English

Neuropharmacology

We have worked on brain functions from the point of view of glial functions. Glial cells are divided into astrocytes, microglia and oligodendrocytes, whose number is much higher than neurons. Glial cells were thought to be merely supportive cells, but they have been found to be rather active cells in terms of Ca2+ excitation etc. They express several receptors of neurotransmitters, and receive these transmitters, and release the chemical transmitters so called “gliotransmitters”. Thus, we believe that neuron-to-glia communication is a fundamental base of information processing. In addition to physiological roles in the, glial cells are thought to be involved in pathogenesis of several brain diseases, because they change their phenotypes dramatically in response to changes in brain environments. We think that dysfunction of glial cells should highly affect brain functions, leading to several brain diseases. Our goal is to clarify mechanisms underlying neuron-to-glia communication in physiological and pathophysiological brains, and understand brain functions comprehensively.

Anatomy and Structural Biology

Staff

Name Title・Positions Main Research Focus
Schuichi KOIZUMI Professor Glia-neuron interaction
Youichi SHINOZAKI Senior Assistant Professor Glia-neuron communication in the retina
Eiji SHIGETOMI Assistant Professor Astrocyte-neuron communication in the hippocampus
Bijay PARAJULI Project Assistant Professor Microglia-neuron interaction

Website

https://www.med.yamanashi.ac.jp/clinical_basic/pharmaco/0-English/E-home.html

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