Nguyen Quoc Vuong Tran, Nakamura Y, Nakao A: Unique circadian clock gene expression pattern linked to WNT signaling in severe asthmatic airways. 第73回日本アレルギー学会学術大会 2024年10月18-20日 京都
Nguyen Quoc Vuong Tran, Nakao A, Nakamura Y: [シンポジウム講演] A link between KIT expression, mast cell abundance and activity, and Th2-high endotype in asthmatic airways 第73回日本アレルギー学会学術大会 2024年10月18-20日 京都
Nguyen Thuy An, Nakao A: Organic cation transporter-3 regulates intracellular histamine levels and IgE-mediated histamine release in mast cell. 第72回アレルギー学会学術大会 2023年10月20-22日 東京
Nguyen Phuc Tan, Nakamura Y, Ishimaru K, Nguyen Thuy An, Tran Nguyen Quoc Vuong, Okuda T, Nakao A: Ethyl caffeate can antagonize the aryl hydrocarbon receptor signaling, which is associated with its anti-allergic property. 第72回アレルギー学会学術大会 2023年10月20-22日 東京
Nakao A, Nakamura Y, Urakami T, Terada Y:Identification of a highly selective
small molecule KIT inhibitor that inhibits human mast cell survival and
differentiation. EAACI Hybrid Congress 2023 2023年6月9-11日 Hamburg, Germany
Kobayashi Y,Suzuki K, Sakurai D, Ohashi-doi K, Nakao A:Cha o 3 may not be a major allergen in Japanese cypress pollinosis. EAACI Hybrid Congress 2023 2023年6月9-11日 Hamburg, Germany
Nakamura Y, Nakao A:MOD000001, a Novel Highly Selective and Orally Available KIT Inhibitor, Suppresses Passive Cutaneous Anaphylactic (PCA) Reaction and Food Allergy in Mice. 2023 AAAAI Annual Meeting 2023年2月24-27日 San Antonio, USA
Nakamura Y, Nakao A: Regulation of steady state plasma histamine levels by the mast cell clock. 2018 SRBR Meeting 2018年5月12-16日 Florida, USA
Thu Le HP,Nakao A: The frequency of Th17 cells in The small intestine
exhibits a day-night variation dependent on circadian clock activity. 2018
SRBR Meeting 2018年5月12-16日 Florida, USA
Nakamura Y, Nakao A:Circadian regulation of allergy. The 95th Annulal Meeting
of Physiological Society of Japan 2018年3月28-30日 香川
Nakamura Y, Nakao A, Shibata S: Inhibition of IgE-mediates allergic reaction by pharmacologically
targeting the circadian clock. 第45回日本免疫学会学術集会 2016年12月5-7日 沖縄
Oh-oka K, Nakao A: 5-amino salicylic acid (5-ASA) induces the colonic regulatory Tcells via the activation of the aryl hydrocarbon receptor signaling pathway. 第45回日本免疫学会学術集会 2016年12月5-7日 沖縄
Le Pham Thu Ha, Nakamura Y, Nakao A: Migration of Th17 cells to the small
intestine is temporally regulated by the circadian clock. 第45回日本免疫学会学術集会 2016年12月5-7日
沖縄
中村勇規, 柴田重信, 中尾篤人:Regulation of plasma histamine levels by the mast cell clock and its modulation
by stress. 第23回日本時間生物学会学術大会 2016年11月12-13日 名古屋
Ihara T, Kira S, Miyamoto T, Sawada N, Nakagomi H, Mitsui T, Kobayashi
H, Yoshiyama M, Takeda M, Nakamura Y, Nakao A, Shigetomi E, Shibata K, Shinozaki Y, Koizumi S: Clock genes regulate
the circadian rhythm of Piezo1 and TRPV4 expressions and intracellular
Ca2+ influx after stretch stimulation in cultured urothelial cells. 31th
Annual Congress of the European Association of Urology Abstracts 2016年3月11-15日
Munich, Germany
Nakamura Y, Shibata S, Nakao A:Inhibition of IgE-Mediated Allergic Reaction By Pharmacologically Targeting
the Circadian Clock. 2016 AAAAI Annual Meeting 2016年3月4-7日 Los Angeles
Oh-oka K, Nakao A: Circadian clock regulates the expression levels of tight junction proteins,
permeability, and barrier function in the intestine. 第42回日本免疫学会 2013年12月11-13日
千葉
Aihara Y, Oh-oka K, Nakao A, Kondo N, Shrestha S, Shrestha N, Sharma J, Yamagata Z: Colostrum feeding and immunological substance in colostrum among lactating women from urban and rural environments, Nepal. 44th Asia-Pacific Academic Consortium for Public Health. 2012年10月13-18日 Colombo, Sri Lanka
Nakao A:[Symposium:Various research fields can solve the physiological function
of biological clocks] Circadian clock gene Period2 regulates a time-of-day-dependent
variation in cutaneous anaphylactic reaction. 第89回日本生理学会 2012年3月29-31日
松本
Nakao A:The biological clock regulates allergic reaction. The 1st University of Yamanashi Global COE Meeting 2011 2011年9月6日 山梨
Oh-oka K,Nakao A: Dysfunction of the circadian gene Period2 protects mice against DSS-induced colitis. -Period2 regulates intestinal barrier function- 15th International Congress of Mucosal Immunology. 2011年7月5日-7月9日 Paris, France
Nakao A:Activation of aryl hydrocarbon receptor ameliorates experimental colitis in mice. The 2nd University of Yamanashi Global COE Meeting 2009 2010年1月29日 山梨
Nakao A:Cigarette smoke extract induces TSLP expression, leading to Th2-type immune responses and airway inflammation. University of Yamanashi Global COE program International Symposium 2009年1月28-29日 山梨
Shimokawa N, Nishiyama C, Nakao A, Okumura K, Ogawa H:Role of a transcription factor GATA-1 in commitment between dentritic cells and mast cells. 第38回日本免疫学会総会 2008年12月1-3日 京都
Nakamura Y, Miyata M, Shimokawa N, Ogawa H, Nakao A:Cigarette smoke extract induce TSLP expression ,leading to allergic airway inflammation. 第58回日本アレルギー学会秋季学術大会 2008年11月27-29日 東京都
Nakao A:Orally administered TGF-βis biologically active in the intestinal mucosa and enhances oral tolerance. Second Japanese-French Frontiers of Science Symposium. Jan 25-27,2008, Roscoff, France
Nakao A, Ando T, Hatsushika K, Wako M, Ohnuma Y, Ogawa H, Okumura K, Wyss-Coray T:Orally administered TGF-β is biologically active in the intestinal mucosa and enhances oral tolerance. 13th International Congress of Mucosal Immunology July 9-12, 2007 Tokyo
Nakao A:Suppression of serum IgE response and systemic anaphylaxis in a food allergy model by orally administered high-dose TGF-β. KEYSTONE SYMPOSIA Allergy, Allergic Inflammation and Asthma April 6-11, Colorado, USA
Kobayashi Y, Sakai K, Nguyen Quoc Vuong Tran, Ishimaru K, Sato T, Nakamura Y, Nakagomi D, Tanaka S, Koizumi S, Nakoa A: IL-33 sensitizes mast cells to Piezo1 stimulation leading to degranulation. Allergy 79(12):3517-3520, 2024
Nguyen Quoc Vuong Tran, Kobayashi Y, Nakamura Y, Ishimaru K, Izuhara K, Nakao A: Transcriptomic Evidence for T Cell-Fibroblast-Keratinocyte Axis via IL-13-Periostin-Integrin in Atopic Dermatitis Allergy 79(12):3521-3525, 2024
Minh-Khang Le, Nguyen Quoc Vuong Tran, Phuc-Tan Nguyen, Thuy-An Nguyen, Nakao A, Kondo T: Comprehensive analysis of distinct circadian clock subtypes of adult diffuse glioma and their associations with clinicopathological, genetic, and epigenetic profiles Journal of Neuropathology & Experimental Neurology 83(9):736-744, 2024
Nguyen Quoc Vuong Tran, Minh Khang Le, Nakamura Y, Nakao A: Severe asthmatic airways have distinct circadian clock gene expression pattern associated with WNT signaling Clinical and Translational Allergy 2024 Jul;14(7):e12379
Nakamura Y, Urakami T, Ishimaru K, Nguyen Quoc Vuong Tran, Shimizu T, William, Sinko, Takahashi T, Sivapriya Marappan, Kishore Narayanan, Ramulu Poddutoori, Terada Y, Nakao A: A highly selective KIT inhibitor MOD000001 suppresses IgE-mediated mast cell activation Journal of Allergy and Clinical Immunology: Global 3(3):100249, 2024
1994
Nakajima H, Nakao A, Watanabe Y, Yoshida S, Iwamoto I: IFN-α inhibits antigen-induced eosinophil and CD4 T cell recruitment into tissue. J Immunol 153:1264-1270, 1994
Nakao A, Nakajima H, Tomioka H, Nishimura T, Iwamoto I: Induction of T cell tolerance by pretreatment with anti-ICAM-1 and ant-LFA-1 antibodies prevents antigen-induced eosinophil recruitment into the mouse airways. J Immunol 153:5819-5825, 1994
2000
Mamura M, Nakao A, Goto D, Kato M, Saito Y, Iwamoto I: Ligation of the T cell receptor complex results in phosphorylation of Smad2 in T lymphocytes. Biochem Biophys Res Commun 268:124-127, 2000.
Umibe T, Kita Y, Nakao A, Nakajima H, Fukuda T, Yoshida S, Sakamaki T, Saito Y, Iwamoto I: Clonal expansion of T cells infilatrating in the airways of non-atopic asthmatics. Clin Exp Immunol 119:390-397, 2000.
Oishi Y, Sakamoto A, Kurasawa K, Nakajima H, Nakao A, Nakagawa N, Tanabe E, Saito Y, Iwamoto I: CD4-CD8-T cells bearing invariant Vα24JαQ TCR α-chain are decreased in patients with atopic diseases. Clin Exp Immunol 119:404-411, 2000.
Kumano K, Nakao A, Nakajima H, Miike S, Kurasawa K, Saito Y, Iwamoto I: Blockade of JAK2 by tyrphostin AG-490 inhibits antigen-induced eosinophil recruitment into the mouse airways. Biochem Biophys Res Commun 270:209-214, 2000.
Nakajima H, Nakao A, Kumano K, Yamamoto H, Iwamoto I: Systemic T helper 2 cell activation is not sufficient for antigen-induced eosinophil recruitment into the airways. Int Arch Allergy Immunol 122 (S1):20-24, 2000.
Nakao A, Miike S, Hatano M, Okumura K, Tokuhisa T, Ra C, Iwamoto I: Blockade of TGF-β/Smad signaling by overexpression of Smad7 in T cells enhances antigen-induced airway inflammation and airway reactivity. J Exp Med 192:151-158, 2000.
Aihara Y, Oh-oka K, Kondo N, Ishimaru K, Hara M, Yamagata Z, Nakao A: Comparison of colostrum TGF-β2 levels between lactating women in Japan and Nepal. Asian Pacific Journal of Allergy and Immunology 32(2)178-184, 2014
Fukumoto S, Toshimitsu T, Matsuoka S, Maruyama A, Oh-oka K, Takamura T, Nakamura Y, Ishimaru K, Fujii-Kuriyama Y, Ikegami S, Itou H, Nakao A:Identification of a probiotic bacteria-derived activator of the aryl hydrocarbon receptor that inhibits colitis. Immunology and Cell Biology 92(5)460-465, 2014
Oh-oka K, Kono H, Ishimaru K, Miyake K, Kubota T, Ogawa H, Okumura K, shibata S, Nakao A: Expressions of tight junction proteins Occludin and Claudin-1 are under the circadian control in the mouse large intestine: implications in intestinal permeability and susceptibility to colitis.PLoS One 9(5)e98016, 2014
Nakamura Y, Ishimaru K, Tahara Y, Shibata S, Nakao A: Disruption of the Suprachiasmatic Nucleus Blunts A Time of Day-Dependent Variation in Systemic Anaphylactic Reaction in Mice. Journal of Immunology Research vol.2014 Article ID474217, 2014
Nakao A: Temporal regulation of cytokines by the circadian clock. [Review] Journal of Immunology Research vol.2014 Article ID 614529, 2014
Aihara Y, Oh-oka K, Kondo N, Sharma J, Shrestha N, Ishimaru K, Hara M, Yamagata Z, Nakao A: Residential area, birth order, and dietary habit may influence TSLP levels in colostrum: Comparative study between Japan and Nepal. Allergology International 63(2)283-285, 2014
Nakamura Y, Nakano N, Ishimaru K, Hara M, Ikegami T, Tahara Y, Katoh R, Ogawa H, Okumura K, Shibata S, Nishiyama C, and Nakao A: Circadian regulation of allergic reaction by the mast cell clock in mice.J Allergy Clin Immun 133(2)568-575.e12, 2014
2014
2015
Tanabe K, Kitagawa E, Wada M, Haraguchi A, Orihara K, Tahara Y, Nakao A, and Shibata S: Antigen exposure in the late light period induces severe symptoms of food allergy in an OVA-allergic mouse model. Scientific Reports 5 Article number:14424, 2015
Ando N, Nakamura Y, Aoki R, Ishimaru K, Ogawa H, Okumura K, Shibata S, Shimada S, Nakao A: Circadian Gene Clock Regulates Psoriasis-like Skin Inflammation in Mice. Journal of Investigative Dermatology 135:3001-3008, 2015
Nakao A: IL-7:AhR We Ready for a New Cytokine to Fight Colitis? [Editorial] Dig Dis Sci 60(7)1876-1877, 2015
Koyama K, Ohba T, Haro H, and Nakao A: Positive Association of Serum Thymic Stromal Lymphopoietin with Anti-Citrullinated Peptide Antibody in Rheumatoid Arthritis. Clnical Experimental Immunology 181(2)239-243, 2015
Nakao A, Nakamura Y, and Shibata S: The Circadian Clock Functions As A Potent Regulator of Allergic Reaction. [Review] Allergy 70(5)467-473, 2015
Ando N, Nakamura Y, Ishimaru K, Ogawa H, Okumura K, Shimada S, and Nakao A: Allergen-specific basophil reactivity exhibits daily variations in seasonal allergic rhinitis. Allergy 70(3)319-322, 2015
Igarashi S, Suzuki K, Nakamura Y, Ishimaru K, Fukano C, Masuyama K, Ohashi-Doi K, Nakao A: The efficacy of sublingual immunotherapy for allergic rhinitis may vary with the time of day. Int Arch Allergy Immunol 171(2)111-118, 2016
Hanihara M, Kawataki T, Oh-oka K, Mitsuka K, Nakao A, and Kinouchi H: Synergistic anti-tumor effect with indoleamine 2,3-dioxygenase inhibition and temozolomide in a murine glioma model. Journal of Neurosurgery 124(6)1594-1601, 2016
Nakamura Y, Nakano N, Ishimaru K, Ando N, Katoh R, Suzuki-Inoue K, Koyanagki S, Ogawa H, Okumura K, Shibata S, Nakao A: Inhibition of IgE-mediated allergic reaction by pharmacologically targeting the circadian clock. J Allergy Clin Immun 137(4)1226-1235, 2016
Aoki R, Kawamura T, Goshima F, Ogawa Y, Nakae S, Moriishi K, Nakao A, Shimada S: The alarmin IL-33 derived from HSV-2-infected keratinocytes triggers mast cell-mediated antiviral innate immunity. J Invest Dermatol 136(6)1290-1292, 2016
Matsuoka S, Ishii Y, Nakao A, Abe M, Ohtsuji N, Momose S, Jin H, Arase H, Sugimoto K, Nakauchi Y, Masutani H, Maeda M, Yagita H, Komatsu N, Hino O: Establishment of a therapeutic anti-pan HLA-class Ⅱ monoclonal antibody that directly induces lymphoma cell death via large pore formation. PLoS One 11(3):e0150496, 2016
2016
2021
Takahashi T, Fukudome H, Ueno HM, Watanabe-Matsuhashi S, Nakano T, Kobayashi
T, Ishimaru K, Nakao A: Probiotic Supplementation and Human Milk Cytokine
Profiles in Japanese Women: A Retrospective Study from an Open-Label Pilot
Study. Nutrients 13(7):2285, 2021
1995
Iwamoto I, Nakao A: Induction of Th2 cell tolerance to a soluble antigen by blockade of the LFA-1-dependent pathway prevents allergic inflammation. Immunol Res 14: 263-270, 1995.
1997
Nakao A, Roijer E, Imamura T, Souchelnytskyi S, Stenman G, Heldin CH, ten Dijke P: Identification of Smad2, a human Mad-related protein in the TGF-β signaling pathway. J Biol Chem 272:2896-2900, 1997
Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Ishisaki A, Oeda E, Tamaki K, Hanai J, Heldin CH, Miyazono K, ten Dijke P: TGF-β receptor mediated signaling through Smad2, Smad3, and Smad4. EMBO J 16:5353-5362, 1997
Nakao A, Afrakhte M, Moren A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin NE, Heldin CH, ten Dijke P: Identification of Smad7, a TGF-β-inducible antagonist of TGF-β signaling. Nature 389:631-635, 1997
1998
Nakao A, Kasai M, Kumano K, Nakajima H, Kurasawa K, Iwamoto I: High-dose oral tolerance prevents antigen-induced eosinophil recruitment into the mouse airways. Int Immunol 10:387-394, 1998
Shimizu A, Kato M, Nakao A, Imamua T, ten Dijke P, Heldin CH, Kawabata M, Shimada S, Miyazono K: Identification of receptors and Smad proteins involved in activin signaling in a human epidermal keratinocyte cell line. Genes to Cells 3:125-134, 1998
Ishisaki A, Yamato K, Nakao A, Nonaka K, Ohguchi M, ten Dijke P, Nishihara T: Smad7 is an activin-responsive gene inhibiting activin-signals for growth arrest and apoptosis. J Biol Chem 273:24293-24296, 1998
Souchelnytskyi S, Nakayama T, Nakao A, Moren A, Heldin CH, Christian JL, ten Dijke P: Physical and functional interaction of mouse Smad7 and xenopus Smad8 with bone morphogenetic protein receptors and transforming growth factor-β receptors. J Biol Chem 273: 25364-25370, 1998
Kasai M, Kumano K, Kurasawa K, Nakao A, Saito Y, Iwamoto I: Blockade of CD28/B7 interaction suppresses allergic eosinophilic inflammation in mice. Int Arch Allergy Immunol 117(S1):14-19, 1998
Tamaki K, Souchelnytskyi S, Itoh S, Nakao A, Sampath K, Heldin CH, ten Dijke P: Intracellular signaling of osteogenic protein-1 through Smad5 activation. J Cell Physiol 177:355-363, 1998
1999
Miike S, Nakao A, Hiraguri M, Kurasawa K, Saito Y, Iwamoto I: Involvement of Jak2, but not PI3-kinase/Akt and MAP kinase pathways, in anti-apoptotic signals of GM-CSF in human eosinophils. J Leuk Biol 65:700-706, 1999
Ishisaki A, Yamato K, Hashimoto S, Nakao A, Tamaki K, Nonaka K, ten Dijke P, Sugino H, Nishihara T: Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth and apoptosis in B cells. J Biol Chem 274:13637-13642, 1999
Nakao A, Fujii M, Matsumura R, Kumano K, Saito Y, Miyazono K, Iwamoto I: Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice. J Clin Invest 104:5-11, 1999
Heldin NE, Bergstrom D, Hermansson A, Bergenstrahle A, Nakao A, Westermark B, ten Dijke P: Lack of responsiveness to TGF-β1 in a thyroid carcinoma cell line with functional type I and type II receptors and Smad proteins, suggests a novel mechanism of TGF-β insensitivity in carcinoma cells. Mol Cell Endocrinol 153:79-90, 1999
Kumano K, Nakao A, Nakajima H, Hayashi F, Kurimoto M, Okamura H, Saito Y, Iwamoto I: IL-18 enhances antigen-induced eosinophil recruitment into the mouse airways. Am J Resp Crit Care Med 160:873-878, 1999
Tsukahara K, Nakao A, Hiraguri M, Miike S, Saito Y, Iwamoto I: TNF-α mediates anti-apoptotic signals via P38 MAP kinase activation in human eosinophils. Int Arch Allergy Immunol 120(S):54-59, 1999.
2001
Inagaki Y, Mamura M, Kanamaru Y, Greenwell P, Takehara K, ten Dijke P, Nakao A: Constitutive phosphorylation and nuclear localization of Smad3 correlate to increased collagen gene transcription in activated hepatic stellate cells. J Cell Physiol 187:117-123, 2001
Inagaki Y, Nemoto T, Nakao A, ten Dijke P, Kobayashi K, Takehara K, Greenwel P: Interaction between GC box binding factors and Smad proteins modulates cell lineage-specific α2(I) collagen gene transcription. J Biol Chem 276:16573-16579, 2001
Kanamaru Y, Nakao A, Mamura M, Suzuki Y, Shirato I, Okumura K, Tomino Y, Ra C: Blockade of TGF-β signaling in T cells prevents the development of experimental glomerulonephritis. J Immunol 166:2818-2823, 2001
Hira K, Mitsuishi K, Kawamoto K, Suto H, Nakao A, Ra C, Ogawa H:Establishment and characterization of a murine mast cell line derived from NC/Nga mice. Int Arch Allergy Clin Immunol 125 (S1):67-70, 2001
Okazaki T, Nakao A, Nakano H, Takeda K, Shimozato O, Takahashi F, Takahashi K, Yagita H, Okumura K: Impairment of bleomycin-induced lung fibrosis in CD28-deficient mice. J Immunol 167:1977-1981, 2001
Supajatura S, Ushio H, Nakao A, Okumura K, Ra C, Ogawa H: Protective roles of mast cells against enterobacterial infection are mediated by Toll-like receptor 4. J Immunol 167:2250-2256, 2001
Uchida T, Nakao A, Nakano N, Kuramasu A, Saito H, Okumura K, Ra C, Ogawa H: Identification of NASH1, a novel protein containing a nuclear localization signal, a sterile a motif, and a SH3 domain preferentially expressed in mast cells. Biochem Biophys Res Commun 288:137-141, 2001
Palungwachira P, Chirachanakul P, Palungwachira P, Chalugun P, Nakao A, Takamori K, Ogawa H: Cutaneous findings in HIV-1-positive patients in Thailand. The Journal of Dermatology 10:584-585, 2001
Nakao A: Is transforming growth factor-β1 the key to suppression of human asthma? [Review] Trends Immunol (Formerly; Immunol. Today) 22:115-118, 2001
Nakao A: The TGF-β1 paradox in asthma. [Correwpondence] Trends Immunol (Formerly; Immunol. Today) 22:300, 2001
2002
Sumiyoshi K, Nakao A, Ushio H, Mitsuishi K, Okumura K, Tsuboi R, Ra C, Ogawa H: TGF-β1 suppresses atopic dermatitis-like skin lesions in NC/Nga mice. Clin Exp Allergy 32:309-314, 2002
Suzuki R, Nakao A, Kanamaru Y, Okumura K, Ogawa H, Ra C: Localization of intestinal intraepithelial T lymphocytes involves regulation of αEβ7 expression by TGF-β. Int Immunol 14:339-345, 2002
Terada Y, Hanada S, Nakao A, Kuwahara M, Sasaki S, Marumo F: Gene transfer of Smad7 using electroporation of adenovirus prevents renal fibrosis in post-obstructed kidney. Kidney Int 61 (sym.1):S94-S98, 2002
Supajatura V, Ushio H, Nakao A, Akira S, Okumura K, Ra C, Ogawa H: Toll-like receptor 2 and 4 of mast cells have different functional responses in allergy and innate immunity. J Clin Invest 109:1351-1359, 2002
Kanamaru Y, Nakao A, Shirato I, Okumura K, Ogawa H, Tomino Y, Ra C: Chronic graft-versus-host autoimmune disease in Fc receptorγchain-deficient mice results in lipoprotein glomerulopathy. J Am Soc Nephrol 13:1527-1533, 2002
Sagara H, Okada T, Okumura K, Ogawa H, Ra C, Fukuda T, Nakao A: Activation of TGF-β/Smad2 signaling is associated with airway remodeling in asthma. J Allergy Clin Immunol 110:249-254, 2002
Kanamaru Y, Nakao A, Ra C, Okumura K, Muso E, Ogawa H, Kobayashi I, Horikoshi S, Tomino Y: Role of transforming growth factor-β/Smad signaling pathway in enhanced production of glomerular extracellular matrix in IgA nephropathy of high-serum IgA ddY mice. Nephrology 7:S151-155, 2002
Okado T, Terada Y, Tanaka H, Inoshita S, Nakao A, Sasaki S: Smad7 mediates transforming growth factor-β-induced apoptosis in mesangial cells. Kidney Int 62:1178-1186, 2002.
Nakao A, Sagara H, Setoguchi Y, Okada T, Okumura K, Ogawa H, Fukuda T: Expression of Smad7 in bronchial epithelial cells is inversely correlated to basement membrane thickness and airway hyperresponsiveness in patients with asthma. J Allergy Clin Immunol 110:873-878, 2002.
Nakao A, Okumura K, Ogawa H: Smad7: a new key player in TGF-β-associated disease. [Review] Trends Mol Med (Formerly; Mol. Med. Today) 8:361-363, 2002
Inagaki Y, Nemoto T, Nakao A: Transcriptional regulation of type I collagen gene expression by transforming growth factor-β/Smad signaling and its antagonistic factors. Connective Tissue 34:139-146, 2002
2003
Higashi K, Inagaki Y, Fujimori K, Nakao A, Kaneko H, Nakatsuka I: IFN-γ interferes with transforming growth factor-β signaling through direct interaction of YB-1 with Smad3. J Biol Chem 278:43470-43479, 2003
Inagaki Y, Nemoto T, Kushida M, Sheng Y, Higashi K, Ikeda K, Kawada N, Shirasaki F, Takehara K, Sugiyama K, Fujii M, Yamauchi H, Nakao A, De Crombrugghe B, Watanabe T, Okazaki I: Interferon-α down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice. Hepatology 38:890-899, 2003
Sumiyoshi K, Nakao A, Setoguchi Y, Okumura K, Tsuboi R, Ogawa H: Smads regulate collagen gel contraction by human dermal fibroblasts. Br J Dermatol 149:464-70, 2003
Wongpiyabovorn J, Suto H, Ushio H, Izuhara K, Mitsuishi K, Ikeda S, Nakao A, Okumura K, Ogawa H: Up-regulation of interleukin-13 receptor α1 on human keratinocytes in the skin of psoriasis and atopic dermatitis. J Dermatol Sci 33:31-40, 2003
Kanamaru Y, Nakao A, Tanaka Y, Inagaki Y, Ushio H, Shirato I, Horikoshi S, Okumura K, Ogawa H, Tomino Y. Involvement of p300 in TGF-β/Smad-pathway-mediatedα2(I) collagen expression in mouse mesangial cells. Nephron Exp Nephrol 95:e36-42, 2003
Ogihara T, Watada H, Kanno R, Ikeda F, Nomiyama T, Tanaka Y, Nakao A, German MS, Kojima I, Kawamori R: p38 mitogen-activated protein kinase is involved in activin A- and HGF-mediated expression of pro-endocrine gene neurogenin3 in AR42J-B13 cells. J Biol Chem 278:21693-21700, 2003
Hasegawa T, Nakao A, Sumiyoshi K, Tsuboi R, Ogawa H: IFN-γ fails to antagonize fibrotic effect of TGF-β on keloid-derived dermal fibroblasts. J Dermatol Sci 32:19-24, 2003
Sumiyoshi K, Nakao A, Setoguchi Y, Tsuboi R, Okumura K, Ogawa H:TGF-βSmad signaling inhibits IFN-γ and TNF-α-induced TARC (CCL17) production in HaCaT cells. J Dermatol Sci 31:53-8, 2003
Funaki T, Nakao A, Ebihara N, Setoguchi Y, Fukuchi Y, Okumura K, Ra C, Ogawa H, Kanai A: Smad7 suppresses the inhibitory effect of TGF-β2 on corneal endothelial cell proliferation and accelerates corneal endothelial wound closure in vitro. Cornea 22:153-9, 2003
Warnnissorn P, Nakao A, Suto H, Ushio H, Yamaguchi N, Yagita H, Okumura K, Ogawa H: TRAIL expression in atopic dermatitis. Br J Dermatol 148:829-831, 2003
2004
Inazaki K, Kanamaru Y, Kojima Y, Sueyoshi N, Okumura K, Kaneko K, Yamashiro Y, Ogawa H, Nakao A: Smad3 deficiency attenuates renal fibrosis, inflammation, and apoptosis after unilateral ureteral obstruction. Kidney Int 66:597-604, 2004
Sumiyoshi K, Nakao A, Setoguchi Y, Okumura K, Ogawa H: Exogenous Smad3 accelerates wound healing in a rabbit dermal ulcer model. J Invest Dermatol 123:229-236, 2004
Jin L, Nakao A, Nakayama M, Yamaguchi N, Kojima Y, Nakano N, Tsuboi R, Okumura K, Yagita H, Ogawa H: Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes. J Invest Dermatol 122:1175-1179, 2004
Ushio H, Nakao A, Supajatura V, Miyake K, Okumura K, Ogawa H: MD-2 is required for the full responsiveness of mast cells to LPS but not to PGN. Biochem Biophys Res Commun 323:491-498, 2004
Xu H, Okamoto A, Ichikawa J, Ando T, Tasaka K, Masuyama K, Ogawa H, Yagita H, Okumura K, Nakao A: TWEAK/Fn14 interaction stimulates human bronchial epithelial cells to produce IL-8 and GM-CSF. Biochem Biophys Res Commun 318:422-427, 2004
Komine-Kobayashi M, Chou N, Mochizuki H, Nakao A, Mizuno Y, Urabe T: Dual role of Fcγ receptor in transient focal cerebral ischemia in mice. Stroke 35:958-963, 2004
Prapars M, Nakao A, Nakano H, Jin L, Ogawa H: Expression of phosphorylated Smad2 in normal human epidermis. J Dermatol Sci 34:54-55, 2004
Furuse Y, Hashimoto N, Maekawa M, Toyama Y, Nakao A, Iwamoto I, Sakurai K, Suzuki Y, Yagui K, Yuasa S, Toshimori K, Saito Y: Activation of the Smad pathway in glomeruli from a spontaneously diabetic rat model, OLETF rats. Nephron Exp Nephrol 98:100-108, 2004
2005
Kanamaru Y, Sumiyoshi K, Ushio H, Ogawa H, Okumura K, Nakao A:Smad3 deficiency in mast cells provides efficient host protection against acute septic peritonitis. J Immunol 174(7)4193-7, 2005
Okamoto A, Kawamura T, Kanbe K, Kanamaru Y, Ogawa H, Okumura K, Nakao A: Suppression of serum IgE response and systemic anaphylaxis in a food allergy model by orally administered high-dose TGF-β. Int Immunol 17(6)705-712, 2005
Hasegawa T, Nakao A, Sumiyoshi K, Tsuchihashi H, Ogawa H: SB-431542 inhibits TGF-β- induced contraction of collagen gel by normal and keloid fibroblasts. J Dermatol Sci 39(1)33-8, 2005
Mimura K, Kono K, Hanawa M, Kanzaki M, Nakao A, Ooi A, Fujii H:Trastuzumab-mediated antibody-dependent cellular cytotoxicity against esophageal squamous cell carcinoma. Clin Cancer Res 11:4898-904, 2005
Ando T, Ichikawa J, Okamoto A, Tasaka K, Nakao A, Hamada Y:Gemcitabine inhibits viability, and metastasis of Osteosarcoma cell line. J Orthopaedic Research 23(4)964-969, 2005
Nakano N, Nakao A, Ishidoh K, Tsuboi R, Kominami E, Okumura K, Ogawa H: CDK5 regulates cell-cell and cell-matarix adhesion in human keratinocytes. Br J Dermatol 153(1)37-45, 2005
Nakano N, Nakao A, Uchida T, Shirasaka N, Yoshizumi H, Okumura K,Tsuboi R, Ogawa H: Effects of arachidonic acid analogs on FcepsilonRI-mediated activation of mast cells. Biochim Biophys Acta 1738:19-28, 2005
2006
Zhang L, Sato E, Amagasaki K, Nakao A, Naganuma H:Participation of an abnormality in the transforming growth factor-beta signaling pathway in resistance of malignant glioma cells to growth inhibition induced by that factor. J Neurosurg 105(1)119-28, 2006
Ando T, Ichikawa J, Wako M, Hatsushika K, Watanabe Y, Sakuma M, Tasaka K, Ogawa H, Hamada Y, Yagita H, Nakao A:TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in mouse osteoblastic MC3T3-E1 cells. Arthritis Research & Therapy 8(5):R146, 2006
2007
Ozawa T, Koyama K, Ando T, Ohnuma Y, Hatsushika K, Ohba T, Sugiyama H, Hamada Y, Ogawa H, Okumura K, Nakao A:Thymic stromal lymphopoietin secretion of synovial fibroblasts is positively and negatively regulated by Toll-like receptors/nuclear factor-κB pathway and interferon-γ/dexamethasone. Modern Rheumatology 17(6):459-463, 2007
Wako M, Haro H, Ando T, Hatsushika K, Ohba T, Iwabuchi S, Nakao A, Hamada Y: Novel function of TWEAK in inducing intervertebral disc degeneration. J Orthop Res 25(11)1438-1446, 2007
Koyama K, Hatsushika K, Ando T, Sakuma M, Wako M, Kato R, Sugiyama H, Hamada Y, Ogawa H, Nakao A:Imatinib mesylate both prevents and treats the arthritis induced by type II collagen antibody in mice. Modern Rheumatology 17(4):306-310, 2007
Hatsushika K, Hirota T, Harada M, Sakashita M, Kanzaki M, Takano S, Doi S, Fujita K, Enomoto T, Ebisawa M, Yoshihara S, Sagara H, Fukuda T, Masuyama K, Katoh R, Matsumoto K, Saito H, Ogawa H, Tamari M, Nakao A:Transforming Growth Factor-β2 polymorphisms are associated with childhood atopic asthma. Clin Exp Allergy 37(8):1165-74, 2007
Ando T, Hatsushika K, Wako M, Ohba T, Koyama K, Ohnuma Y, Katoh R, Ogawa H, Okumura K, Luo J, Wyss-Coray T, Nakao A:Orally administered TGF-βis biologically active in the intestinal mucosa and enhances oral tolerance. J Allergy Clin Immun 120(4)916-923, 2007.
Hasegawa T, Sumiyoshi K, Tsuchihashi H, Ikeda S, Nakao A, Ogawa H:FK506 inhibits the enhancing effects of TGF-beta on would healing in a rabbit dermal ulcer model. J Dermatol Sci 47(1)37-40, 2007
Koyama K, Ozawa T, Hatsushika K, Ando T, Takano S, Wako M, Suenaga F, Ohnuma Y, Ohba T, Katoh R, Sugiyama H, Hamada Y, Ogawa H, Okumura K, Nakao A:A possible role for TSLP in inflammatory arthritis. Biochem Biophys Res Commun 357(1)99-104, 2007
Takano S, Kanai F, Jazag A, Ijichi H, Yao J, Ogawa H, Enomoto N, Omata M, Nakao A:Smad4 is essential for down-regulation of E-cadherin induced by TGF-β in pancreatic cancer cell line PANC-1. J Biochem(Tokyo) 141(3)345-351, 2007
Sakuma M, Hatsushika K, Koyama K, Katoh R, Ando T, Watanabe Y, Wako M, Kanzaki M, Takano S, Sugiyama H, Hamada Y, Ogawa H, Okumura K, Nakao A:TGF-β type I receptor kinase inhibitor down-regulates rheumatoid synoviocytes and prevents the arthritis induced by type II collagen antibody. Int Immunol 19(2)117-26, 2007
Tsuchihashi H, Hasegawa T, Sumiyoshi K, Ikeda S, Ando T, Nakao A, Okumura K, Ogawa H:TWEAK inhibits TGF-β-induced contraction of normal and keloid fibroblast-embedded collagen gel. J Dermatol Sci 45(3):216-8, 2007
Kanzaki M, Shibagaki N, Hatsushika K, Mitsui H, Inozume T, Okamoto A, Dobashi Y, Ogawa H, Shimada S, Nakao A:Human eosinophils have an intact Smad signaling pathway leading to a major TGF-beta target gene expression. Int Arch Allergy Imm 142(4)309-317, 2007
2008
Nakamura Y, Miyata M, Ohba T, Ando T, Hatsushika K, Suenaga F, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Nakao A: Cigarette smoke extract induces thymic stromal lymphopoietin expression, leading to TH2-type immune responses and airway inflammation. J Allergy Clin Immun 122(6)1208-1214, 2008
Funaki T, Ebihara N, Murakami A, Nakao A: Ex vivo transfer of Smad7 decreases damage to the corneal endothelium after penetrating keratoplasty. Jpn J Ophthalmol 52:204-210, 2008
Wako M, Ohba T, Ando T, Arai Y, Koyama K, Hamada Y, Nakao A, Haro H:Mechanism of signal transduction in TWEAK-induced matrix degradation by MMP-3 up-regulation in disc tissues. Spine 33(23)2489-2494, 2008
Takano S, Ando T, Hiramatsu N, Kanayama A, Maekawa S, Ohnuma Y, Enomoto N, Ogawa H, Paton AW, Paton JC, Kitamura M, Nakao A: T cell receptor-mediated signaling induces GRP78 expression in T cells: The implications in maintaining T cell viability. Biochem Biophys Res Commun 371(4)762-766, 2008
Ohba T, Haro H, Ando T, Koyama K, Hatsushika K, Suenaga F, Ohnuma Y, Nakamura Y, Katoh R, Ogawa H, Hamada Y, Nakao A:A potential role of TSLP in the recruitment of macrophages to the intervertebral disc via MCP-1 induction:The implications in a herniated disc. Arthritis and Rheumatism 58(11)3510-3519, 2008
Miyata M, Hatsushika K, Ando T, Shimokawa N, Ohnuma Y, Katoh R, Suto H, Ogawa H, Masuyama K, Nakao A:Mast cell regulation of epithelial TSLP expression plays an important role in the development of allergic rhinitis. Eur J Immunol 38(6)1487-1492, 2008
Suenaga F, Hatsushika K, Takano S, Ando T, Ohnuma Y, Ogawa H, Nakao A:A possible link between resveratrol and TGF-β: resveratrol induction of TGF-β expression and signaling. FEBS Letters 582(5)586-590, 2008
2009
Miyata M, Nakamura Y, Shimokawa N, Ohnuma Y, Katoh R, Matsuoka S, Okumura
K, Ogawa H, Masuyama K, Nakao A: Thymic stromal lymphopoietin is a critical mediator of IL-13-driven allergic
inflammation. Eur J Immunol 39(11) 3078-3083, 2009
Nakamura Y, Miyata M, Ando T, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Okumura K, Nakao A: The latent form of transforming growth factor-β administered orally is activated by gastric acid in mice. J Nutr 139(8)1463-1468, 2009
Nakamura Y, Miyata M, Shimokawa N,Ohnuma Y, Katoh R, Ogawa H, Okumura K, Nakao A: House dust mite allergen Der f 1 can induce the activation of latent TGFβ via its protease activity. FEBS Letters 583(12)2088-2092, 2009
Harama D, Koyama K, Mukai M,Shimokawa N, Miyata M, Nakamura Y, Ohnuma Y, Ogawa H, Matsuoka S, Paton AW, Paton JC, Kitamura M, Nakao A: A sub-cytotoxic dose of subtilase cytotoxin prevents LPS-induced inflammatory responses, depending on its capacity to induce the unfolded protein response. J Immunol 183(2)1368-1374, 2009
Ohba T, Haro H, Ando T, Wako M, Suenaga F, Aso Y, Koyama K, Hamada Y, Nakao A:TNF-α-induced NK-κB signaling reverses age-related declines in VEGF induction and angiogenic activity in intervertebral disc tissues. J Orthop Res 27(2)229-235, 2009
Ozawa T, Miyata M, Nishimura M, Ando T, Ouyang Y, Ohba T, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Nakao A:Transforming growth factor-β activity in commercially available pasteurized cow milk provides protection against inflammation in mice. J Nutr 139(1):69-75, 2009
2010
Fukunishi N, Katoh I, Tomimori Y, Tsukinoki K, Hata R, Nakao A, Ikawa Y, Kurata S:Induction of ΔNp63 by the newly identified keratinocyte-specific TGF-β signaling pathway with Smad2 and IKKα in squamous cell carcinoma. Neoplasia 12(12)969-979, 2010
Shimokawa N, Nishiyama C, Nakano N, Maeda K, Suzuki R, Hara M, Tokura T, Miyajima H, Nakao A, Ogawa H, Okumura K:Suppressive effects of transcription factor GATA-1 on cell type-specific gene expression in dendritic cells. Immunogenetics 62(7)421-429, 2010
Takamura T, Harama D, Matsuoka S, Shimokawa N, Nakamura Y, Okumura K, Ogawa H, Kitamura M, Nakao A: Activation of the aryl hydrocarbon receptor pathway may ameliorate dextran sodium sulfate-induced colitis in mice. Immunology and Cell Biology 88(6)685-689, 2010
Ouyang Y, Miyata M, Hatsushika K, Ohnuma O, Katoh R, Ogawa H, Okumura K , Masuyama K, Nakao A: TGF-β signaling may play a role in the development of goblet cell hyperplasia in a mouse model of allergic rhinitis. Allergology International 59(3)313-319, 2010
Nakao A:The role and potential use of oral TGF-β in the prevention of infant allergy.
[Review] Clinical & Experimental Allergy 40:725-730, 2010
2011
Ouyang Y, Nakao A, Fan E, Li Y, Zhao L, Zhang W, Han D, Zhang L: Decreased expression of EBI3 and Foxp3 in CD4+CD25+ regulatory T cells in murine experimental allergic rhinitis. ORL Otorhinolaryngol Relat Spec 73(6)313-320, 2011
Fujita K, Ando T, Ohba T, Wako M, Sato N, Nakamura Y, Ohnuma Y, Hara Y, Kato R, Nakao A, Haro H:Age-related expression of MCP-1 and MMP-3 in mouse intervertebral disc in relation to TWEAK and TNF-α stimulation. J Orthop Res 30(4)599-605, 2011
Kondo N, Suda Y, Nakao A, Oh-oka K, Suzuki K, Ishimaru K, Sato M, Tanaka T, Nagai A, Yamagata Z: Maternal psychosocial factors determining the concentrations of transforming growth factor-beta in breast milk. Pediatr Allergy Immunol 22(8)853-861, 2011
Kawamura T, Ogawa Y, Shimozato O, Ando T, Nakao A, Kobata T, Okumura K, Yagita H, Shimada S: CD70 is selectively expressed on Th1 but not on Th2 cells and is required for Th1-type immune responses. J Invest Dermatol 131(6)1251-1261, 2011
Nakamura Y, Harama D, Shimokawa N, Hara M, Suzuki R, Tahara Y, Ishimaru K, Katoh R, Okumura K, Ogawa H, Shibata S, Nakao A: Circadian clock gene Period2 regulates a time-of-day-dependent variation in cutaneous anaphylactic reaction. J Allergy Clin Immun 127(4)1038-1045, 2011
Takamura T, Harama D, Fukumoto S, Nakamura Y, Shimokawa N, Ishimaru K, Ikegami S, Makino S, Kitamura M, Nakao A: Lactobacillus bulgaricus OLL1181 activates the aryl hydrocarbon receptor pathway and inhibits colitis. Immunology and Cell Biology 89(7)817-822, 2011
Sugiyama T, Kitamura M, Sugita K, Hisamoto M, Okuda T, Nakao A: Grape seed extract from "Koshu" cultivar antagonizes dioxin-induced aryl hydrocarbon receptor activation. Am J Enol Viticult 64(1)146-151, 2013
Okada Y, Oh-oka K, Nakamura Y, Ishimaru K, Matsuoka S, Okumura K, Ogawa H, Hisamoto M, Okuda T, Nakao A: Dietary resveratrol prevents the development of food allergy in mice. PLoS One 7(9)e44338, 2012
Kawamura T, Ogawa Y, Nakamura Y, Nakamizo S, Ohta T, Nakano H, Kabashima K, Katayama I, Koizumi S, Kodama T, Nakao A, Shimada S: Severe dermatitis with loss of epidermal langerhans cells in human and mouse zinc deficiency. J Clin Invest 122(2)722-732, 2012
Ouyang Y, Nakao A, Han D, Zhang L: Transforming growth factor-β(1) promotes nasal mucosal mast cell chemotaxis in murine experimental allergic rhinitis. ORL J Otorhinolaryngol Relat Spec 74(3)117-123, 2012
2012
Aoki R, Kawamura T, Goshima F, Ogawa Y, Nakaw S, Nakao A, Moriishi K, Nishiyama Y, Shimada S: Mast cells play a key role in host defense against herpes simplex virus infection through TNF-α and IL-6 production.J Invest Dermatol 133(9)2170-2179, 2013
Cermakian N, Lange T, Golombek D, Sarkar D, Nakao A, Shibata S, Mazzoccoli G: Cross-talk between the circadian clock circuitry and the immune system.[Review] Chronobiol Int 30(7)870-888, 2013
Zhu Y, Ohba T, Ando T, Fujita K, Koyama K, Nakamura Y, Katoh R, Haro H, Nakao A: Endogenous TGF-β activity limits TSLP expression in the intervertebral disc tissue by suppressing NF-κB activation. J Orthop Res 31(7)1144-1149, 2013
Takita E, Yokota S, Tahara Y, Hirao A, Aoki N, Nakamura Y, Nakao A, Shibata S: Biological clock dysfunction exacerbates contact hypersensitivity in mice. Brit J Dermatol 168(1)39-46, 2013
2013
Yamamoto T, Koizumi S, Masuyama K, Nakao A: Regulation of TSLP Expression in Human Lung Fibroblasts:The Involvement of TNF-α TGF-β , FGF-2, and ATP Yamanashi Med 32(1)15-25, 2017
Wada M, Orihara K, Kamagata M, Hama K, Sasaki H, Haraguchi A, Miyakawa H, Nakao A, Shibata S: Circadian clock-dependent increase in salivary IgA secretion modulated by sympathetic receptor activation in mice. Scientific Reports 7 Article number:8802, 2017
Thu Le HP, Nakamura Y, Oh-oka K, Ishimaru K, Nakajima S, Nakao A: The frequency of Th17 cells in the small intestine exhibits a dayenight variation dependent on circadian clock activity. Biochem Biophys Res Commun 490(2)290-295, 2017
Ihara T, Mitsui T, Kira S, Miyamoto T, Sawada N, Nakagomi H, Yoshiyama M, Takeda M, Nakamura Y, Nakao A, Shinozaki Y, Koizumi S: The Clock mutant mouse is a novel experimental model for nocturia and nocturnal polyuria. Neurourology and Urodynamics 36(4)1034-1038, 2017
Oh-oka K, Kojima Y, Uchida K, Yoda M, Ishimaru K, Nakajima S, Hemmi J, Kano H, Fujii-Kuriyama Y, Katoh R, Ito H, Nakao A: Induction of colonic regulatory T cells by 5-aminosalicylic acid (5-ASA) by activating the aryl hydrocarbon receptor. Cell Mol Gastroenterol Hepatol 4(1)135-151, 2017
Kawauchi T, Ishimaru K, Nakamura Y, Nakano N, Hara M, Ogawa H, Okumura K, Shibata S, Nakao A: Clock-dependent temporal regulation of IL-33/ST2-mediated mast cell response. Allergology International 66(3)472-478, 2017
Nakamura Y, Ishimaru K, Shibata S, Nakao A: Regulation of plasma histamine levels by the mast cell clock and its modulation by stress. Scientific Reports 7 Article number:39934, 2017
Ihara T, Mitsui T, Nakamura Y, Kira S, Nakagomi H, Sawada N, Hirayama Y, Shibata K, Shigetomi E, Shinozaki Y, Yoshiyama M, Andersson KE, Nakao A, Takeda M, Koizumi S: Clock Genes Regulate the Circadian Expression of Piezo1, TRPV4, Connexin26, and VNUT in an Ex Vivo Mouse Bladder Mucosa. PLoS One 12(1):e0168234, 2017
2017
Ihara T, Mitsui T, Nakamura Y, Kanda M, Tsuchiya S, Kira S, Nakagomi H, Sawada N, Kamiyama M, Shigetomi E, Shinozaki Y, Yoshiyama M, Nakao A, Takeda M, Koizumi S: The time-dependent variation of ATP release in mouse primary-cultured urothelial cells is regulated by the clock gene. Neurourol Urodyn 37(8)2535-2543, 2018
Ihara T, Mitsui T, Nakamura Y, Kanda M, Tsuchiya S, Kira S, Nakagomi H, Sawada N, Kamiyama M, Hirayama Y, Shigetomi E, Shinozaki Y, Yoshiyama M, Nakao A, Takeda M, Koizumi S: The oscillation of intracellular Ca2+ influx associated with the circadian expression of Piezo1 and TRPV4 in the bladder urothelium. Scientific Reports 8(1)5699, 2018
Ihara T, Mitsui T, Nakamura Y, Kanda M, Tsuchiya S, Kira S, Nakagomi H, Sawada N, Hirayama Y, Shibata K, Shigetomi E, Shinozaki Y, Yoshiyama M, Nakao A, Takeda M, Koizumi S: The Circadian expression of Piezo1, TRPV4, Connexin26, and VNUT, associated with the expression levels of the clock genes in mouse primary cultured urothelial cells. Neurourol Urodyn 37(3)942-951, 2018
Matsuzawa T, Nakamura Y, Ogawa Y, Ishimaru K, Goshima F, Shimada S, Nakao A, Kawamura T: Differential Day–Night Outcome to HSV-2 Cutaneous Infection. Journal of Investigative Dermatology 138(1)233-236, 2018
2018
Ishimaru K, Nakajima S, Yu G, Nakamura Y, Nakao A: The Putatively Specific
Synthetic REV-ERB Agonist SR9009 Inhibits IgE- and IL-33-Mediated Mast
Cell Activation Independently of the Circadian Clock. Int J Mol Sci 20(24)6320,
2019
Isobe J, Maeda S, Obata Y, Iizuka K, Nakamura Y, Fujimura Y, Kimizuka T, Hattori K, Yun-Gi Kim, Morita T, Kimura I, Offermanns S, Adachi T, Nakao A, Kiyono H, Takahashi D, Hase K: Commensal-bacteria-derived butyrate promotes the T cell-independent IgA response in the colon. Int Immunol 32(4):243-258, 2020
Nakajima S,Ishimaru K, Kobayashi A, Guannan Yu, Nakamura Y, Oh-oka K, Suzuki-Inoue K, Kono K, Nakao A: Resveratrol inhibits IL-33–mediated mast cell activation by targeting the MK2/3–PI3K/Akt axis. Sci Rep 9(1):18423, 2019
Nakamura Y, Sasaki T, Mochizuki C, Ishimaru K, Koizumi S, Shinmori H, Suzuki-Inoue K, Nakao A: Snake venom rhodocytin induces plasma extravasation via toxin-mediated interactions between platelets and mast cells. Sci Rep 9(1):15958, 2019
Fukano C, Ohashi-Doi K, Lund K, Nakao A, Masuyama K, Matsuoka T: Establishment of enzyme-linked immunosorbent facilitated antigen binding as a biomarker assay for Japanese cedar pollen allergy immunotherapy. J Pharmacol Sci 140(3):223-227, 2019
Ihara T, Nakamura Y, Mitsui T, Tsuchiya S, Kanda M, Kira S, Nakagomi H, Sawada N, Kamiyama M, Shigetomi E, Shinozaki Y, Yoshiyama M, Nakao A, Koizumi S, Takeda M: Intermittent restraint stress induces circadian misalignment in the mouse bladder, leading to nocturia. Sci Rep 9(1):10069, 2019
Takahashi T, Fukudome H, Hiroshi M. Ueno, Watanabe-Matsuhashi S, Nakano T, Kobayashi T, Ishimaru K, Nakao A: Effects of Probiotic Supplementation on TGF-β1, TGF-β2, and IgA Levels in the Milk of Japanese Women: An Open-Label Pilot Study. frontiers in Nutrition 6:128 eCllection 2019
2019
Moriguchi T, Harii N, Goto J, Harada D, Sugawara H, Takamino J, Ueno M,
Sakata H, Kondo K, Myose N, Nakao A, Takeda M, Haro H, Inoue O, Suzuki-Inoue
K, Kubokawa K, Ogihara S, Sasaki T, Kinouchi H, Kojin H, Ito M, Onishi
H, Shimizu T, Sasaki Y, Enomoto N, Ishihara H, Furuya S, Yamamoto T, Shimada
S: A first case of meningitis/encephalitis associated with SARS-Coronavirus-2.
Int J Infect Dis 94:55-58, 2020
Nakajima S, Manita S, Yu G, Ishimaru K, Kono K, Kitamura K,Nakao A: Activation of the reward system ameliorates passive cutaneous anaphylactic reaction in mice. Allergy 75(12):3275-3279, 2020
Nakao A: Circadian Regulation of the Biology of Allergic Disease: Clock Disruption Can Promote Allergy. [Review] Frontiers in Immunology 11:1237, 2020
2020
Nakao A, Nakamura Y: Time will tell about mast cells: Circadian control of mast cell activation. Allergology International 71(4):425-431, 2022
Nakao A: Welcome to "Circadian Immunology & Allergology": Why timing
matters in diagnosing and treating allergies. [Editorial] Allergology International 71(4):423-424, 2022
2022
1996
Iwamoto I, Kumano K, Kasai M, Kurasawa K, Nakao A:IL-12 prevents antigen-induced eosinophil recruitment into the mouse airways. Am J Resp Crit Care Med 154:1257-1260, 1996
2023
Nagasaka Y, Nakamura Y, Nguyen Quoc Vuong Tran, Kobayashi Y, Nakano N, Nakao A: Deficiency of BMAL1 promotes ROS generation and enhances IgE-dependent degranulation in mast cells. Biochem Biophys Res Commun 690:149295, 2023
Tran Nguyen Quoc Vuong, Le Minh Khang, Nakamura Y, Kondo T, Nakao A: A link between KIT expression, mast cell abundance and activity, and
Th2-high endotype in asthmatic airways Allergy 79(5):1338-1342 2023
Kobayashi Y, Suzuki K, Tateno M, Nakamura Y, Ishimaru K, Nagasaka Y, Sakurai
D, Ohashi-Doi K, Nakao A:Cha o 3, a cypress polle allergen, does not activate basophils in Japanese
cypress pollinosis J Allergy Clin Immun Global 3(1):100198, 2023
Thuy-An Nguyen, Minh-Khang Le, Phuc-Tan Nguyen, Nguyen Quoc Vuong Tran, Tetuo Kondo, Atsuhito Nakao: SLC22A3 that encodes organic cation transporter-3 is associated with prognosis and immunogenicity of human lung aquamous cell carcinoma. Transl Lung Cancer Res 2023;12(10):1972-1986
Phuc-Tan Nguyen, Nakamura Y , Nguyen Quoc Vuong Tran , Ishimaru K , Thuy-An Nguyen ,Kobayashi Y, Watanabe-Saito F, Okuda T, Nakano N , Nakao A: Ethyl Caffeate Can Inhibit Aryl Hydrocarbon Receptor (AhR) Signaling and AhR-Mediated Potentiation of Mast Cell Activation.Int J Mol Sci24(12), 9997, 2023
Nguyen Quoc Vuong Tran, Minh-Khang Le, Thuy-An Nguyen, Kondo T, Nakao A: Association of Circadian Clock Gene Expression with Pediatric/Adolescent Asthma and Its Comorbidities. Int J Mol Sci 24(8):7477, 2023
Nakao A:Inhibitory Smads: mechanisms of action and roles in human diseases. p.379-395,
In Smad Signal Transduction:Smads in proliferation, differentiation and
disease, Proteins and cell regulation vol5 ed. Peter ten Dijke, Carl-Henrik
Heldin, eds.Springer, Netherlands, 2006
Inagaki Y, Nemoto T, Nakao A: Transcriptional activation of type I collagen gene during hepatic fibrogenesis.
In: Extracellular Matrix and the Liver. Okazaki I, Nimomiya Y, Friedman
SL, Tanikawa K (eds), p233-248, Academic Press, London, UK, 2003