Yukio OZAKI

Japanese CV

• Name: Yukio Ozaki　　　　　　　A cycler
• Sex:　　Male
• Date of birth: Nov. 26, 1951
• Place of birth: Tottori, Japan
• Marital status: Married
• Nationality: Japanese
• Present status: Professor, Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi
• Director, Central Laboratory Unit and Transfusion Unit, Affiliated Hospital of University of Yamanashi
• Expertise: Activation signal transduction pathways in platelets, especially of Ca++ mobilization and involvement of tyrosine kinases.

Educational Experience

• 1971 - 1976 Undergraduate student (Medicine), Faculty of Medicine, Tokyo University
• 1976 Doctor of Medicine, Tokyo University
• 1985 Ph.D., Tokyo University

Clinical Experience

• 1976 - 1980 Resident in the First Department of Internal Medicine, Affiliated Hospital of Tokyo University
• 1981 - 1985 Assistant in the First Department of Internal Medicine, Affiliated Hospital of Tokyo University

Teaching Experience

• 1986 - 1991 Lecturer in the Central Laboratory Unit, Yamanashi Medical University
• 1991 - 1996 Associate Professor in the Department of Clinical and Laboratory Medicine, Yamanashi Medical University
• 1997 - Professor and Director in the Department of Clinical and Laboratory Medicine, Yamanashi Medical University
• 2002 Professor and Director in the Department of Laboratory Medicine, Central Laboratory Unit, and Transfusion Unit, Faculty of Medicine, University of Yamanashi

Social activities

• 1. Editor-in-Chief, Journal of Japanese Society of Thrombosis and Hemostasis
• 2. Council member, Japanese Society of Thrombosis and Hemostasis
• 3. Senior Associate Editor, Thrombosis Research
• 4. Secretary General, Asian-Pacific Society of Thrombosis and HemostasisXXth ISTH @ Sydney Convention & Exhibition Centre, AU
• 5. Committee member, Japanese Society of Hematology
• 6. Committee member, Japanese Society of Clinical Hematology
• 7. Committee member, Japanese Society of Laboratory Hematology
• 8. Committee member, Japanese Society of Laboratory Medicine
• 9. Committee member, Japanese Society of Clinical Laboratory Automation
• 10. Committee member, Japanese Society of Clinical Chemistry
• 11. International member of American Society of Hematology
• 12. Member, International Society of Thrombosis and Hemostasis
• 13. Member, Japanese Society of Biochemistry

State of the Art presentation

Platelet GPIb-IX-V-dependent signaling
(The XXth Congress of the International Society on Thrombosis and Haemostasis. 2005, Sydeny, Australia)

Publications

1. Shimoyama,M., Minato,K., Tobinai,K., Horikishi,N., Deura,K., Nagatani,T., Ozaki,Y., Inada,N., Komada,H., Ibuka,T., and Hinuma,Y.:
Anti-ATLA (antibody to the adult T-cell leukemia cell-associated antigen)─positive hematologic malignancies in the Kanto district.
Japanese Journal of Clinical Oncology, 12:109-116,1982

2. Ozaki, Y. and Kume, S.:
Enhancement of chemiluminescence of the neutrophils by low concentrations of trifluoperazine.
Biochemical and Biophysical Research Communications. 118:53-59,1984

3. Ozaki,Y., Kume, S. and Ohashi, T.:
Effects of histamine agonists and antagonists on luminol dependent chemiluminescence of granulocytes.
Agents and Actions (Inflammation Research) 15:182-188,1984

4. Ozaki, Y., Iwata, J. and Ohashi, T.:
Mechanism of neutrophil chemiluminescence induced by wheat germ agglutinin: partial characterization of the antigens recognized by wheat germ agglutinin.
Blood 64:1092-1102,1984

5. Higashihara, M., Ozaki, Y., Ohashi, T. and Kume, S.:
Interaction of Solanum tuberosum agglutinin with human platelets.
Biochemical and Biophysical Research Communications, 121: 27-33,1984

6. Ozaki, Y., Ohashi, T., Ohto, H., and Maeda,H.:
A monoclonal antibody against human neutrophil: Evaluation of its effects on neutrophil function and partial characterization of the antigen.
International Journal of Haematology (Acta Haematologica Japonica) 48:980-991,1985

7. Ohto, H., Maeda, H., Shibata, Y., Chen, R-F., Ozaki, Y., Higashihara, M., Takeuchi, A., and Toyama,H.:
A novel leukocyte differentiation antigen :two monoclonal antibodies TM2 and TM3 define a 120-kd molecule present on neutrophils, monocytes, platelets, and activated lymphoblasts.
Blood 66: 873-881,1985

8. Ozaki, Y., Kume, S., Ohashi, T., and Niwa, Y.: Partial dependency of 1-oleoyl-2-acetyl-glycerol-induced superoxide production by human neutrophils on calcium ions and cytochalasin B.
Biochemical and Biophysical Research Communications 134:690-697, 1986

9. Ozaki, Y., Ohashi, T. and Niwa, Y.:
Oxygen radical production by neutrophils from patients with bacterial infection and rheumatoid arthritis.
Inflammation 10:119-130, 1986

10. Ozaki, Y., Ohashi, T. and Niwa, Y.:
A comparative study of the effects of inhibitors of the lipoxygenase pathway on neutrophil function: Inhibitory effects may not be attributed to inhibition of the lipoxygenase pathway.
Biochemical Pharmacology. 35:3481-3488, 1986

11. Ozaki, Y., Ohashi, T. and Niwa, Y.:
Evaluation of neutrophil acetyltransferase activity in patients with inflammatory disorder.
Life Sciences 39:2343-2350,1986

12. Ozaki, Y., Ohashi, T. and Niwa, Y.:
Potentiation of neutrophil biosynthesis of platelet-activating factor by cytochalasin B: Evaluation of acetyltransferase activity.
International Journal of Haematology (Acta Haematologica Japonica) 50:799-812,1987

13. Ozaki, Y., Ohashi, T., Minami, K. and Nakamura, S.:
Enhanced resistance induced by recombinant DNA-produced interleukin 1 alpha in experimentally infected mice.
Infection and Immunity 55:1436-1440,1987

14. Ozaki, Y., Ohashi, T., and Kume, S.:
Potentiation of neutrophil function by recombinant DNA-produced interleukin 1 alpha.
Journal of Leukocyte Biology 42:621-627,1987

15. Niwa, Y., Sakane, T., Ozaki, Y., Kanoh, T. and Taniguchi, S.:
Phospholipid base exchange activity in the leukocyte membranes of patients with inflammatory disorders.
American Journal of Pathology 127:317-326,1987

16. Ozaki, Y., Ohashi, T. and Niwa, Y.:
Effect of recombinant DNA-produced tumor necrosis factor on various parameters of neutrophil function.
Inflammation 12:297-309,1988

17. Ozaki,Y and Kume, S.:
Functional responses of aequorin-loaded human neutrophils. Comparison with fura 2-loaded cells.
Biochimica et Biophysica Acta 972:113-119,1988

18. Minami, A., Fujimoto, K., Ozaki, Y. and Nakamura, S.:
Augmentation of host resistance to microbial infections by recombinant human interleukin-1α.
Infection and Immunity 56:3116-3120,1988

19. Ozaki, Y., Oyama, T., and Kume, S.:
Exacerbation of toxic effect by endotoxin contamination of recombinant human tumor necrosis factor.
Cancer Chemotherapy and Pharmacology 23:231-237,1989

20. Ozaki, Y., Matsumoto, Y., Yatomi, Y., Kariya, T. and Kume, S.:
Acetyltransferase activity and production of platelet-activating factor by human neutrophils activated with various stimuli.
International Journal of Haematology.(Acta Haematologica Japonica) 52:696-706,1989

21. Ozaki, Y., Yatomi, Y., Kariya, T. and Kume, S.:
Anion channels contribute to the regulation of intracellular pH in human platelet.
Thrombosis Research 53:221-230,1989

22. Ozaki, Y., Maeda, A., Matsumoto, Y. and Kume, S.:
Effect of 5 anion channel blockers on thrombin- and ionomycin-activated platelet functions.
Biochemical Pharmacology 38:2147-2152, 1989

23. Ozaki, Y., Yatomi, Y., Kariya, T. and Kume, S.:
Correlation of intracellular and extracellular Calcium ion concentration with synergy between 1,2-sn-dioctanoyl glycerol and ionomycin in platelet arachidonic acid mobilization.
Biochimica et Biophysica Acta 1012:87-96,1989

24. Ozaki, Y. and Kume, S.:
Role of anions in platelet intracellular calcium ion rise and arachidonic acid release induced by thrombin.
Advances in Experimental Medicine and Biology 255:455-460,1989

25. Ozaki, Y., Yatomi, Y., Matsumoto, Y., and Kume, S.:
The role of intracellular pH and Ca++ on arachidonic acid metabolism in human platelets.
International Journal of Haematology (Acta Haematologica Japonica) 52: 1498-1505,1989

26. Ozaki, Y., Matsumoto, M., Yatomi, Y., Higashihara, M., and Kume, S.:
Modification of the Na+/H+ exchanger in human platelets by 1,2-dioctanoylglycerol, a protein kinase C activator.
Thrombosis and Haemostasis 64:165-171,1990

27. Ozaki, Y., Matsumoto, Y., Yatomi, Y., Higashihara, M.,Kariya, T. and Kume, S.:
Effects of various inhibitors on platelet activation by TP82, a CD9 monoclonal antibody.
Biochemical Pharmacology 40:1583-1588,1990

28. Ozaki, Y., Matsumoto, Y., Yatomi, Y., Higashihara, M., Kariya, T. and Kume, S.:
Mastoparan, a wasp venom, activates platelets via pertussis toxin-sensitive GTP-binding proteins.
Biochemical Biophysical Research Communication 170:779-785,1990

29. Ozaki, Y., Matsumoto, Y., Yatomi, Y., Higashihara, M., Kariya, T. and Kume, S.:
Ionomycin, a Ca++ ionophore, increases platelet volume independently of the Na+/H+ exchanger.
Thrombosis Research 57:87-95,1990

30. Ozaki, Y., Matsumoto, Y., Yatomi, Y., Kariya,T. and Kume, S.:
Measurement of intracellular pH in human platelets with double-wave length excitation of BCECF fluorescence.
International Journal of Haematology 53:1010-1021,1990

31. Ozaki, Y., Oyama, T., Matsumoto, Y. and Kume, S.:
Tumor necrosis factor stimulates acetyltransferase activity of human neutrophils.
Yamanashi Medical Journal 5:97-103,1990

32. Matsumoto, Y., Ozaki, Y., Kariya, T. and Kume, S.:
Potentiative effects of endothelin on platelet activation induced by epinephrine and ADP.
Biochemical Pharmacology 40:909-911,1990

33. Yatomi, Y., Higashihara, M., Ozaki, Y., Kume, S. and Kurokawa, K.:
Intracellular ionized calcium mobilization of CD9 monoclonal antibody-activated human platelets.
Biochemical Biophysical Research Communuications 171:109-115,1990

34. Ozaki, Y., Matsumoto, Y., Yatomi, Y., Higashihara, M. and Kume, S.:
Two step mobilization of arachidonic acid in platelet activation induced by low concentrations of TP82, a monoclonal antibody against CD9 antigen.
European Journal of Biochemistry 199:347-354,1991

35. Ozaki,Y., Jinnai, Y., Yatomi, Y. and Kume, S.:
Role of sodium ion gradient in facilitating extracellular calcium ion influx.
Thrombosis Research 64:179-190,1991

36. Jinnai, Y., Yatomi, Y., Ozaki, Y., Kariya, T. and Kume, S.:
Inhibitory effects of neomycin on phospholipase A2 occur at concentrations lower than those required for inhibition of phospholipase C.
Yamanashi Medical Journal 6:97-103,1991

37. Ozaki, Y., Yatomi, Y. and Kume, S.:
Evaluation of platelet calucium ion mobilization by the use of various divalent ions.
Cell Calcium 13:19-27,1992

38. Ozaki, Y., Yatomi, Y., Wakasugi, S., Shirasawa, Y., Saito, H. and Kume, S.:
Thrombin-induced calcium oscillation in human platelets and MEG-01, a megakaryoblastic leukemia cell line.
Biochemical and Biophysical Research Communications 183:864-871,1992

39. Ozaki, Y., Yatomi, Y. and Kume, S.:
Effect of oral hypoglycemic agents on platelet functions, especially of arachidonic acid metabolism.
Biochemical Pharmacology 44:687-691,1992

40. Yatomi, Y., Ozaki, Y. and Kume, S.:
Synthesis of phosphatidyl inositol 3,4-bisphosphatebut not phosphatidyl inositol 3,4,5-trisphosphate is closely correlated with protein-tyrosine phosphorylation in thrombin-activated platelets.
Biochemical and Biophysical Research Communications 186:1480-1486,1992

41. Tawata, M., Aida, K., Noguchi, T., Ozaki, Y., Kume, S., Sasaki, H., Chin, M. and Onaya, T.:
Anti-platelet action of isoliquiritigenin,an aldolase reductase inhibitor in licorice.
European Journal of Pharmacology 212:87-92,1992

42. Ozaki, Y., Satoh, K., Yatomi, Y. and Kume, S.:
Low concentrations of sodium fluoride inhibit Ca++ influx induced by receptor-mediated platelet activation.
Biochimica Biophysica Acta 1147:27-34,1993

43. Ozaki, Y., Jinnai, Y., Yatomi, Y. and Kume, S.:
Effects of Dilazep on platelet functions and volume changes in patients with diabetes mellitus.
Arzneimittel-Forschung(Drug Research) 43:536-539,1993

44. Yatomi, Y., Ozaki, Y., Koike, Y., Satoh, K. and Kume, S.:
Wheat germ agglutinin-induced intracellular calcium mobilization in human platelets; suppression by staurosporine and resistance to cyclin AMP inhibition.
Biochemical Biophysical Research Communication 191:453-458, 1993

45. Ozaki, Y., Jinnai,Y., Yatomi, Y. and Kume, S.:
Protein Kinase C inhibitors suppress disc-sphere changes of human platelets, as assessed with the shape change parameter.
European Journal of Pharmacology 235:255-256,1993

46. Yatomi, Y., Ozaki, Y., Satoh, K. and Kume, S.:
CD9 monoclonal antibody elicit staurosporine inhibitable phosphatidylinositol 4,5-bisphosphate hydrolysis, phosphatidylinositol 3,4-bisphosphate synthesis, and protein tyrosine phosphorylation.
FEBS Letter 322:285-290,1993

47. Ozaki, Y., Yatomi, Y., Jinnai, Y. and Kume, S.:
Effect of genistein, a tyrosine kinase inhibitor, on platelet functions; genistein attenuates thrombin-induced Ca++ mobilization in human platelets by affecting polyphosphoinositide turnover.
Biochemical Pharmacology 46:395-403, 1993

48. Nishida, S., Fujimura, Y., Miura, S., Yoshida, E., Sugimoto, M., Yoshioka, A., Fukui, H., Ozaki, Y., Usami,Y., Suzuki, M. and Titani, K.:
Bothrombin: a thrombin-like enzyme purified from the venom of Bothrops jararaca induces glycoprotein Ib-dependent platelet aggregation in the presence of exogenous fibrinogen.
Biochemistry 33:1843-1849,1994

49. Koike, Y., Ozaki, Y., Qi, R., Satoh, K., Kurota, K., Yatomi, Y. and Kume, S.:
Phosphatase inhibitors suppress Ca2+ influx induced by receptor-mediated intracellular Ca2+ store depletion in human platelets.
Cell Calcium 15:381-390,1994

50. Yatomi, Y., Ozaki, Y., Satoh, K. and Kume, S.:
Synthesis of phosphatidylinositol 3,4-bisphosphate is regulated by protein-tyrosine phosphorylation but the p85alpha subunit of phosphatidylinositol 3-kinase may not be a target for tyrosine kinases in thrombin-stimulated platelets.
Biochimica et Biophysica Acta 1212:337-344,1994

51. Ozaki, Y., Satoh, K., Yatomi, Y., Yamamoto, T., Shirasawa, Y. and Kume, S.:
Detection of platelet aggregates with particle counting method using light scattring.
Analytical Biochemistry 218:284-294,1994

52. Yatomi, Y., Higashihara, M., Kurakawa, K., Ozaki,Y. and Kume, S.:
Effects of the prior activation of protein kinase C on human platelet activation induced by thrombin.
International Journal of Haematology 59:201-209,1994

53. Satoh, K., Ozaki, Y., Yatomi, Y. and Kume, S.:
Effects of sulfonylurea agents on platelet arachidonic acid metabolism: stydy on platelet homogenates.
Biochemical Pharmacology 48:1053-1055,1994

54. Ozaki, Y., Satoh, K., Yatomi, Y., Miura, S., Fujimura, Y. and Kume, S.:
Protein tyrosine phosphorylation in human platelets induced by interaction between glycoprotein Ib and von Willebrand factor.
Biochimica Biophysica Acta 1243:482-488,1995

55. Qi, R., Ozaki, Y., Satoh, K., Kurota, K., Asazuma, N., Yatomi, Y. and Kume, S.:
Sulfonylurea agents inhibit platelet aggregation and [Ca++]i elevation induced by arachidonic acid.
Biochemical Pharmacology 49:1735-1739,1995

56. Yamamoto, T., Egawa, Y., Shirasawa, Y., Ozaki, Y., Satoh, K., Yatomi, Y. and Kume, S.:
A laser light scattering in situ system for counting aggregates in blood platelet aggregation.
Meas. Sci. Technol. 6:174-180,1995

57. Ozaki, Y., Satoh, K., Qi, R., Yatomi, Y., Yanagi, S., Sada, K., Yamamura, H., Yanabu, M., Nomura, S. and Kume, S.:
Anti-CD9 monoclonal antibody activates p72syk in human platelets.
Journal of Biological Chemistry 270:15119-15124,1995

58. Kuroda, K., Ozaki, Y., Qi, R., Asazuma, N., Yatomi, Y., Satoh, K., Nomura, N., Suzuki, M. and Kume, S.:
FcγII receptor-mediated platelet activation induced by anti-CD9 MoAb opens Ca++ channels which are distinct from those associated with Ca++ store depletion.
Journal of Immunology 155:4427-4436,1995

59. Yatomi, Y., Ozaki, Y., and Kume, S.:
Phosphoinositide metabolism triggered by wheat germ agglutinin in human platelets.
International Journal of Hematology 62:163-173, 1995

60. Qi, R., Ozaki, Y., Satoh, K., Kuroda, K., Asazuma, N., Yatomi, Y. and Kume, S.:
Quantitative measurement of various 5-HT receptor antagonists on platelet activation induced by serotonin.
Thrombosis Research 81:43-54, 1996

61. Kinoshita, M, Teramoto, T., Kaneko, K., Shimazu, N., Ohta, M., Koike, T., Hosogaya, S., Ozaki, Y., Kume, S. and Yamanaka, M.:
CETP is a determinant of a number of high density lipoprotein particles and a content of low density lipoprotein cholesterol.
Atherosclerosis 120: 75-82, 1996

62. Satoh, K., Ozaki, Y., Qi, R., Yang, L., Asazuma, N., Yatomi, Y. and Kume, S.:
Factors that affect the size of platelet aggregates in epinephrine-induced actvation: A study using the particle counting method based upon light scattering.
Thrombosis Research 81:515-523, 1996

63. Asazuma, N., Yatomi, Y., Ozaki, Y., Qi, R., Kuroda, K., Satoh, K., and Kume, S.:
Protein tyrosine phosphorylation and p72syk activation in human platelets stimulated by collagen is dependent upon glycoprotein Ia/IIa and actin polymerization.
Thrombosis and Haemostasis 75:648-654, 1996

64. Qi, R., Ozaki, Y., Satoh, K., Yang, L., Asazuma, N., Yatomi, Y., and Kume, S.:
Intracellular levels of cAMP and cGMP differentially modify platelet aggregate size in platelets activated with epinephrine or ADP.
Journal of Cardiovascular Pharmacology 28:215-222, 1996

65. Niwa, Y., Ozaki, Y., Kanoh, T., Akamatsu, H. and Kurisaka, M.:
Role of cytokines, tyrosine kinase, and protein kinase C on production of superoxide and induction of scavenging enzymes in human leukocytes.
Clinical Immunology and Immunopathology 79:303-313, 1996

66. Satoh, K., Ozaki, Y., Asazuma, N., Yatomi, Y., Qi, R., Kuroda, K., Yang, L. and Kume, S.:
Differential mobilization of tyrosine kinases in human platelets stimulated with thrombin or thrombin receptor agonist peptide.
Biochemical Biophysical Research Communications 225:1084-1089, 1996

67. Qi, R., Ozaki, Y., Kuroda, K., Asazuma, N., Yatomi, Y., Satoh, K., Nomura, S. and Kume, S.:
Differential activation of human platelets induced by FcγII cross-linking and by anti-CD9 monoclonal antibody.
Journal of Immunology 157, 5638-5645, 1996

68. Yang, L., Yatomi, Y., Hisano, N., Qi, R., Asazuma, N., Satoh, K., Igarashi, Y., Ozaki, Y., and Kume, S.:
Activation of protein tyrosine kinase Syk in human platelets stimulated with lysophosphatidic acid or sphingosine 1-phosphate.
Biochemical and Biophysical Research Communications 229, 440-444, 1996

69. Yabusaki, K., Shirasawa, Y., Ozaki, Y., and Kume, S.:
Ca++ localization in thapsigargin-treated MEG-01 cells.
Bioimages 4, 99-109, 1996

70. Amemiya, N., Yatomi, Y., Endo, T., Mizoe, A., Yoda-Endo, M., Yuminamochi, T., Yamamoto, M., Matsumoto, Y., Ozaki, Y. and Kume, S.:
A case of hepatocellular carcinoma with marked hyperfibrinogenemia.
Acta Haematologica. 97:236-238, 1997

71. Yanabu, M., Ozaki, Y., Nomura, S., Miyake, T., Miyazaki, Y., Kagawa, H., Asazuma, N., Satoh, K., Kume, S., Komiyama, Y. and Fukuhara, S.:
Tyrosine phosphorylation and p72syk activation by an anti-glycoprotein Ib monoclonal antibody.
Blood 89, 1590-1598, 1997

72. Yatomi, Y., Igarashi, Y., Yang, L., Hisano, N., Qi, R., Asazuma, N., Satoh, K., Ozaki, Y., and Kume, S.:
Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum.
J. Biochemistry 121, 969-973, 1997

73. Fukuda, K., Ozaki, Y., Satoh, K., Kume, S., Tawata, M., Onaya, T., Sakurada, K.,
Seto, M., and Sasaki, Y.:
Phosphorylation of myosin light chain in resting platelets from NIDDM patients is enhanced: correlation with spontaneous aggregation.
Diabetes. 46, 488-93, 1997

74. Yatomi, Y., Ozaki, Y., Satoh, K., Kume, S., Ruan, F. and Igarashi, Y.:
N,N-dimethylsphingosine phosphorylation in human platelets.
Biochemical and Biophysical Research Communications 231, 848-851, 1997

75. Hato, T., Oda, A., Ozaki, Y., Minamoto, Y., Nakatani, S., Watanabe, A., Kume, S., Ikeda, Y., and Fujita, S.:
Outside-in signaling from integrinαIIBβ3 into platelets in the absence of agonist-induced signaling.
International Journal of Hematology 65, 385-395, 1997

76. Asazuma, N., Ozaki, Y., Satoh, K., Yatomi, Y., Handa, M., Fujimura, Y., Miura, S., and Kume, S.:
Glycoprotein Ib-von Willebrand factor interactions activate tyrosine kinases in human platelets.
Blood 90, 4789-4798, 1997

77. Yatomi, Y., Yamamura, S., Ruan, F., Kume, S., Ozaki, Y., and Igarashi, Y.:
N,N,dimethylsphingosine 1-phosphate activates human platelets.
FEBS Letters 417, 341-344, 1997

78. Hisano, N., Yatomi, Y., Fujino, M., Igarashi, Y., and Ozaki, Y.:
Quantification of sphingosine derivatives in human platelets: inducible formation of free sphingosine.
Journal of Biochemistry 123, 263-268, 1998

79. Iwase, E., Tawata, M., Aida, K., Ozaki, Y., Kume, S., Satoh, K., Ruomei, Q., and Onaya, T. :
A cross-sectional evaluation of spontaneous platelet aggregation in patients with type 2 diabetes mellitus in relation to microangiopathies.
Metabolism , 47, 699-705, 1998

80. Eto, K., Takeshita, S., Ochiai, M., Ozaki, Y., Sato, T., and Isshiki, T.
Platelet aggregation in acute coronary syndrome: use of a new aggregometer with laser light scattering to assess platelet aggregability.
Cardiovascular Research 40, 223-229, 1998

81. Aida, K., Iwase, E., Tawata, M., Ozaki, Y., Kume, S., Satoh, K., Qi, R., and Onaya, T.
Agonist-induced platelet aggregation does not correlate with the varying severity of microangiopathy in patients with type 2 diabetes mellitus.
Yamanashi Medical Journal 13, 121-126, 1998

82. Ohmori, T., Yatomi, Y., Asazuma, N., Satoh, K., and Ozaki, Y.
Suppression of protein kinase C is associated with inhibition of Pyk2 tyrosine phosphorylation and enhancement of Pyk2 interaction with Src in thrombin-activated platelets. Thrombosis Research 93, 291-298, 1999

83. Inoue, K., Ozaki, Y., Satoh, K., Wu, Y., Yatomi, Y., Shin, Y., and Morita, T.
Signal transduction pathways mediated by glycoprotein Ia/IIa in human platelets: comparison with those of glycoprotein VI.
Biochemical and Biophysical Research Communications 256, 114-120, 1999

84. Yang, L., Yatomi, Y., Satoh, K., and Ozaki, Y.
Inhibitory effects of beraprost on platelet aggregation: comparative study utilizaing two methods of aggregometry.
Thrombosis Research 94, 25-32, 1999

85. Hisano, N., Yatomi, Y., Satoh, K., Akimoto, S., Mitsumata, M., Fujino, M., and Ozaki, Y.
Induction and suppression of endothelial cell apoptosis by sphingolipids: relevance to platelet-endothelial cell interaction.
Blood 93, 4293-4299, 1999

86. Yang, L., Yatomi, Y., Satoh, K., Igarashi, Y., and Ozaki, Y.
Sphingosine 1-phosphate formation and intracellular Ca2+ mobilization in human platelets: Evaluation with shingosine kinase inhibitors.
Journal of Biochemistry 126, 84-89, 1999

87. Qi, R., Ozaki, Y., Asazuma, N., Satoh, K., Yatomi, Y., Law, C-L., Hato, T., and Nomura, S.
FcγRII tyrosine phosphorylation differs between FcγRII cross-linking and platelet-activating anti-platelet monoclonal antibodies.
Biochimica et Biophysica Acta 1451, 353-363, 1999

88. Yang, L., Yatomi, Y., Miura, Y., Satoh, K., and Ozaki, Y.
Metabolism and functional effects of sphingolipids in blood cells.
British Journal of Haematology 107, 282-293, 1999

89. Motohashi, K., Shibata, S., Ozaki, Y., Yatomi, Y., Igarashi, Y.
Identification of lysophospholipid receptors in human platelets: the relation of two agonists, lysophosphatidic acid and sphingosine 1-phosphate. FEBS Letter 468, 189-193, 2000

90. Endo, T., Yatomi, Y., Amemiya, N., Mizoe, A., Iino, M., Ozawa, H., Hosogaya, S., Ozaki, Y.
Antibody studies of factor VIII inhibitor in a case with Waldenstrom's macroglobulinemia. American Journal of Hematology 63, 145-148, 2000

91. Ozaki, Y., Qi, R., Satoh, K., Asazuma, N., and Yatomi, Y.
Platelet activation mediated through membrane glycoproteins: involvement of tyrosine kinases. Seminars in Thrombosis and Hemostasis 26, 47-51, 2000

92. Satoh, K., Asazuma, N., Yatomi, Y., Fujimura, Y., Miura, S., Titani, K., and Ozaki, Y.
Activation of protein-tyrosine pathways in human platelets stimulated with A1 domain of von Willebrand factor. Platelets 　11, 171-176, 2000.

93. Sugiyama, A., Yatomi. Y., Ozaki, Y., and Hashimoto, K.
Sphingosine 1-phosphate induces sinus tachycardia and coronary vasoconstriction in the canine heart. Cardiovascular Research 46, 119-125, 2000

94. Sugiyama, A., Aye, N-N., Yatomi, Y., Ozaki, Y., and Hashimoto, K.
Effects of sphingosine 1-phosphate, a naturally occurring biologically active lysophospholipid, on the rat cardiovascular system. Japanese Journal of Pharmacology 82, 338-342, 2000

95. Ohmori, T., Yatomi, Y., Asazuma, N., Satoh, K., and Ozaki, Y.
Proline-rich tyrosine kinase 2 involvement in platelet activation: tyrosine phosphorylation mostly dependent on αIIbβ3 integrin and protein kinase C, translocation to the cytoskeleton, and association with Shc through Grb2. Biochemical Journal 347, 561-569, 2000

96. Miura, Y., Yatomi, Y., Rile, G., Ohmori, T., Satoh, K., and Ozaki, Y.
Rho-mediated phosphorylation of focal adhesion kinase and myosin light chain in human endothelial cells stimulated with sphingosine 1-phosphate, a bioactive lysophospholipid released from activated platelets. Journal of Biochemistry　 127, 909-914, 2000

97. Ohmori, T., Yatomi, Y., Inoue, K., Satoh, K., and Ozaki, Y.
Tyrosine dephosphorylation, but not phosphorylation, of p130Cas is dependent on integrin αIIbβ3-mediated aggregation in platelets: Implication of p130Cas involvement in pathways unrelated to cytoskeletal reorganization. Biochemistry 39, 5797-5807, 2000

98. Wu, Y., Ozaki, Y., Inoue, K., Satoh, K., Ohmori, T., Yatomi, Y., Owada, K.
Differential activation and redistribution of c-Src and Fyn in platelets, assessed by MoAb specific for C-terminal tyrosine-dephosphorylated c-Src and Fyn. Biochemica et Biophysica Acta 1497, 27-36, 2000

99. Qi, R-M, 　Liao, F., Inoue, K., Yatomi, Y., Satoh, K., and Ozaki, Y. Inhibition by diallyl trisulfide, a garlic component, of intracellular Ca2+ mobilization without affecting IP3 formation in activated platelets. Biochemical Pharmacology 60, 1475-1483, 2000

100. Yatomi, Y., Ohmori, T., Ge, R., Kazama, F., Okamoto, H., Sano, T., Satoh, K., Igarashi, Tigyi, G., Y., Kume, S., and Ozaki, Y. Sphingosine 1-phosphate as a major bioactive lysophospholipid released from platelets and interacting with endothelial cells. Blood 96, 3431-3438, 2000

101. Okamoto, H., Yatomi, Y., Ohmori, T., Satoh, K., Matsumoto, Y., and Ozaki, Y. Sphingosine 1-phosphate stimulates Gi- and Rho-mediated vascular endothelial cell spreading and migration. Thrombosis Research 99, 259-265, 2000

102. Niwa, Y., Akamatsu, H., Sumi, H., Ozaki, Y., and Abe, A. Evidence for degradation of cytokines in the serum of patients with atopic dermatitis by calcium-dependent protease. Archives of Dermatologic Research 292, 391-396, 2000

103. Ikeda, H., Yatomi, Y., Yanase, M., Satoh, H., Maekawa, H., Ogata, I., Ozaki, Y., Takuwa, Y., Mochida, S., and Fujiwara, K. Biological activities of novel lipid mediator sphingosine 1-phosphate in rat hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 279, G304-G310, 2000

104. Ohmori, T., Yatomi, Y., Okamoto, H., Miura, Y., Ge, R., Satoh, K., and Ozaki, Y. Gi-mediated Cas tyrosine phosphorylation in vascular endothelia cells stimulated with sphingosine 1-phosphate: possible involvement in cell motility enhancement in cooperation with Rho-mediated pathways. Journal of Biological Chemistry 276, 5274-5280, 2001

105. Suzuki-Inoue, K., Ozaki, Y., Kainoh, M., Shin, Y., Wu, Y., Yatomi, Y., Ohmori, T., Tanaka, T., Satoh, K., and Morita, T. Rhodocytin induces platelet aggregation, by interacting with glycoprotein Ia/IIa (GPIa/IIa, integrin alpha2beta1): involvement of GPIa/IIa-associated Src and protein tyrosine phosphorylation. Journal of Biological Chemistry 276, 1643-1652, 2001

106. Qi, R., Yatomi, Y., Ozaki, Y. Effects of incubation time, temperature, and anti-coagulants on platelet aggregation in whole blood. Thrombosis Research 101, 139-144, 2001

107. 　Yatomi, Y., Ozaki, Y., Ohmori, T., and Igarashi, Y. Sphingosineﾐ1 phosphate: synthesis and release. Prostaglandins 64, 107-122, 2001

108. 　Wu, Y., Ozaki, Y., Yatomi, Y., et al. Role of Fc receptor gamma-chain in platelet glycoprotein Ib-mediated signaling. Blood 　97, 3836-3845, 2001

109. 　Osada, M., Ohmori, T., Yatomi, Y., Satoh, K., Hosogaya, S., and Ozaki, Y. Involvement of Hic-5 in platelet activation: integrin αIIbβ3-dependent tyrosine phosphorylation and association with proline-rich tyrosine kinase 2. Biochemical Journal 355, 691-697, 2001

110. 　Kazama, F., Yatomi, Y., Ohmori, T., Hosogaya, S., and Ozaki, Y. Elevated expression of mitochondrial NADH dehydrogenase subunit 4/4L genes in vascular endothelial cells undergoing sphingosine-induced apoptosis. Thrombosis Haemostasis 85, 572-3, 2001

111. Ge, R., Yatomi, Y,. Qi, R., Satoh, K., and Ozaki, Y. Potentiation of ibudilast inhibition of platelet aggregation in the presence of endothelial cells. Thrombosis Research 102, 239-246, 2001

112. 　Niwa, Y., Akamatsu, H., Niwa, H., Sumi, H., Ozaki, Y., and Abe, A. Correlation of tissue and plasma RANTES levels with disease course in patients with breast or cervical cancer. Clinical and Cancer Research 7, 285-289, 2001

113. Soma, M., Tamaoki, T., Kawano, H., Ito, S., Sakamoto, M., Okada, Y., Ozaki, Y., Kanba, S., Hamada, Y., Ishihara, T., and Maeda, S. Mice lacking serum amyloid P component do not necessarily develop severe autoimmune disease. Biochemical and Biophysical Research Communications 286, 200-205, 2001

114. 　Ohmori, T., Yatomi, Y., Wu, Y., Osada, M., Satoh, K., and Ozaki, Y. Wheat germ agglutinin-induced platelet activation via platelet endothelial cell adhesion molecule-1: involvement of rapid phospholipase Cγ2 activation by Src family kinases. Biochemistry 40, 12992-13001, 2001

115. Suzuki-Inoue, K., Ozaki, Y., Yatomi, Y., Ohmori, T., and Satoh, K. Rac, a small GTP-binding protein, and p21-activated kinase are activated during platelet spreading on collagen-coated surfaces: roles of integrin alpha2 beta1. Blood 98, 3708-3716, 2001

116. Miyamoto, S., Ogawa, H., Soejima, H., Takazoe, K, Kajiwara, I., Simomura，H．，Sakamoto，T．，Yoshimura，M．，Kugiyama，K．，Yasue，H．，and Ozaki, Y. Enhanced platelet aggregation in the coronary circulation after coronary spasm. Thrombosis Research 103, 377-386, 2001

117. Miyamoto, S., Ogawa, H., Sakamoto, T., Soejima, H., Takazoe, K., Shimomura, H., Kajiwara, I., Yoshimura, M., Kugiyama, K., Nakamura, S., and Ozaki, Y. Platelet hyperaggregability persists even after the improvement of increased blood coagulation and impaired fibrinolysis with the stabilization of symptoms in patients with unstable angina. International Journal of Cardiology 80, 235-242, 2001

118. 　Satoh, K., Yatomi, Y., Kubota, F., and Ozaki, Y. Small aggregates of platelets can be detected sensitively by a flow cytometer equipped with an imaging device: mechanisms of epinephrine-induced aggregation and antiplatelet effects of beraprost. Cytometry 48: 194-201, 2002

119. Osada, M., Yatomi, Y., Ohmori, T., Ikeda, H., and Ozaki, Y. Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist. Biochemical and Biophysical Research Communications 299, 483-487, 2002

120. Wu, Y., Asazuma, N., Yatomi, Y., Takafuta, T., Berndt, M., and Ozaki, Y. Interaction between von Willebrand factor and glycoprotein Ib activates Src kinase in human platelets: role of phosphoinositide 3-kinase. Blood 　101, 3469-3476, 2003

121. Ge, R., Yatomi, Y., Takafuta, T., and Ozaki, Y. Ceramide 1-phosphate formation in neutrophils. Acta Haematologica 109, 76-83, 2003

122. 　Osada, M., Yatomi, Y., Ohmori, T., Hosogaya, S., and Ozaki, Y. Modulation of sphingosine 1-phosphate/EDG signaling by tumor necrosis factor-α in vascular endothelial cells. Thrombosis Research 108, 169-174, 2003

123. 　Miyamoto, S., Kawano, H., Sakamoto, T., Soejima, H., Kajiwara, I., Shimomura, H., Kojima, S., Hokamaki, J., Sugiyama, S., Hirai, N., Yoshimura, M., Ozaki, Y., Ogawa, H. Formation of platelet microaggregates correlates with adverse clinical outcome in patients with coronary artery disease. Thrombosis and Haemostasis 89, 681-686, 2003

124. Ohmori, T., Yatomi, Y., Osada, M., Kazama, F., Takafuta, T., Ikeda, H., and Ozaki, Y. Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2. Cardiovascular Research 58, 170-177, 2003

125. 　Yuminamochi, T., Yatomi, Y., Osada, M., Ohmori, T., Ishii, Y., Nakazawa, K., Hosogaya, S., and Ozaki, Y. Expression of the LIM proteins paxillin and Hic-5 in human tissues. Journal of Histochemistry and cytochemistry, 51, 513-521, 2003

126. Miyamoto, S., Sakamoto, T., Soejima, H., Shimomura, H., Kajiwara, I., Kojima, S., Hokamaki, J., Sugiyama, S., Yoshimura, M., Ozaki, Y., Nakamura, H., Yodoi, J., and Ogawa, H. Plasma thioredoxin levels and platelet aggregability in patients with acute myocardial infarction. American Heart Journal 146, 465-471, 2003

127. Kaneko, M., Cuyun-Lira, O., Takafuta, T., Suzuki-Inoue, K., Satoh, K., Arai, M., Yatomi, Y., and Ozaki, Y. Mechanisms of platelet retention in the collagen-coated bead column, Journal of Clinical and Laboratory Medicine, 142, 258-267, 2003

128. Ohmori, T., Yatomi, Y., Osada, M., and Ozaki, Y. Platelet-derived sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2. Journal of Thrombosis and Haemostasis 2:203-205, 2004

129. 　Satoh, K., Yatomi, Y., Osada, T., Takeda, S., Tsuruguchi, N., Kubota, F., and Ozaki, Y. Clear visual detection of circulating platelet aggregates in acute myocardial infarction using a flow cytometer equipped with an imaging device. Platelets 15, 61-62, 2004

130. Yokoo, E., Yatomi, Y., Takafuta, T., Osada, M., Okamoto, Y., Ozaki, Y. Sphingosine 1-phosphate inhibits migration of RBL-2H3 cells via S1P2: cross-talk between platelets and mast cells. Journal of Biochemistry (Tokyo), 135, 673-681, 2004

131. Miura, Y., Yatomi, Y., Ohmori, T., Osada, M., and Ozaki, Y. Independence of tumor necrosis factor-α-induced adhesion molecule expression from sphingosine 1-phosphate signaling in vascular endothelial cells. Journal of Thrombosis and Haemostasis, 2, 1019-1020, 2004

132. Naganuma, Y., Satoh, K., Yi, Q., Asazuma, N., Yatomi, Y., and Ozaki, Y. Cleavage of platelet endothelial cell adhesion molecule-1(PECAM-1) in platelets exposed to high shear stress. Journal of Thrombosis and Haemostasis, 2, 1998-2008, 2004

133. Takano, K., Asazuma, N., Satoh, K., Yatomi, Y., and Ozaki, Y. Collagen-induced generation of platelet-derived microparticles in whole blood is dependent on ADP released from red blood cells and calcium ions. Platelets 15, 223-229, 2004

134. Inoue, T., Uchida, T., Sakuma, M., Imoto, Y., Ozeki, Y., Ozaki, Y., Hikichi, Y., and Node, K. Cilostazol inhibits leukocyte integrin Mac-1, leading to a potential reduction in restenosis after coronary stent implantation. Journal of the American College of Cardiology, 44, 1408-1414, 2004

135. Amemiya, N., Yatomi, Y., Yanagi, M, Endo, T., and Ozaki, Y. Mixed blast crisis of chronic myelogenous leukemia involving minimally differentiated myeloblast and megakaryoblast lineages. Laboratory Hematology 10:254-255, 2004

136. 　Hosoda, H., Okawa-Takatsuji, M., Tanaka, A., Uwatoko, S., Aotsuka, S., Hasimoto, N., Ozaki, Y., and Ikeda, Y. Detection of autoantibody against carbonic anhydrase II in various liver diseases by enzyme-linked immunosorbent assay using appropriate conditions. Clinical Chimica Acta 342, 71-81, 2004

137. Yatomi, Y., Yamamura, S., Hisano, N., Nakahara, K., Igarashi, Y., Ozaki, Y. Sphingosine-1-phosphate breakdown in platelets. Journal of Biochemistry 136, 495-502, 2004

138. 　Ohmori, T., Yatomi, Y., Osada, M., and Ozaki, Y. The intracellular action of sphingosine 1-phosphate in GPVI-mediated Ca++ mobilization in platelets. Thrombosis Research 　115, 409-416, 2005

139. Tamaoki, T., Tezuka, H., Okada, Y., Ito, S., Shimura, H., Sakamoto, M., Endo, T., Ozaki, Y., Kanba, S., Maeda, S. Avoiding the effect of linked genes is crucial to elucidate the role of Apcs in autoimmunity. Nature Medicine, 1, 11-12, 2005

140. Arthur, J.F., Gardiner, E.E., Matzaris, M, Taylor, S.G., Wijeyewickrema, L., Ozaki, Y., Kahn, M.L., Andrews, R.K, Berndt, M.C. Glycoprotein VI is associated with GPIb-IX-V on the membrane of resting and activated platelets. Thrombosis Hemostasis 93, 716-728, 2005

141. Ozaki, Y., Asazuma, N., Suzuki-Inoue, K., and Berndt, MC. Platelet GPIb-IX-V-dependent signaling. Journal of Thrombosis and Haemostasis 3, 1745-1751, 2005

142. Kaneko M, Takafuta, T., Cuyun-Lira, O., Satoh, K., Arai, M., Yatomi, Y., Ozaki, Y. Evaluation of platelet function under high shear condition in the small-sized collagen bead column. Journal of Laboratory and Clinical Medicine 146, 64-75, 2005

143. Aoki S, Yatomi Y, Ohta, M., Osada, M., Kazama, F., Satoh, K., Nakahara, K., Ozaki, Y. Sphingosine 1-phosphate-related metabolism in the blood vessel. Journal of Biochemistry (Tokyo), 138, 47-55, 2005

144. Miyamoto, S., Kawano, H., Kudoh, T., Soejima, H., Kojima, S., Hokamaki, J., Maruyoshi, H., Sakamoto, T., Yoshimura, M., Ozaki, Y., and Ogawa, H. Usefulness of preprocedural platelet aggregation to predict restenosis after percutaneous coronary intervention. Americal Journal of Cardiology 96, 71-73, 2005


145. Shindo, S., Matsumoto, H., Kubota, K., Kojima, A., Matumoto, M., Satoh, K., and Ozaki, Y. Is the size of an abdominal aortic aneurysm associated with coagulopathy? World Journal of Surgery 29, 925-929, 2005

146. Satoh, K., Yatomi, Y., Ozaki, Y. A new method for assessment of an anti-5-HT agent, sarpogrelate hydrochloride, on platelet aggregation. Journal of Thrombosis and Haemostasis 4, 479-81. 2005

147. Yi, Q., Suzuki-Inoue, K., Asazuma, N., Inoue, O., Watson, SP., Ozaki, Y. Docking protein Gab2 positively regulates glycoprotein VI-mediated platelet activation. Biochemical and Biophysical Research Communications 337, 446-451, 2005

148. Kudoh, T., Sakamoto, T., Miyamoto, S., Matsui K., Kojima, S., Sugiyama, S., Yoshimura, M., Ozaki, Y., and Ogawa, H. Relation between platelet microaggregagtes and ankle brachial index in patients with peripheral arterial diseases. Thrombosis Research 117, 263-269, 2006

149. Suzuki-Inoue, K., Fuller, GLJ., Garc誕, A., Eble, JA., P喇lmann, S., Inoue, O., Gartner, T., Hughan. SC., Pearce. AC, Laing, GD, David, R., Theakston, G., Schweighoffer, E., Zitzmann, N., Morita, T., Tybulewicz, VLJ, Ozaki, Y., and Watson, SP. A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2. Blood 107, 542-549, 2006

150. Inoue, O., Suzuki-Inoue, K., McCarthy, OJ., Moroi, M., Ruggeri, ZM., Kunicki, TJ., Ozaki, Y., Watson, SP. Laminin stimulates spreading of platlets through integrin alpha6beta1-dependent activation of GPVI. Blood 107, 1405-1412, 2006

151. 　Ohmori, T., Yatomi, Y., Nonaka, T., Kobayashi, Y., 　Madoiwa, S., 　Mimuro, J., Ozaki, Y., Sakata, Y. 　Aspirin resistance detected with aggregometry cannot be explained by cyclooxygenase activity: involvement of other signaling pathways(s) in cardiovascular events of aspirin-treated patients. Journal of Thrombosis and Hemostasis 4: 1271-1278, 2006

152. Hosogaya, S., Ozaki, Y., Enomoto, N., Akahane, Y. Analysis of prognostic factors in the therapeutic responses to interferon in patients with chronic hepatitis C. Translational Research 148:79-86, 2006

153. 　Cuyun-Lira, O., Kaneko, M., Takafuta, T., Satoh, K., Ohnishi, M., Yatomi, Y., and Ozaki, Y. Inhibitory effects of ticlopidine on platelet function as assessed by three different methods. European Journal of Pharmaceutical Sciences 30: 21-25, 2007

154. Jin, W., Inoue, O., Tamura, N., Suzuki-Inoue, K., Satoh, K., Berndt, MC., Handa, M., Goto, G., and Ozaki, Y. A role for glycosphingolipid-enriched microdomains in platelet glycoprotein Ib-mediated platelet activation. Journal of Thrombosis and Haemostasis 5, 1034-1040, 2007

155. Suzuki-Inoue, K., Hughes, CE., Inoue, O., Kaneko, M., Cuyun-Lira, O., Takafuta, T., Watson, SP., Ozaki, Y. Involvement of Src kinases and PLCgamma2 in clot retraction. Thrombosis Research 120, 251-258, 2007

156. Fuller GL, Williams JA, Tomlinson MG, Eble JA, Hanna SL, Pohlmann S, Suzuki-Inoue K, Ozaki Y, Watson SP, Pearce AC. The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade. Journal of Biological Chemistry 282, 12397-12409, 2007

157. 　Aoki S, Yatomi Y, Shimosawa T, Yamashita H, Kitayama J, Tsuno NH, Takahashi K, Ozaki Y. The suppressive effect of sphingosine 1-phosphate on monocyte-endothelium adhesion may be mediated by the rearrangement of the endothelial integrins α5β1 and αvβ3. Journal of Thrombosis and Haemostasis. 5: 1292-1301, 2007

158. 　Aoki S, Osada M, Kaneko M, Ozaki Y, Yatomi Y. Fluid shear stress enhances the sphingosine 1-phosphate responses in cell-cell interactions between platelets and endothelial cells. Biochemical and Biophysical Research Communications 358, 1054-1057, 2007

159. Uchiyama S, Ozaki Y, Satoh K, Kondo K, Nishimaru K. Effect of sarpogrelate, a 5-HT2A antagonist, on platelet aggregation in patients with ischemic stroke: Clinical-pharmacological dose-response study. Cerebrovascular Disease 24, 264-270, 2007

160. 　Osada M, Yatomi Y, Ohmori T, Aoki S, Hosogaya S, Ozaki Y. Involvement of sphingosine 1-phosphate, a platelet-derived bioactive lipid, in contraction of mesangium cells. Journal of Biochemistry (Tokyo) 142:351-355, 2007

161. Suzuki-Inoue K, Kato Y, Inoue O, Kaneko MK, MIshima K, Yatomi Y, Yamazaki Y, Narimatsu H, and Ozaki Y. Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells. Journal of Biological Chemistry 282:25993-26001, 2007

162. Kato Y, Kaneko MK, Kunita A, Ito H, Kameyama A, Ogasawara S, Matsuura N, Hasegawa Y, Suzuki-Inoue K. Inoue O, Ozaki Y, and Narimatsu H. Molecular analysis of the pathophysiological binding of the platelet aggregation-inducing factor podoplanin to the C-type lectin-like receptor CLEC-2. Cancer Science Epub 2007

163. 　Sato H., Inoue O, Suzuki-Inoue K, and Ozaki Y. Regulation of adaptor protein GIT1 in platelets, leading to the interaction between GIT1 and integrin alphaIIb beta3. Biochemical and Biophysical Research Communications in press