研究業績_~2005

~2005

2005

Kitajima S, Liu E, Morimoto M, Koike T, Yu Y, Watanabe T, Imagawa S, Fan J.
Transgenic rabbits with increased VEGF expression develope hemangiomas in the liver: a new model for Kasabach-Merritt syndrome.
Lab Invest. 2005 Dec;85(12):1517-27.
Sun H, Koike T, Ichikawa T, Hatakeyama K, Shiomi M, Zhang B, Kitajima S, Morimoto M, Asada Y, Watanabe T, Chen YE, Fan J.
C-reactive protein in atherosclerotic lesions: its origin and pathophysiological significance.
Am J Pathol. 2005 Oct;167(4):1139-48.
本論文が、Am J Pathol誌の、「最も読まれた論文50編」に選ばれました!!
Watanabe N, Nakagawa H, Kitajima S, Liu E, Morimoto M, Watanabe T, Fan J.
Establishment of a SPF colony of human apo(a) transgenic rabbits by frozen-thawed embryo transfer.
Exp Anim. 2005 Jul;54(4):353-7.
Ichikawa T, Liang J, Kitajima S, Koike T, Wang X, Sun H, Morimoto M, Shikama H, Watanabe T, Yamada N, Fan J.
Macrophage-derived lipoprotein lipase increases aortic atherosclerosis in cholesterol-fed transgenic rabbits.
Atherosclerosis. 2005 Mar;179(1):87-95.Epub 2004 Dec 25.
Koike T, Liang J, Wang X, Ichikawa T, Shiomi M, Sun H, Watanabe T, Liu G, Fan J.
Enhanced aortic atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits expressing lipoprotein lipase.
Cardiovasc Res. 2005 Feb 1;65(2):524-34.
Liu E, Kitajima S, Higaki Y, Morimoto M, Sun H, Watanabe T, Yamada N, Fan J.
High lipoprotein lipase activity increases insulin sensitivity in transgenic rabbits.
Metabolism. 2005 Jan;54(1):132-8.

2004

Xi S, Yin W, Wang Z, Kusunoki M, Lian X, Koike T, Fan J, Zhang Q.
A minipig model of high-fat/high-sucrose diet-induced diabetes and atherosclerosis.
Int J Exp Pathol. 2004 Oct;85(4):223-31.
Liu M, Sun H, Wang X, Koike T, Mishima H, Ikeda K, Watanabe T, Ochiai N, Fan J.
Association of increased expression of macrophage elastase (matrix metalloproteinase 12) with rheumatoid arthritis.
Arthritis Rheum. 2004 Oct;50(10):3112-7.
Wang X, Liang J, Koike T, Sun H, Ichikawa T, Kitajima S, Morimoto M, Shikama H, Watanabe T, Sasaguri Y, Fan J.
Overexpression of human matrix metalloproteinase-12 enhances the development of inflammatory arthritis in transgenic rabbits.
Am J Pathol. 2004 Oct;165(4):1375-83.
Xiong S, Wang YF, Zhang MY, Liu XJ, Zhang CH, Liu SS, Qian CW, Li JX, Lu JH, Wan ZY, Zheng HY, Yan XG, Meng MJ, Fan J.
Immunogenicity of SARS inactivated vaccine in BALB/c mice.
Immunol Lett. 2004 Sep;95(2):139-43.
Shiomi M, Ito T, Yamada S, Kawashima S, Fan J.
Correlation of vulnerable coronary plaques to sudden cardiac events.Lessons from a myocardial infarction-prone animal model (the WHHLMI rabbit).
J Atheroscler Thromb. 2004;11(4):184-9. Reviews.
Kitajima S, Morimoto M, Liu E, Koike T, Higaki Y, Taura Y, Mamba K, Itamoto K, Watanabe T, Tsutsumi K, Yamada N, Fan J.
Overexpression of lipoprotein lipase improves insulin resistance induced by a high-fat diet in transgenic rabbits.
Diabetologia. 2004 Jul;47(7):1202-9.Epub 2004 Jun 25.
Zhang AH, Gao S, Fan J, Huang W, Zhao TQ, Liu G.
Increased plasma HDL cholesterol levels and biliary cholesterol excretion in hamster by LCAT overexpression.
FEBS Lett. 2004 Jul 16;570(1-3):25-9.
Fan J, Wang X, Wu L, Matsumoto SI, Liang J, Koike T, Ichikawa T, Sun H, Shikama H, Sasaguri Y, Watanabe T.
Macrophage-specific overexpression of human matrix metalloproteinase-12 in transgenic rabbits.
Transgenic Res. 2004 Jun;13(3):261-9.
Ichikawa T, Kitajima S, Liang J, Koike T, Wang X, Sun H, Okazaki M, Morimoto M, Shikama H, Watanabe T, Yamada N, Fan J.
Overexpression of lipoprotein lipase in transgenic rabbits leads to increased small dense LDL in plasma and promotes atherosclerosis.
Lab Invest. 2004 Jun;84(6):715-26.
Yin W, Liao D, Kusunoki M, Xi S, Tsutsumi K, Wang Z, Lian X, Koike T, Fan J, Yang Y, Tang C.
NO-1886 decreases ectopic lipid deposition and protects pancreatic beta cells in diet-induced diabetic swine.
J Endocrinol. 2004 Mar;180(3):399-408.
Yin W, Liao D, Wang Z, Xi S, Tsutsumi K, Koike T, Fan J, Yi G, Zhang Q, Yuan Z, Tang K.
NO-1886 inhibits size of adipocytes, suppresses plasma levels of tumor necrosis factor-alpha and free fatty acids, improves glucose metabolism in high-fat/high-sucrose-fed miniature pigs.
Pharmacol Res. 2004 Mar;49(3):199-206.
Koike T, Liang J, Wang X, Ichikawa T, Shiomi M, Liu G, Sun H, Kitajima S, Morimoto M, Watanabe T, Yamada N, Fan J.
Overexpression of lipoprotein lipase in transgenic Watanabe heritable hyperlipidemic rabbits improves hyperlipidemia and obesity.
J Biol Chem. 2004 Feb 27;279(9):7521-9. Epub 2003 Dec 3.

2003

Fan J, Watanabe T.
Transgenic rabbits as therapeutic protein bioreactors and human disease models.
Pharmacol Ther. 2003 Sep;99(3):261-82. Review.
Shiomi M, Fan J, Kawashima S.
Relation of vulnerable plaque to development of myocardial infarction/ acute coronary syndromes - Lessons from an animal model of spontaneous myocardial infarction.
International Atherosclerosis Society Commentary 2003, Aug http://www.athero.org
Shiomi M, Ito T, Yamada S, Kawashima S, Fan J.
Development of an animal model for spontaneous myocardial infarction (WHHLMI rabbit).
Arterioscler Thromb Vasc Biol. 2003 Jul 1;23(7):1239-44.Epub 2003 May 8.
Fan J, Watanabe T.
Inflammatory reactions in the pathogenesis of atherosclerosis.
J Atheroscler Thromb. 2003;10(2):63-71. Review.
Wu L, Tanimoto A, Murata Y, Sasaguri T, Fan J, Sasaguri Y, Watanabe T.
Matrix metalloproteinase-12 gene expression in human vascular smooth muscle cells.
Genes Cells. 2003 Mar;8(3):225-34.
Kitajima S, Morimoto M, Watanabe T, Fan J.
Transgenic rabbits: Production and applications for human disease models.
Recent Res Dev Biophy Biochem. 2003, 3:179-194.

2002

Koike T, Wang X, Unoki H, Liang J, Ichikawa T, Kitajima S, Watanabe T, Fan J.
Increased expression of lipoprotein lipase in transgenic rabbits does not lead to abnormalities in skeletal and heart muscles.
Muscle Nerve. 2002 Dec;26(6):823-7.
Sun H, Unoki H, Wang X, Liang J, Ichikawa T, Arai Y, Shiomi M, Marcovina SM, Watanabe T, Fan J.
Lipoprotein(a) enhances advanced atherosclerosis and vascular calcification in WHHL transgenic rabbits expressing human apolipoprotein(a).
J Biol Chem. 2002 Dec 6;277(49):47486-92.Epub 2002 Aug 23.
Shimoyamada H, Fan J, Watanabe T, Nagata M.
Accelerated atherosclerosis with apolipoprotein(a) and oxidized low-density lipoprotein deposition in acute rejection of transplanted kidney: analogous to atherosclerosis.
Clin Transplant. 2002;16 Suppl 8:35-9.
Sun H, Usui S, Siomi M, Watanabe T, Fan J.
A rapid PCR method of genotyping LDL receptor mutations in WHHL rabbits.
J Atheroscler Thromb. 2002;9(3):145-8.
Ichikawa T, Unoki H, Sun H, shimoyamada H, Marcovina S, Shikama H, Watanabe T, Fan J.
Lipoprotein(a) promotes smooth muscle cell proliferation and dedifferentiation in atherosclerotic lesions of human apo(a) transgenic rabbits.
Am J Pathol. 2002 Jan;160(1):227-36.

~2001

Fan J, Sun H, Unoki H, Shiomi M, Watanabe T.
Enhanced atherosclerosis in Lp(a) WHHL transgenic rabbits.
Ann N Y Acad Sci. 2001 Dec;947:362-5.
Fan J, Unoki H, Kojima N, Sun H, Shimoyamada H, Deng H, Okazaki M, Shikama H, Yamada N, Watanabe T.
Overexpression of lipoprotein lipase in transgenic rabbits inhibits diet-induced hypercholesterolemia and atherosclerosis.
J Biol Chem. 2001 Oct 26;276(43):40071-9.Epub 2001 Jul 26.
Fan J, Shimoyamada H, Sun H, Marcovina S, Honda K, Watanabe T.
Transgenic rabbits expressing human apolipoprotein(a) develop more extensive atherosclerotic lesions in response to a cholesterol-rich diet.
Arterioscler Thromb Vasc Biol. 2001 Jan;21(1):88-94.
Fan J, Challah M, Shimoyamada H, Shiomi M, Marcovina S, Watanabe T.
Defects of the LDL receptor in WHHL transgenic rabbits lead to a marked accumulation of plasma lipoprotein[a].
J Lipid Res. 2000 Jun;41(6):1004-12.
Fan J, Araki M, Wu L, Challah M, Shimoyamada H, Lawn RM, Kakuta H, Shikama H, Watanabe T.
Assembly of lipoprotein (a) in transgenic rabbits expressing human apolipoprotein (a).
Biochem Biophys Res Commun. 1999 Feb 24;255(3):639-44.
Fan J, Ji ZS, Huang Y, de Silva H, Sanan D, Mahley RW, Innerarity TL, Taylor JM.
Increased expression of apolipoprotein E in transgenic rabbits results in reduced levels of very low density lipoproteins and an accumulation of low density lipoproteins in plasma.
J Clin Invest. 1998 May 15;101(10):2151-64.