研究業績_～2005 | 山梨大学分子病理学講座

～2005

2005

Kitajima S, Liu E, Morimoto M, Koike T, Yu Y, Watanabe T, Imagawa S, Fan J.: Transgenic rabbits with increased VEGF expression develope hemangiomas in the liver: a new model for Kasabach-Merritt syndrome.
Lab Invest. 2005 Dec;85(12):1517-27.
Sun H, Koike T, Ichikawa T, Hatakeyama K, Shiomi M, Zhang B, Kitajima S, Morimoto M, Asada Y, Watanabe T, Chen YE, Fan J.: C-reactive protein in atherosclerotic lesions: its origin and pathophysiological significance.
Am J Pathol. 2005 Oct;167(4):1139-48.
本論文が、Am J Pathol誌の、「最も読まれた論文50編」に選ばれました！！
Wu X, Wang J, Fan J, Chen M, Chen L, Huang W, Liu G.: Localized vessel expression of lipoprotein lipase in rabbits leads to rapid lipid deposition in the balloon-injured arterial wall.
Atherosclerosis. 2006 Jul;187(1):65-73. Epub 2005 Sep 26.
Watanabe N, Nakagawa H, Kitajima S, Liu E, Morimoto M, Watanabe T, Fan J.: Establishment of a SPF colony of human apo(a) transgenic rabbits by frozen-thawed embryo transfer.
Exp Anim. 2005 Jul;54(4):353-7.
Ichikawa T, Liang J, Kitajima S, Koike T, Wang X, Sun H, Morimoto M, Shikama H, Watanabe T, Yamada N, Fan J.: Macrophage-derived lipoprotein lipase increases aortic atherosclerosis in cholesterol-fed transgenic rabbits.
Atherosclerosis. 2005 Mar;179(1):87-95.Epub 2004 Dec 25.
Koike T, Liang J, Wang X, Ichikawa T, Shiomi M, Sun H, Watanabe T, Liu G, Fan J.: Enhanced aortic atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits expressing lipoprotein lipase.
Cardiovasc Res. 2005 Feb 1;65(2):524-34.
Liu E, Kitajima S, Higaki Y, Morimoto M, Sun H, Watanabe T, Yamada N, Fan J.: High lipoprotein lipase activity increases insulin sensitivity in transgenic rabbits.
Metabolism. 2005 Jan;54(1):132-8.

2004

Xi S, Yin W, Wang Z, Kusunoki M, Lian X, Koike T, Fan J, Zhang Q.: A minipig model of high-fat/high-sucrose diet-induced diabetes and atherosclerosis.
Int J Exp Pathol. 2004 Oct;85(4):223-31.
Liu M, Sun H, Wang X, Koike T, Mishima H, Ikeda K, Watanabe T, Ochiai N, Fan J.: Association of increased expression of macrophage elastase (matrix metalloproteinase 12) with rheumatoid arthritis.
Arthritis Rheum. 2004 Oct;50(10):3112-7.
Wang X, Liang J, Koike T, Sun H, Ichikawa T, Kitajima S, Morimoto M, Shikama H, Watanabe T, Sasaguri Y, Fan J.: Overexpression of human matrix metalloproteinase-12 enhances the development of inflammatory arthritis in transgenic rabbits.
Am J Pathol. 2004 Oct;165(4):1375-83.
Xiong S, Wang YF, Zhang MY, Liu XJ, Zhang CH, Liu SS, Qian CW, Li JX, Lu JH, Wan ZY, Zheng HY, Yan XG, Meng MJ, Fan J.: Immunogenicity of SARS inactivated vaccine in BALB/c mice.
Immunol Lett. 2004 Sep;95(2):139-43.
Shiomi M, Ito T, Yamada S, Kawashima S, Fan J.: Correlation of vulnerable coronary plaques to sudden cardiac events.Lessons from a myocardial infarction-prone animal model (the WHHLMI rabbit).
J Atheroscler Thromb. 2004;11(4):184-9. Reviews.
Zhang AH, Gao S, Fan J, Huang W, Zhao TQ, Liu G.: Increased plasma HDL cholesterol levels and biliary cholesterol excretion in hamster by LCAT overexpression.
FEBS Lett. 2004 Jul 16;570(1-3):25-9.
Kitajima S, Morimoto M, Liu E, Koike T, Higaki Y, Taura Y, Mamba K, Itamoto K, Watanabe T, Tsutsumi K, Yamada N, Fan J.: Overexpression of lipoprotein lipase improves insulin resistance induced by a high-fat diet in transgenic rabbits.
Diabetologia. 2004 Jul;47(7):1202-9.Epub 2004 Jun 25.
Fan J, Wang X, Wu L, Matsumoto SI, Liang J, Koike T, Ichikawa T, Sun H, Shikama H, Sasaguri Y, Watanabe T.: Macrophage-specific overexpression of human matrix metalloproteinase-12 in transgenic rabbits.
Transgenic Res. 2004 Jun;13(3):261-9.
Ichikawa T, Kitajima S, Liang J, Koike T, Wang X, Sun H, Okazaki M, Morimoto M, Shikama H, Watanabe T, Yamada N, Fan J.: Overexpression of lipoprotein lipase in transgenic rabbits leads to increased small dense LDL in plasma and promotes atherosclerosis.
Lab Invest. 2004 Jun;84(6):715-26.
Yin W, Liao D, Kusunoki M, Xi S, Tsutsumi K, Wang Z, Lian X, Koike T, Fan J, Yang Y, Tang C.: NO-1886 decreases ectopic lipid deposition and protects pancreatic beta cells in diet-induced diabetic swine.
J Endocrinol. 2004 Mar;180(3):399-408.
Yin W, Liao D, Wang Z, Xi S, Tsutsumi K, Koike T, Fan J, Yi G, Zhang Q, Yuan Z, Tang K.: NO-1886 inhibits size of adipocytes, suppresses plasma levels of tumor necrosis factor-alpha and free fatty acids, improves glucose metabolism in high-fat/high-sucrose-fed miniature pigs.
Pharmacol Res. 2004 Mar;49(3):199-206.

2003

Koike T, Liang J, Wang X, Ichikawa T, Shiomi M, Liu G, Sun H, Kitajima S, Morimoto M, Watanabe T, Yamada N, Fan J.: Overexpression of lipoprotein lipase in transgenic Watanabe heritable hyperlipidemic rabbits improves hyperlipidemia and obesity.
J Biol Chem. 2004 Feb 27;279(9):7521-9. Epub 2003 Dec 3.
Fan J, Watanabe T.: Transgenic rabbits as therapeutic protein bioreactors and human disease models.
Pharmacol Ther. 2003 Sep;99(3):261-82. Review.
Shiomi M, Fan J, Kawashima S.: Relation of vulnerable plaque to development of myocardial infarction/ acute coronary syndromes - Lessons from an animal model of spontaneous myocardial infarction.
International Atherosclerosis Society Commentary 2003, Aug http://www.athero.org
Shiomi M, Ito T, Yamada S, Kawashima S, Fan J.: Development of an animal model for spontaneous myocardial infarction (WHHLMI rabbit).
Arterioscler Thromb Vasc Biol. 2003 Jul 1;23(7):1239-44.Epub 2003 May 8.
Fan J, Watanabe T.: Inflammatory reactions in the pathogenesis of atherosclerosis.
J Atheroscler Thromb. 2003;10(2):63-71. Review.
Wu L, Tanimoto A, Murata Y, Sasaguri T, Fan J, Sasaguri Y, Watanabe T.: Matrix metalloproteinase-12 gene expression in human vascular smooth muscle cells.
Genes Cells. 2003 Mar;8(3):225-34.
Kitajima S, Morimoto M, Watanabe T, Fan J.: Transgenic rabbits: Production and applications for human disease models.
Recent Res Dev Biophy Biochem. 2003, 3:179-194.

2002

Koike T, Wang X, Unoki H, Liang J, Ichikawa T, Kitajima S, Watanabe T, Fan J.: Increased expression of lipoprotein lipase in transgenic rabbits does not lead to abnormalities in skeletal and heart muscles.
Muscle Nerve. 2002 Dec;26(6):823-7.
Sun H, Unoki H, Wang X, Liang J, Ichikawa T, Arai Y, Shiomi M, Marcovina SM, Watanabe T, Fan J.: Lipoprotein(a) enhances advanced atherosclerosis and vascular calcification in WHHL transgenic rabbits expressing human apolipoprotein(a).
J Biol Chem. 2002 Dec 6;277(49):47486-92.Epub 2002 Aug 23.
Shimoyamada H, Fan J, Watanabe T, Nagata M.: Accelerated atherosclerosis with apolipoprotein(a) and oxidized low-density lipoprotein deposition in acute rejection of transplanted kidney: analogous to atherosclerosis.
Clin Transplant. 2002;16 Suppl 8:35-9.
Sun H, Usui S, Siomi M, Watanabe T, Fan J.: A rapid PCR method of genotyping LDL receptor mutations in WHHL rabbits.
J Atheroscler Thromb. 2002;9(3):145-8.
Ichikawa T, Unoki H, Sun H, shimoyamada H, Marcovina S, Shikama H, Watanabe T, Fan J.: Lipoprotein(a) promotes smooth muscle cell proliferation and dedifferentiation in atherosclerotic lesions of human apo(a) transgenic rabbits.
Am J Pathol. 2002 Jan;160(1):227-36.

～2001

Fan J, Sun H, Unoki H, Shiomi M, Watanabe T.: Enhanced atherosclerosis in Lp(a) WHHL transgenic rabbits.
Ann N Y Acad Sci. 2001 Dec;947:362-5.
Fan J, Unoki H, Kojima N, Sun H, Shimoyamada H, Deng H, Okazaki M, Shikama H, Yamada N, Watanabe T.: Overexpression of lipoprotein lipase in transgenic rabbits inhibits diet-induced hypercholesterolemia and atherosclerosis.
J Biol Chem. 2001 Oct 26;276(43):40071-9.Epub 2001 Jul 26.
Fan J, Challah M, Shimoyamada H, Shiomi M, Marcovina S, Watanabe T.: Defects of the LDL receptor in WHHL transgenic rabbits lead to a marked accumulation of plasma lipoprotein[a].
J Lipid Res. 2000 Jun;41(6):1004-12.
Fan J, Ji ZS, Huang Y, de Silva H, Sanan D, Mahley RW, Innerarity TL, Taylor JM.: Increased expression of apolipoprotein E in transgenic rabbits results in reduced levels of very low density lipoproteins and an accumulation of low density lipoproteins in plasma.
J Clin Invest. 1998 May 15;101(10):2151-64.
Fan J, Araki M, Wu L, Challah M, Shimoyamada H, Lawn RM, Kakuta H, Shikama H, Watanabe T.: Assembly of lipoprotein (a) in transgenic rabbits expressing human apolipoprotein (a).
Biochem Biophys Res Commun. 1999 Feb 24;255(3):639-44.
Fan J, Shimoyamada H, Sun H, Marcovina S, Honda K, Watanabe T.: Transgenic rabbits expressing human apolipoprotein(a) develop more extensive atherosclerotic lesions in response to a cholesterol-rich diet.
Arterioscler Thromb Vasc Biol. 2001 Jan;21(1):88-94.