochiai, T., Kato, F., Ohtsuka, T.
        J. Neurochem. 136(1): 36-47, 2016.


      • The planar cell polarity protein Vangl2 bidirectionally regulates dendritic branching in cultured hippocampal neurons.
        Hagiwara, A., Yasumura, M., Hida, Y., Inoue, E., Ohtsuka, T.
        Mol. Brain 7:79,2014.


      • Identification, expression and characterization of rat isoforms of the serum response factor (SRF) coactivator MKL1.
        Ishikawa M., Shiota J., Ishibashi Y., Hakamata T., Shoji S., Fukuchi M., Tsuda M., Shirao T., Sekino Y., Ohtsuka, T., Baraban JM., Tabuchi A.
        FEBS Open Bio. 2013 387-393.

      • Vangl2, the planar cell polarity protein, is complexed with postsynaptic density protein PSD-95
        Yoshioka T., Hagiwara A, Hida Y, Ohtsuka, T.
        FEBS letters 2013 587:1453-1459.

      • CAST: functional scaffold for the integrity of the presynaptic active zone
        Ohtsuka, T.
        Neurosci. Res 2013 76:10-15


      • Deletion of the Presynaptic Scaffold CAST Reduces Active Zone Size in Rod Photoreceptors and Impairs Visual Processing
        tom Dieck S., Specht D., Strenzke N., Hida Y., Krishnamoorthy V., Schmidt K.F., Inoue E., Ishizaki H., Tanaka-Okamoto M., Miyoshi J., Hagiwara A., Brandstatter J.H., Lowel S, Gollisch T., Ohtsuka T.* and Moser T.*
        J. Neurosci 2012 32: 12192-12203.(*corresponding author)

      • Physical and Functional Interaction of the Active Zone Protein CAST/ERC2 and the β-subunit of the Voltage-dependent Ca 2+ Channel.
        Kiyonaka S, Nakajima H, Takada Y, Hida Y, Yoshioka T, Hagiwara A, Kitajima I, Mori Y and Ohtsuka, T.
        J. Biochem 2012 159:149-159.


      • Distribution of serine/threonine kinase SAD-B in mouse peripheral nerve synapse.
        Hagiwara A, Harada K, Hida Y, Kitajima I, Ohtsuka, T.
        Neuroreport 2011 22: 319-325.

      • Prickle2 is localized in the postsynaptic density and interacts with PSD-95 and NMDA receptors in the brain.
        Hida Y, Fukaya M, Hagiwara A, Deguchi-Tawarada M, Yoshioka T, Kitajima I, Inoue E, Watanabe M, and Ohtsuka, T.
        J. Biochem. 2011 149: 693-700.


      • CAST and ELKS proteins: structural and functional determinants of the presynaptic active zone.
        Hida, Y.,Ohtsuka, T.
        J. Biochem. 2010 148: 131-137.

      • Reduced expression of the ATRX gene, a chromatin-remodeling factor, causes hippocampal dysfunction in mice.
        Nogami, T., Beppu, H., Tokoro, T., Moriguchi, S., Shioda, N., Fukuaga, K., Ohtsuka, T., Ishii, I., Sasahara, M., Shimada, Y., Nishijo, H., Li, E., and
        Kitajima, I.
        Hippocampus 2010 Mar 15. [Epub ahead of print]


      • Involvement of ELKS, an active zone protein, in exocytotic release from RBL-2H3 cells.
        Nomura, H., Ohtsuka, T., Tadokoro, S., Tanaka, M., and Hirashima, N.
        Cell. Immunol. 2009 258: 204-211.


      • SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release.
        Yao, I., Takagi, H., Ageta, H., Kahyo, T., Sato, S., Hatanaka, K., Fukuda, Y., Chiba, T., Morone, N., Yuasa, S., Inokuchi, K., Ohtsuka, T., MacGregor, G.R., Tanaka, K., and Setou, M.
        2007 130: 943-957.

      • Interaction between Munc13-1 and RIM is critical for glucagon-like peptide-1 mediated rescue of exocytotic defects in Munc13-1 deficient pancreatic beta-cells.
        Kwan, E.P., Xie, L., Sheu, L., Ohtsuka, T. and Gaisano, H.Y.
        Diabetes 2007 56: 2579-2588.

      • Rab6 regulates transport and targeting of exocytotic carriers. Grigoriev, I., Splinter, D., Keijzer, N., Wulf, P.S., Demmers, J., Ohtsuka, T., Modesti, M., Maly, I.V., Grosveld, F., Hoogenraad, C.C., and Akhmanova, A.
        Dev. Cell 2007 13: 305-314.

      • Three-dimensional architecture of presynaptic terminal cytomatrix.
        Siksou, L., Rostaing, P., Lechaire, J.P., Boudier, T., Ohtsuka, T., Fejtov, A., Kao, H.T., Greengard, P., Gundelfinger, E.D., Triller, A., and Marty, S.
        J. Neurosci. 2007 27: 6868-6877.

      • The active zone protein CAST directly associates with Ligand-of-Numb protein X.
        Higa, S., Tokoro, T., Inoue, E., Kitajima, I., and Ohtsuka, T.
        Biochem. Biophys. Res. Commun. 2007 354: 686-692.

      • Localization of the active zone proteins CAST, ELKS, and Piccolo at neuromuscular junctions.
        Tokoro, T., Higa Onaga, S., Deguchi-Tawarada, M., Inoue, E., Kitajima, I., and Ohtsuka, T.
        Neuroreport 2007 18: 313-316.


      • CLASPs attach microtubele plus ends to the cell cortex through a complex with LL5beta.
        Lansbergen, G., Grigoriev, I., Mimori-Kiyosue, Y., Ohtsuka, T., Higa, S., Kitajima, I., Demmers, J., Galjart, N., Houtsmuller, A.B., Grosveld, F., and Akhmanova, A.
        Dev. Cell 2006 11: 21-32.

      • SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release.
        Inoue, E., Mochida, S., Takagi, H., Higa, S., Deguchi-Tawarada, M., Takao-Rikitsu, E., Inoue, M., Yao, I., Takeuchi, K., Kitajima, I., Setou, M., Ohtsuka, T.*, and Takai, Y.
        Neuron 2006 50: 261-275.(*corresponding author)

      • ELKS, a protein structurally related to the active zone protein CAST, is involved in Ca2+-dependent exocytosis from PC12 cells.
        Inoue, E., Deguchi-Tawarada, M., Takao-Rikitsu, E., Inoue, M., Kitajima, I., Ohtsuka, T.*, and Takai, Y.
        Genes Cells 2006 11: 659-672.

      • Active zone protein CAST is a component of conventional and ribbon synapses in mouse retina.
        Deguchi-Tawarada, M., Inoue, E., Takao-Rikitsu, E., Inoue, M., Kitajima, I., Ohtsuka, T.*, and Takai, Y.
        J. Comp. Neurol. 2006 495: 480-496.(*corresponding author)


      • ELKS, a protein structurally related to the active zone-associated protein CAST, is expressed in pancreatic beta cells and functions in insulin exocytosis: interaction of ELKS with exocytotic machinery analyzed by total internal reflection fluorescence microscopy.
        Ohara-Imaizumi, M., Ohtsuka, T., Matsushima, S., Akimoto, Y., Nishiwaki, C., Nakamichi, Y., Kikuta, T., Nagai, S., Kawakami, H., Watanabe, T., and Nagamatsu, S.
        Mol. Biol. Cell 2005 16: 3289-3300.

      • Differential distribution of release-related proteins in the hippocampal CA3 area as revealed by freeze-fracture replica labeling.
        Hagiwara, A., Fukazawa, Y., Deguchi-Tawarada, M., Ohtsuka, T., and Shigemoto, R.
        J. Comp. Neurol. 2005 489: 195-216.

      • Nectin-like molecule-1/TSLL1/SynCAM3 : a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule localizing at non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes.
        Kakunaga S., Ikeda W., Itoh, S., Deguchi-Tawarada, M., Ohtsuka, T., Mizoguchi, A., and Takai, Y.
        J. Cell Sci. 2005 118: 1267-1277.

      • Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
        Inagaki, M., Irie, K., Ishizaki, H., Tanaka-Okamoto, M., Morimoto, K., Inoue, E., Ohtsuka, T., Miyoshi, J., and Takai, Y.
        Development 2005 132: 1525-1537.


      • Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release.
        Takao-Rikitsu, E., Mochida, S., Inoue, E., Deguchi-Tawarada, M., Inoue, M., Ohtsuka, T.*, and Takai, Y.
        J. Cell Biol. 2004 164: 301-311.(*corresponding author)

      • CAST2: identification and characterization of a protein structurally related to the presynaptic cytomatrix protein CAST.
        Deguchi-Tawarada, M., Inoue, E., Takao-Rikitsu, E., Inoue, M., Ohtsuka, T.*, and Takai, Y.
        Genes Cells 2004 9: 15-23. (*corresponding author)


      • Nectin-dependent localization of synaptic scaffolding molecule (S-SCAM) at the puncta adherentia junctions formed between the mossy fibre terminals and the dendrites of pyramidal cells in the CA3 area of the mouse hippocampus.
        Yamada, A., Irie, K., Deguchi-Tawarada, M., Ohtsuka, T., and Takai, Y.
        Genes Cells 2003 8: 985-994.

      • The roles of cadherins and nectins in interneuronal synapse formation.
        Takai, Y., Shimizu, K., and Ohtsuka, T.
        Curr. Opin. Neurobiol. 2003 5: 520-526. Review.

      • Nectin-dependent localization of ZO-1 at puncta adhaerentia junctions between the mossy fiber terminals and the dendrites of the pyramidal cells in the CA3 area of adult mouse hippocampus.
        Inagaki, M., Irie, K., Deguchi-Tawarada, M., Ikeda, W., Ohtsuka, T., Takeuchi, M.,and Takai, Y.
        J. Comp. Neurol. 2003 460: 514-524.


      • CAST: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and Munc13-1.
        Ohtsuka, T.*, Takao-Rikitsu, E., Inoue, E., Inoue, M., Takeuchi, M., Matsubara, K., Deguchi-Tawarada, M., Satoh, K., Morimoto, K., Nakanishi, H., and Takai, Y.
        J. Cell Biol. 2002 158: 577-590.(*corresponding author)


      • Membrane-associated guanylate kinase with inverted orientation (MAGI)-1/brain angiogenesis inhibitor 1-associated protein (BAP1) as a scaffolding molecule for Rap small G protein GDP/GTP exchange protein at tight junctions.
        Mino, A., Ohtsuka, T., Inoue, E., and Takai, Y.
        Genes Cells 2000 5: 1009-1016.

      • Association of membrane-associated guanylate kinase-interacting protein-1 with Raf-1.
        Yao, I., Ohtsuka, T., Kawabe, H., Matsuura, Y., Takai, Y., and Hata, Y.
        Biochem. Biophys. Res. Commun. 2000 270: 538-542.

      • Importance of spatial activation of Cdc42 and rac small G proteins by frabin for microspike formation in MDCK cells.
        Yasuda, T., Ohtsuka, T., Inoue, E., Yokoyama, S., Sakisaka, T., Kodama, A., Takaishi, K., and Takai, Y.
        Genes Cells 2000 5: 583-591.


      • nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM).
        Ohtsuka, T., Hata, Y., Ide, N., Yasuda, T., Inoue, E., Inoue, T., Mizoguchi, A., and Takai, Y.
        Biochem. Biophys. Res. Commun. 1999 265: 38-44.

      • Rab11BP/Rabphilin-11, a downstream target of rab11 small G protein implicated in vesicle recycling.
        Mammoto, A., Ohtsuka, T., Hotta, I., Sasaki, T., and Takai, Y.
        J. Biol. Chem. 1999 274: 25517-25524.


      • Nexilin: a novel actin filament-binding protein localized at cell-matrix adherens junction.
        Ohtsuka, T., Nakanishi, H., Ikeda, W., Satoh, A., Momose, Y., Nishioka, H., and Takai, Y.
        J. Cell Biol. 1998 143: 1227-1238.

      • Cell-free assay system for Ras- and Rap1-dependent activation of MAP-kinase cascade.
        Shimizu, K., Ohtsuka, T., and Takai, Y.
        Methods Mol. Biol. 1998 84: 173-183. Review.


      • Different effects of various phospholipids on Ki-Ras-, Ha-Ras-, and Rap1B-induced B-Raf activation.
        Kuroda, S., Ohtsuka, T., Yamamori, B., Fukui, K., Shimizu, K., and Takai, Y.
        J. Biol. Chem. 271: 14680-14683.

      • Activation of brain B-Raf protein kinase by Rap1B small GTP-binding protein.
        Ohtsuka, T., Shimizu, K., Yamamori, B., Kuroda, S., and Takai, Y.
        J. Biol. Chem. 1996 271: 1258-1261.


      • Purification of a Ras-dependent mitogen-activated protein kinase kinase kinase from bovine brain cytosol and its identification as a complex of B-Raf and 14-3-3 proteins.
        Yamamori, B., Kuroda, S., Shimizu, K., Fukui, K., Ohtsuka, T., and Takai, Y.
        J. Biol. Chem. 1995 270: 11723-11726.

      • Doc2: a novel brain protein having two repeated C2-like domains.
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