NEURO2026 参加報告
安達 京聡さん
私はこの度、神戸国際会議場/神戸国際展示場にて開催されました、NEURO2026(第49回日本神経科学大会・第69回日本神経化学会大会・第36回日本神経回路学会大会 合同大会)に参加し、「勝利経験が初対面で形成される社会的階層に及ぼす影響について」というテーマでポスター発表を行いました。
ライフサイエンスコースに所属して1年半が経ちますが、学会参加及び発表は初めての経験であり、私自身にとって非常に刺激的で良い経験となりました。発表中に多くの先生方から様々なご意見、ご指導をいただき、大学で研究しているだけでは決して得られないような、素晴らしい学びの機会となりました。他大学の先生方や同年代の研究者と私の差も痛感し、今後の研究のモチベーションをさらに高めることができました。
今回の学会参加・発表に際し、日頃よりご指導ならびにご支援をいただいた篠原教授、吉崎先生をはじめ、解剖学講座システム生物学教室の皆様、およびライフサイエンスコース事務局の皆様に、この場をお借りして深く御礼申し上げます。
以下が抄録になります。
Social hierarchy is a structured ranking of individuals based on relative status, formed during initial encounters and shaped by subsequent social interactions. In animal studies, many researchers have focused on how social rank is shaped through group housing and investigated its underlying neural mechanisms. However, the effects of first contact on subsequent ranking formation remain relatively understudied. Here, we investigated the possible effects of initial encounters on the formation of social rank. C57BL/6J and stranger ICR mice (8-9-week-old, male) were subjected to a tube test. Then, the subordinate mice underwent a “WIN experience” using a forced-win tube test with a shutter placed behind the subordinate mice to prevent retreat. As a result, the subordinate mice repeatedly experienced pushing the dominant mice out of the tube (4 trials per day for 15 days). Finally, to assess the effects of the “WIN experience” on subsequent social rank, the tube test was conducted again with the same pairs as in the initial tube test and with novel pairs. Our preliminary data indicated that almost all ICR mice won C57BL/6J mice in the initial tube test. Unexpectedly, the subordinate C57BL/6J mice that underwent a “WIN experience” did not exhibit improved competitive outcomes over ICR mice, and consistently lost in subsequent tube tests. Since previous studies reported that “WIN experience” in subordinate mice can modulate subsequent social rank when assessed among C57BL/6J mice following group housing, our results suggest that the influence of “WIN experience” on social rank may be context-dependent, particularly with respect to social rank formed during first contact. In the future, we are going to increase the sample size and elucidate the underlying neural mechanisms.
